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[ CAS No. 886365-48-6 ]

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Chemical Structure| 886365-48-6
Chemical Structure| 886365-48-6
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Product Details of [ 886365-48-6 ]

CAS No. :886365-48-6 MDL No. :MFCD07374402
Formula : C9H11BrN2 Boiling Point : 298°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :227.10 g/mol Pubchem ID :67294409
Synonyms :

Safety of [ 886365-48-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P301+P310-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 886365-48-6 ]

  • Downstream synthetic route of [ 886365-48-6 ]

[ 886365-48-6 ] Synthesis Path-Downstream   1~3

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  • [ 24424-99-5 ]
  • [ 886365-48-6 ]
  • [ 1454908-10-1 ]
YieldReaction ConditionsOperation in experiment
500 mg With triethylamine; In dichloromethane; at 20.0℃; for 16.0h; Step 1 Preparation of 2-(5-Bromo-pyridin-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester A solution of 5-Bromo-2-pyrrolidin-2-yl-pyridine (611 mg, 2.69 mmol) (previously described in WO200853319) in CH2Cl2 (20 ml) is treated with di-tert-butyl dicarbonate (881 mg, 4.04 mmol) and triethylamine (0.562 ml, 4.04 mmol), and stirred at ambient temperature for 16 hours. The reaction mixture is washed with 10percent aqueous citric acid solution (25 ml). The organic phase is concentrated on to silica gel (5 g) and purified by column chromatography (40 g silica gel, ethyl acetate/heptane 0-50percent) to afford the title compound (500 mg): 1H NMR (400 MHz, CDCl3) 1.23 (s, 5H), 1.4 5 (s, 4H), 1.82-2.09 (m, 3H), 2.24-2.43 (m, 1H), 3.47-3.74 (m, 2H), 4.67-4.99 (m, 1H), 7.05-7.14 (m, 1H), 7.71-7.78 (m, 1H), 8.59 (dd, 1H). m/z M+H 327.
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  • [ 1454908-11-2 ]
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