[ CAS No. 886364-86-9 ]

Name: 886364-86-9|5-Bromo-4-methylpicolinonitrile|97%
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Product Details of [ 886364-86-9 ]

CAS No. :	886364-86-9	MDL No. :	MFCD07375090
Formula :	C₇H₅BrN₂	Boiling Point :	293.3°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	-
M.W :	197.03 g/mol	Pubchem ID :	53395468
Synonyms :

Safety of [ 886364-86-9 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 886364-86-9 ]

Upstream synthesis route of [ 886364-86-9 ]
Downstream synthetic route of [ 886364-86-9 ]

[ 886364-86-9 ] Synthesis Path-Upstream 1~5

1
[ 773837-37-9 ]
[ 3430-26-0 ]
[ 886364-86-9 ]

Yield	Reaction Conditions	Operation in experiment
58%	at 158℃; for 3 h; sealed vessel	2,5-Dibromo-4-methylpyridine(5.0 g, 19.9 mmol), copper cyanide (1.43 g, 15.9 mmol), sodium cyanide (0.801 g, 16.3 mmol) and dimethylformamide (30 mL) were combined in a sealed reaction vessel and heated at 158 ⁰C for 3 h. The reaction mixture was purified by silica gel column chromatography (0-80 percent ethyl acetate in hexanes). The resulting material was subjected to a second silica gel column (0-20 percent methanol in dichloromethane). Clean fractions were combined and concentrated to afford the title compound as a white solid (2.3O g, 11.6 mmol, 58 percent yield). MS (ESI) m/z 198.0 [M+l]⁺.
42.4%	for 20 h; Reflux	5-bromo-4-methyl-pyridine-2-carbonitrile: To a solution of 2,5-dibromo-4-methylpyridine (15 g, 59.8 mmol, Eq: 1.00) in DMF (100 ml) was added copper(I) cyanide (4.28 g, 47.8 mmol, Eq: 0.8) and sodium cyanide (2.34 g, 47.8 mmol, Eq: 0.8). The reaction mixture was refluxed for 20 hr at which point a precipitate formed. Upon cooling water was added and the mixture sonicated. The solids were filtered and washed with water. The resulting filtrate was extracted with EtOAc and the organic layers then combined, washed with water and brine, and concentrated under reduced pressure. The crude material was then purified by column chromatography (0-10percent EtOAc/Hex gradient) to give 5-bromo-4-methyl-pyridine-2-carbonitrile (5 g, 42.4percent yield) as a white solid.

Reference： [1] Patent: WO2010/62571, 2010, A1, . Location in patent: Page/Page column 96
[2] Patent: US2013/90333, 2013, A1, . Location in patent: Paragraph 0184

2
[ 773837-37-9 ]
[ 3430-26-0 ]
[ 886364-86-9 ]

Yield	Reaction Conditions	Operation in experiment
42.4%	With copper(l) cyanide In N,N-dimethyl-formamide for 20 h; Reflux	5-bromo-4-methyl-pyridine-2-carbonitrile:To a solution of 2,5-dibromo-4-methylpyridine (15 g, 59.8 mmol, Eq: 1.00) in DMF (100 ml) was added copper(1) cyanide (4.28 g, 47.8 mmol, Eq: 0.8) and sodium cyanide (2.34 g, 47.8 mmol, Eq: 0.8). The reaction mixture was refluxed for 20 hr at which point a precipitate formed. Upon cooling water was added and the mixture sonicated. The solids were filtered and washed with water. The resulting filtrate was extracted with EtOAc and the organic layers then combined, washed with water and brine, and concentrated under reduced pressure. The crude material was then purified by column chromatography (0-10percent EtOAc/Hex gradient) to give 5-bromo-4-methyl-pyridine-2-carbonitrile (5 g, 42.4percent yield) as a white solid.

Reference： [1] Patent: US2013/90334, 2013, A1, . Location in patent: Paragraph 0153

3
[ 1070893-06-9 ]
[ 886364-86-9 ]

Reference： [1] Patent: WO2008/124610, 2008, A1, . Location in patent: Page/Page column 47
[2] Patent: WO2008/124614, 2008, A1, . Location in patent: Page/Page column 39

4
[ 98198-48-2 ]
[ 886364-86-9 ]

Reference： [1] Patent: WO2008/124610, 2008, A1,
[2] Patent: WO2008/124614, 2008, A1,

5
[ 3430-26-0 ]
[ 886364-86-9 ]

Reference： [1] Patent: WO2008/124610, 2008, A1,
[2] Patent: WO2008/124614, 2008, A1,

[ 886364-86-9 ] Synthesis Path-Downstream 1~26

1
[ 886364-86-9 ]
5-chloro-2-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-4-(4,4,5,5-tetramethyl[1,3]dioxolan-2-yl)phenol [ No CAS ]
[ 1070973-08-8 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 100℃; for 16h;	5-Chloro-2-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-4-(4,4,5,5- tetramethyl-[1 ,3]dioxolan-2-yl)-phenol (153.0 mg, 0.33 mmol), 5-bromo-4-methyl- pyridine-2-carbonitrile (60 mg, 0.30 mmol), Pd(Ph3P)4 (38 mg, 0.03 mmol) and K2CO3 ( 138 mg, 1.0 mmol) in a mixture of dioxane (4 ml_) and water (0.4 mL) was degassed with N2 for 5 min. The reaction vessel was sealed and then heated at 100 0C for 16 hrs. The mixture was then partitioned between ethyl acetate (20 mL) and water (10 mL). The organic layer was washed with brine (2 x 10 mL) and dried over MgSO4. After filtration and concentration, the material was purified by TLC plates eluting with ethyl acetate in hexanes (1/3) to give 5-[2-chloro-4-hydroxy-5-(2,3,4,5-tetrahydro- benzo[b]azepine-1-sulfonyl)-phenyl]-4-methyl-pyridine-2-carbonitrile 8-1 as a white solid (100 mg). MS: 453.9 (M+H)+; tR = 8.37 min (method 2).

Reference： [1]Patent: WO2008/124614,2008,A1 .Location in patent: Page/Page column 60-61

2
[ 1070893-06-9 ]
[ 886364-86-9 ]

Yield	Reaction Conditions	Operation in experiment
		This material was dissolved in toluene (10 mL). POCI3 (10 mL) was added and the solution refluxed for 5 h. After cooling to room temperature the solvents were removed in vacuo, the reaction was basified by addition of 2 M NaOH (aq) and extracted with ether. The organic extract was washed with brine, dried over MgSO4 and concentrated. Chromatography on silica gel eluting with 20% EtOAc/Hexane gave 5-bromo-2-cyano-4-methylpyridine 1-3 as an off-white crystalline solid (920 mg, 4.7 mmol, 64% over 2 steps). 1H NMR (300 MHz, CDCI3) 8.73 (1 H, s), 7.56 (1H, s), 2.46 (3H, s). MS [MH-H]+: 196.8.0; tR=2.04 min. (method 1).
		(5-Bromo-4-methylpyridin-2-yl)-N-t-butyl carboxylic amide was dissolved in toluene (10 mL). POCI3 (10 mL) was added and the solution refluxed for 5 h. After cooling to rt the solvents were removed in vacuo, the reaction was basified by addition of 2 M NaOH (aq) and extracted with ether. The organic extract was washed with brine, dried over MgSO4 and concentrated. Chromatography on silica gel eluting with 20% EtOAc/Hexane gave 5- bromo-2-cyano-4-methylpyridine 1-3 as an off-white crystalline solid (920 mg, 4.7 mmol, 64% over 2 steps). 1H NMR (300 MHz, CDCI3) 8.73 (1 H, s), 7.56 (1H, s), 2.46 (3H, s). MS [M+H]+: 196.8.0; tR=2.04 min. (method 1 ).

Reference： [1]Patent: WO2008/124610,2008,A1 .Location in patent: Page/Page column 47
[2]Patent: WO2008/124614,2008,A1 .Location in patent: Page/Page column 39

3
[ 886364-86-9 ]
[ 1070892-31-7 ]
[ 1070889-90-5 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; at 95℃; for 12h;	A mixture of 4-chloro-N-(2-hydroxy-phenyl)-N-methyl-3-(4,4,5,5- tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-benzamide (100 mg, 0.26 mmol), 5-bromo-4- methyl-pyridine-2-carbonitrile (61 mg, 0.31 mmol), Pd(PPh3)4 (15 mg, 0.013 mmol), K2CO3 (90 mg, 0.65 mmol) in dioxane (1.2 mL), was heated at 95 0C for 12 hrs. The mixture was diluted with EtOAc, washed with water and brine, dried (Na2SO4) and concentrated in vacuo. Silica gel column chromatography (eluent: ethyl acetate/hexane(1/4 up to 4/1 )) yielded 4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-(2- hydroxy-phenyl)-N-methyl-benzamide 8-1 (68 mg).

Reference： [1]Patent: WO2008/124610,2008,A1 .Location in patent: Page/Page column 69

4
[ 773837-37-9 ]
[ 3430-26-0 ]
copper(l) cyanide [ No CAS ]
[ 886364-86-9 ]

Yield	Reaction Conditions	Operation in experiment
58%	In N,N-dimethyl-formamide; at 158℃; for 3h;sealed vessel;	2,5-Dibromo-4-methylpyridine(5.0 g, 19.9 mmol), copper cyanide (1.43 g, 15.9 mmol), sodium cyanide (0.801 g, 16.3 mmol) and dimethylformamide (30 mL) were combined in a sealed reaction vessel and heated at 158 0C for 3 h. The reaction mixture was purified by silica gel column chromatography (0-80 % ethyl acetate in hexanes). The resulting material was subjected to a second silica gel column (0-20 % methanol in dichloromethane). Clean fractions were combined and concentrated to afford the title compound as a white solid (2.3O g, 11.6 mmol, 58 % yield). MS (ESI) m/z 198.0 [M+l]+.
42.4%	In N,N-dimethyl-formamide; for 20h;Reflux;	5-bromo-4-methyl-pyridine-2-carbonitrile: To a solution of 2,5-dibromo-4-methylpyridine (15 g, 59.8 mmol, Eq: 1.00) in DMF (100 ml) was added copper(I) cyanide (4.28 g, 47.8 mmol, Eq: 0.8) and sodium cyanide (2.34 g, 47.8 mmol, Eq: 0.8). The reaction mixture was refluxed for 20 hr at which point a precipitate formed. Upon cooling water was added and the mixture sonicated. The solids were filtered and washed with water. The resulting filtrate was extracted with EtOAc and the organic layers then combined, washed with water and brine, and concentrated under reduced pressure. The crude material was then purified by column chromatography (0-10% EtOAc/Hex gradient) to give 5-bromo-4-methyl-pyridine-2-carbonitrile (5 g, 42.4% yield) as a white solid.

Reference： [1]Patent: WO2010/62571,2010,A1 .Location in patent: Page/Page column 96
[2]Patent: US2013/90333,2013,A1 .Location in patent: Paragraph 0184

5
[ 886364-86-9 ]
1-(((trans)-4-methoxycyclohexyl)methyl)-7-(trimethylstannyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one [ No CAS ]
5-(8-(((trans)-4-methoxycyclohexyl)methyl)-7-oxo-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl)-4-methylpicolinonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine;tris-(dibenzylideneacetone)dipalladium(0); tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 100℃; for 3h;sealed vessel; Inert atmosphere;	1 -(((trans)-4- Methoxycyclohexyl)methyl)-7-(trimethylstannyl)-3,4-dihydropyrazino[2,3-b]pyrazin- 2(lH)-one (0.721 g, 1.64 mmol), <strong>[886364-86-9]5-bromo-4-methylpicolinonitrile</strong> (0.323 g, 1.64 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.150 g, 0.164 mmol), triethylamine (0.687 mL, 4.93 mmol), tri-ortho-toylphosphine (0.100 g, 0.328 mmol) and dimethylformamide (8 mL) were combined in a sealed reaction vessel. Nitrogen was bubbled through the reaction for 5 min and reaction was heated at 100 0C for 3 h. Reaction is filtered, concentrated and purified by silica gel column chromatography (0-80 % ethyl acetate in hexanes). Fractions were combined and concentrated to afford the crude title compound used directly for next step (0.607 g, 1.55 mmol, 94 % yield). MS (ESI) m/z 393.5 [M+l]+.

Reference： [1]Patent: WO2010/62571,2010,A1 .Location in patent: Page/Page column 98

6
[ 75-89-8 ]
[ 886364-86-9 ]
[ 1373864-22-2 ]

Yield	Reaction Conditions	Operation in experiment
8%	With copper(l) iodide; 1,10-Phenanthroline; for 3h;microwave irradiation;	A mixture of <strong>[886364-86-9]5-bromo-4-methylpicolinonitrile</strong> (0.30 g, 1.52 mmol), 2,2,2-trifluoroethanol (0.55 mL, 7.61 mmol), copper(I) iodide (0.029 g, 0.152 mmol), 1,10-phenanthroline (0.03 g, oCoC for 3 hours under microwave irradiation. The reaction mixture is poured into water, extracted with ethyl acetate and dried over sodium sulfate and concentrated in vacuo. The residue is purified by column chromatography on silica gel eluting with n-hexane / ethyl acetate (4:1) to give 26.5 mg (8% yield) of the title compound as colorless oil.1H-NMR (300 MHz, CDCl3) delta 8.22 (1H, s), 7.55 (1H, s), 4.53 (2H, q, J = 7.7 Hz), 2.34 (3H, s), MS (ESI) m/z: 217 (M+H)+.

Reference： [1]Patent: WO2012/53186,2012,A1 .Location in patent: Page/Page column 158-159

7
[ 886364-86-9 ]
[ 75-16-1 ]
[ 1413285-68-3 ]

Yield	Reaction Conditions	Operation in experiment
		Compound 5-bromo-4-methyl -pyridine -2 -carbonitrile (450mg) dissolved in 5 ml of THF was added to a solution of CH3MgBr (2 ml, 2.8 mol/L in THF) in 5 ml of THF at 0C. After stirring for 1 h, the reaction mixture was poured into aqueous NH4C1, and extracted with ethyl acetate three times. The combined organic layers were washed with brine, dried over anhydrous Na2S04 and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel to give the title compound (356mg). lU NMR (300MZ, CDC13): delta 2.47 (s, 3H), 2.70 (s, 3H), 7.91 (s, 1H), 8.69 (s, 1H).

Reference： [1]Patent: WO2012/156400,2012,A1 .Location in patent: Page/Page column 210

8
[ 886364-86-9 ]
[ 1309959-26-9 ]

Reference： [1]Patent: WO2012/156400,2012,A1

9
[ 886364-86-9 ]
[ 1413285-69-4 ]

Reference： [1]Patent: WO2012/156400,2012,A1

10
[ 886364-86-9 ]
[ 1413285-70-7 ]

Reference： [1]Patent: WO2012/156400,2012,A1

11
[ 886364-86-9 ]
[ 1429341-53-6 ]

Reference： [1]Patent: US2013/90333,2013,A1
[2]Patent: US2013/90334,2013,A1

12
[ 886364-86-9 ]
[ 1427171-69-4 ]
[ 1427172-14-2 ]

Reference： [1]Journal of Medicinal Chemistry,2013,vol. 56,p. 2642 - 2650

13
[ 886364-86-9 ]
[ 1429341-52-5 ]

Yield	Reaction Conditions	Operation in experiment
80%	With sodium azide; triethylamine hydrochloride; In 5,5-dimethyl-1,3-cyclohexadiene; at 140℃;	5-bromo-4-methyl-2-(2H-tetrazol-5-yl)-pyridine: To a mixture of <strong>[886364-86-9]5-bromo-4-methylpicolinonitrile</strong> (2.5 g, 12.7 mmol, Eq: 1.00), sodium azide (1.07 g, 16.5 mmol, Eq: 1.3) and triethylamine hydrochloride (2.27 g, 16.5 mmol, Eq: 1.3) was added xylene (25 ml). The reaction mixture was heated at 140 C. overnight, and upon cooling was concentrated under reduced pressure. To the white residue was added water and an aq. HCl solution. These solids were filtered, washed with water, and dried to give 5-bromo-4-methyl-2-(2H-tetrazol-5-yl)-pyridine (2.43 g, 80% yield) as an off-white solid.
80%	With sodium azide; triethylamine hydrochloride; In 5,5-dimethyl-1,3-cyclohexadiene; at 140℃;	5-bromo-4-methyl-2-(2H-tetrazol-5-yl)-pyridine:To a mixture of <strong>[886364-86-9]5-bromo-4-methylpicolinonitrile</strong> (2.5 g, 12.7 mmol, Eq: 1.00), sodium azide (1.07 g, 16.5 mmol, Eq: 1.3) and triethylamine hydrochloride (2.27 g, 16.5 mmol, Eq: 1.3) was added xylene (25 ml). The reaction mixture was heated at 140 C. overnight, and upon cooling was concentrated under reduced pressure. To the white residue was added water and an aq. HCl solution. These solids were filtered, washed with water, and dried to give 5-bromo-4-methyl-2-(2H-tetrazol-5-yl)-pyridine (2.43 g, 80% yield) as an off-white solid.

Reference： [1]Patent: US2013/90333,2013,A1 .Location in patent: Paragraph 0185
[2]Patent: US2013/90334,2013,A1 .Location in patent: Paragraph 0154

14
[ 773837-37-9 ]
[ 3430-26-0 ]
[ 886364-86-9 ]

Yield	Reaction Conditions	Operation in experiment
42.4%	With copper(l) cyanide; In N,N-dimethyl-formamide; for 20h;Reflux;	5-bromo-4-methyl-pyridine-2-carbonitrile:To a solution of 2,5-dibromo-4-methylpyridine (15 g, 59.8 mmol, Eq: 1.00) in DMF (100 ml) was added copper(1) cyanide (4.28 g, 47.8 mmol, Eq: 0.8) and sodium cyanide (2.34 g, 47.8 mmol, Eq: 0.8). The reaction mixture was refluxed for 20 hr at which point a precipitate formed. Upon cooling water was added and the mixture sonicated. The solids were filtered and washed with water. The resulting filtrate was extracted with EtOAc and the organic layers then combined, washed with water and brine, and concentrated under reduced pressure. The crude material was then purified by column chromatography (0-10% EtOAc/Hex gradient) to give 5-bromo-4-methyl-pyridine-2-carbonitrile (5 g, 42.4% yield) as a white solid.

Reference： [1]Patent: US2013/90334,2013,A1 .Location in patent: Paragraph 0153

15
[ 886364-86-9 ]
[ 73183-34-3 ]
4-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide; at 90℃; for 6h;Inert atmosphere;	Step 1: A suspension of <strong>[886364-86-9]5-bromo-4-methylpyridine-2-carbonitrile</strong> (CAS 886364-86-9, 5.0 g, 25.4 mmol), PdCl2(dppf) (0.928 g, 1.269 mmol), bis(pinacolato)diboron (9.02 g, 35.5 mmol) and potassium acetate (4.98 g, 50.8 mmol) in dry DMSO (34 mL) was degassed (vacuum / nitrogen cycles) and heated under nitrogen at 90 C for 6 h. The reaction was partitioned between EtOAc and brine and separated. The aqueous was extracted further with EtOAc. The combined organics were washed with brine, dried (phase separator) and concentrated in vacuo. The crude product was purified by flash chromatography (0-30% EtOAc in heptane on Si02) to afford 4-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carbonitrile. MS ES+: 245

Reference： [1]Patent: WO2016/148306,2016,A1 .Location in patent: Page/Page column 221-222

16
[ 886364-86-9 ]
N-[5-(6-cyano-4-methylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]acetamide [ No CAS ]

Reference： [1]Patent: WO2016/148306,2016,A1

17
[ 886364-86-9 ]
5-{7-amino-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-4-methylpyridine-2-carbonitrile [ No CAS ]

Reference： [1]Patent: WO2016/148306,2016,A1

18
[ 886364-86-9 ]
5-{7-chloro-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-4-methylpyridine-2-carbonitrile [ No CAS ]

Reference： [1]Patent: WO2016/148306,2016,A1

19
[ 98198-48-2 ]
[ 886364-86-9 ]

Reference： [1]Patent: WO2008/124610,2008,A1
[2]Patent: WO2008/124614,2008,A1

20
[ 3430-26-0 ]
[ 886364-86-9 ]

Reference： [1]Patent: WO2008/124610,2008,A1
[2]Patent: WO2008/124614,2008,A1

21
[ 886364-86-9 ]
[ 1070889-97-2 ]

Reference： [1]Patent: WO2008/124610,2008,A1

22
[ 886364-86-9 ]
[ 1070890-06-0 ]

Reference： [1]Patent: WO2008/124610,2008,A1

23
[ 886364-86-9 ]
[ 1070973-11-3 ]

Reference： [1]Patent: WO2008/124614,2008,A1

24
[ 886364-86-9 ]
[ 1070973-10-2 ]

Reference： [1]Patent: WO2008/124614,2008,A1

25
[ 886364-86-9 ]
(±)-[8-chloro-3-[[(trans)-2-cyanocyclopropanecarbonyl]amino]-6-isoquinolyl]boronic acid [ No CAS ]
(±)-(trans)-N-(8-chloro-6-(6-cyano-4-methylpyridin-3-yl)isoquinolin-3-yl)-2-cyanocyclopropane-1-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
187 mg	With sodium carbonate; In 1,4-dioxane; water; at 90℃; for 0.916667h;Microwave irradiation;	A mixture of (±)-trans-N-(6-bromo-8-chloroisoquinolin-3-yl)-2-cyanocyclopropane-1-carboxamide (125 mg, 0.571 mmol), bis(pinacolato)diboron (222 mg, 0.856 mmol), potassium acetate (168 mg, 1.711 mmol), and Pd(dppf)Cl2 (42.2 mg, 0.0571 mmol) in 1,4-dioxane (3 mL) was heated in a microwave at 130 C. for 45 minutes to give (±)-(8-chloro-3-((trans-2-cyanocyclopropane-1-carboxamido)isoquinolin-6-yl)boronic acid. LCMS (ESI): [M+H]+=316.0. (0975) 5-Bromo-4-methylpicolinonitrile (168 mg, 0.856 mmol) and sodium carbonate (1 mol/L) in water (2.85 ml, 2.852 mmol) were then added. The reaction mixture was heated in a microwave at 90 C. for 55 minutes. The organic layer was purified with silica gel column chromatography (0.5 to 9% methanol in dichloromethane) to give (±)-(trans-N-(8-chloro-6-(6-cyano-4-methylpyridin-3-yl)isoquinolin-3-yl)-2-cyanocyclopropane-1-carboxamide (187 mg, 86.5% yield). LCMS (ESI) [M+H]+=388.0.

Reference： [1]Patent: US2018/282282,2018,A1 .Location in patent: Paragraph 0974; 0975

26
[ 886364-86-9 ]
tert-butyl N-[6-[(6-cyano-4-methyl-3-pyridyl)oxy]-2-(methylamino)-3-nitro-4-pyridyl]carbamate [ No CAS ]

Reference： [1]Patent: WO2019/76716,2019,A1

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P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 886364-86-9 ]

Quality Control of [ 886364-86-9 ]

Related Doc. of [ 886364-86-9 ]

Product Details of [ 886364-86-9 ]

Safety of [ 886364-86-9 ]

Application In Synthesis of [ 886364-86-9 ]

[ 886364-86-9 ] Synthesis Path-Upstream 1~5

[ 886364-86-9 ] Synthesis Path-Downstream 1~26

Related Functional Groups of [ 886364-86-9 ]

Nitriles

Bromides

Related Parent Nucleus of [ 886364-86-9 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 886364-86-9 ]

Related Parent Nucleus of
[ 886364-86-9 ]