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[ CAS No. 885677-92-9 ] {[proInfo.proName]}

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Chemical Structure| 885677-92-9
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Product Details of [ 885677-92-9 ]

CAS No. :885677-92-9 MDL No. :MFCD09054931
Formula : C10H20N2 Boiling Point : -
Linear Structure Formula :- InChI Key :FLEFKPPJPOWCSZ-NXEZZACHSA-N
M.W : 168.28 Pubchem ID :14350175
Synonyms :

Safety of [ 885677-92-9 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P280-P305+P351+P338-P304+P340 UN#:
Hazard Statements:H302 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 885677-92-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 885677-92-9 ]

[ 885677-92-9 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 885677-92-9 ]
  • [ 1223105-85-8 ]
  • [ 1211565-10-4 ]
YieldReaction ConditionsOperation in experiment
80% In methanol for 16h;
  • 2
  • [ 885677-92-9 ]
  • [ 137848-28-3 ]
  • [ 5222-73-1 ]
  • 3-((R)-2'-hydroxy-1,1'-binaphthyl-2-ylamino)-4-((1R,2R)-2-(pyrrolidin-1-yl)cyclohexylamino)cyclobut-3-ene-1,2-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
50% General procedure: To a mixture of 3,4-dimethoxy-3-cyclobutene-1 ,2-dione (Ia) (0.2 mmol) in MeOH (0.25- 1 mL) the amine 2a-m was firstly added at room temperature. After the correspondingreaction time (ti) (see Table I), the amine 4a-n (0.2 mmol) was then added with MeOH (1.75-1 mL). After the corresponding reaction time (t2) (see Table I and Table Ibis), the product was purified by filtration or by column chromatography. Yields are reported in Table I and Table Ibis and pure compounds were obtained as stable solids.
  • 3
  • [ 885677-92-9 ]
  • [ CAS Unavailable ]
  • [ 1314743-49-1 ]
YieldReaction ConditionsOperation in experiment
Stage #1: (1R,2R)-2-(pyrrolidin-1-yl)cyclohexan-1-amine With hydrogenchloride In water at 150℃; for 1h; Microwave irradiation; Stage #2: isothiocyanato-3,5-bis(trifluoromethyl)benzene With triethylamine In tetrahydrofuran for 2h; 5.3 A mixture of 128 (4.58 mmol, 1 eq), R-X (11.9 mmol, 2.5 eq), K2C03 (11.9Mmol, 2.5 eq) and water (18 ml) were added to a microwave vial. The reaction tube was placed in a microwave reactorInto the system and operated at 120 ° C for 35 min. After completion of the reaction (by HPLC and LC-MSMonitoring), the organic portion was extracted in EtOAc (3 * 20 ml) and the solvent was removed under reduced pressureA pale yellow solid was obtained which was used directly in step 2. Add in a microwave vial (10-20 ml)Crude and HC1 6 N (10 ml). The reaction tubes were placed in a microwave synthesis system at 150 & lt; RTI ID = 0.0 & gt;° C for 1 h. After completion of the reaction (monitored by HPLC and LC-MS), the organic fraction was extractedTake DCM (3 * 10 ml) (HPLC showed benzoic acid). The organic phase was washed with HC1 2 N (3 *10 ml) and the aqueous phase (3 * 15 ml) was concentrated under reduced pressure and washed with ΜΟΗ to obtain a shallowYellow oil, which is used directly in step 3. THF was added to the crude from step 2(30 ml) and Et3N (1.5 ml) to give a white suspension and stir for 30 min. Add drop3,5-bis-trifluoromethyl-isothiocyanate (4.58 mmol, 1 eq) added to THF (15 ml) andStir for 2 h. The reaction was monitored by HPLC and LC-MS. The reaction mixture was filtered to remove threeEthyl ammonium salt; the organic phase was washed with NaOH 1 N (30 ml) and concentrated under reduced pressure to give a shallowBrown oil. The crude was purified by flash chromatography on a Biotage device.
  • 4
  • [ 885677-92-9 ]
  • [ 1233032-09-1 ]
  • [ 1211565-10-4 ]
YieldReaction ConditionsOperation in experiment
In dichloromethane at 20℃; for 12h;
  • 5
  • [ 885677-92-9 ]
  • [ 23165-29-9 ]
  • [ 1314743-49-1 ]
YieldReaction ConditionsOperation in experiment
59% In dichloromethane at 20℃; Inert atmosphere;
  • 6
  • [ 885677-92-9 ]
  • [ 1073917-05-1 ]
  • [ 2929312-21-8 ]
YieldReaction ConditionsOperation in experiment
82 % In dichloromethane at 25℃;
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