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[ CAS No. 886365-06-6 ]

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Chemical Structure| 886365-06-6
Chemical Structure| 886365-06-6
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CAS No. :886365-06-6 MDL No. :MFCD07375102
Formula : C8H8BrNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :230.06 g/mol Pubchem ID :56763836
Synonyms :

Safety of [ 886365-06-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 886365-06-6 ]

  • Upstream synthesis route of [ 886365-06-6 ]
  • Downstream synthetic route of [ 886365-06-6 ]

[ 886365-06-6 ] Synthesis Path-Upstream   1~5

  • 1
  • [ 886365-06-6 ]
  • [ 886365-02-2 ]
Reference: [1] Patent: WO2012/143329, 2012, A1, . Location in patent: Page/Page column 142-143
  • 2
  • [ 67-56-1 ]
  • [ 886365-02-2 ]
  • [ 886365-06-6 ]
YieldReaction ConditionsOperation in experiment
49% for 14 h; Reflux To a solution of 5-Bromo-4-methyl-pyridine-2-carboxylic acid (650 mg, 3.0 mmol) in MeOH (2 ml) was added conc. H2SO4 (0.06 ml).
The mixture was refluxed for 14 h, after which it was cooled to 0° C., neutralized with saturated NaHCO3, filtered, concentrated, and purified by column chromatography to give 5-Bromo-4-methyl-pyridine-2-carboxylic acid methyl ester (340 mg, 49percent) as white solid.
49% for 14 h; Reflux To a solution of 5-Bromo-4-methyl-pyridine-2-carboxylic acid (650 mg, 3.0 mmol) in MeOH (2 ml) was added conc. H2SO4 (0.06 ml).
The mixture was refluxed for 14 h, after which it was cooled to 0° C., neutralized with saturated NaHCO3, filtered, concentrated, and purified by column chromatography to give 5-Bromo-4-methyl-pyridine-2-carboxylic acid methyl ester (340 mg, 49percent) as white solid.
49% for 14 h; Reflux To a solution of 5-Bromo-4-methyl-pyridine-2-carboxylic acid (650 mg, 3.0 mmol) in MeOH (2 ml) was added conc. H2SO4 (0.06 ml).
The mixture was refluxed for 14 h, after which it was cooled to 0° C., neutralized with saturated NaHCO3, filtered, concentrated, and purified by column chromatography to give 5-Bromo-4-methyl-pyridine-2-carboxylic acid methyl ester (340 mg, 49percent) as white solid.
49% for 14 h; Reflux To a solution of 5-Bromo-4-methyl-pyridine-2-carboxylic acid (650 mg, 3.0 mmol) in MeOH (2 ml) was added conc. H2SO4 (0.06 ml).
The mixture was refluxed for 14 h, after which it was cooled to 0° C., neutralized with saturated NaHCO3, filtered, concentrated, and purified by column chromatography to give 5-Bromo-4-methyl-pyridine-2-carboxylic acid methyl ester (340 mg, 49percent) as white solid.

Reference: [1] Patent: US2011/71150, 2011, A1, . Location in patent: Page/Page column 34
[2] Patent: US2013/158040, 2013, A1, . Location in patent: Paragraph 0135
[3] Patent: US2013/158049, 2013, A1, . Location in patent: Paragraph 0169
[4] Patent: US2013/158066, 2013, A1, . Location in patent: Paragraph 0135
  • 3
  • [ 3430-26-0 ]
  • [ 886365-06-6 ]
Reference: [1] Patent: US2011/71150, 2011, A1,
[2] Patent: US2013/158040, 2013, A1,
[3] Patent: US2013/158049, 2013, A1,
[4] Patent: US2013/158066, 2013, A1,
  • 4
  • [ 67-56-1 ]
  • [ 1122090-38-3 ]
  • [ 886365-06-6 ]
Reference: [1] Patent: WO2012/143329, 2012, A1, . Location in patent: Page/Page column 142
  • 5
  • [ 1122090-37-2 ]
  • [ 886365-06-6 ]
Reference: [1] Patent: US2011/71150, 2011, A1,
[2] Patent: WO2012/143329, 2012, A1,
[3] Patent: US2013/158040, 2013, A1,
[4] Patent: US2013/158049, 2013, A1,
[5] Patent: US2013/158066, 2013, A1,
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