[ CAS No. 886444-12-8 ]

Name: 886444-12-8|2-(2-Fluorophenyl)-4-methylpyridine|95%
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Product Details of [ 886444-12-8 ]

CAS No. :	886444-12-8	MDL No. :	MFCD09031941
Formula :	C₁₂H₁₀FN	Boiling Point :	277.5°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	187.21 g/mol	Pubchem ID :	23061526
Synonyms :

Safety of [ 886444-12-8 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 886444-12-8 ]

Upstream synthesis route of [ 886444-12-8 ]
Downstream synthetic route of [ 886444-12-8 ]

[ 886444-12-8 ] Synthesis Path-Upstream 1~2

1
[ 14221-01-3 ]
[ 1993-03-9 ]
[ 886444-12-8 ]

Reference： [1] Patent: US2007/37974, 2007, A1, . Location in patent: Page/Page column 23

2
[ 67-56-1 ]
[ 886444-12-8 ]
[ 100004-77-1 ]

Reference： [1] Chemical Science, 2013, vol. 5, # 1, p. 275 - 280

[ 886444-12-8 ] Synthesis Path-Downstream 1~9

1
[ 886444-12-8 ]
[ 2524-52-9 ]
[ 886444-14-0 ]

Reference： [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 2210 - 2221

2
[ 886444-12-8 ]
(E)-3-Dimethylamino-2-[2-(2-fluoro-phenyl)-pyridin-4-yl]-1-pyridin-2-yl-propenone [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 2210 - 2221

3
[ 886444-12-8 ]
2-(2-Fluoro-phenyl)-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)-pyridine [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 2210 - 2221

4
[ 14221-01-3 ]
[ 1993-03-9 ]
[ 886444-12-8 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium carbonate; In ethanol; diethylene glycol dimethyl ether; at 88℃; for 4h;	(B) To a solution of intermediate XXXIIa (1 g) and 2-fluorophenyl boronic acid (1.5 g) in diglyme/EtOH (21 ml of 20:1) was added a solution of Na2CO3 (sat'd, 3 ml), followed by tetrakis(triphenylphosphine) palladium (0) (0.2 g). The mixture was heated at 88 C. for 4 h, cooled to RT, and purified to provide 2-(2-fluorophenyl)-4-methylpyridine (intermediate XXXIIb, 0.97 g).

Reference： [1]Patent: US2007/37974,2007,A1 .Location in patent: Page/Page column 23

5
[ 886444-12-8 ]
[ 924645-91-0 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium permanganate; In water; for 20h;Heating / reflux;	(C) To a suspension of intermediate XXXIIb (0.44 g, 2.35 mmol) in water (25 ml) was added KMnO4 (0.82 g, 5.18 mmol) in two portions, the mixture heated at reflux for 20 h, cooled to RT. The resulting solid was filtered through celite, washed with water and EtOAc, and the two phases separated. The pH of aqueous solution was adjusted to 3, and the white precipitate that formed was isolated and dried to yield 2-(2-fluorophenyl)-pyridine-4-carboxylic acid (intermediate XXXIIc, 0.17 g, 33%). MW+1:218, MW-1:216.

Reference： [1]Patent: US2007/37974,2007,A1 .Location in patent: Page/Page column 23

6
2-(2-bromophenyl)-4-methylpyridine [ No CAS ]
[ 886444-12-8 ]

Reference： [1]Chemical Science,2013,vol. 5,p. 275 - 280

7
2-(2-bromophenyl)-4-methylpyridine [ No CAS ]
[ 886444-12-8 ]
C₂₄H₂₀N₂⁽¹⁶⁾O [ No CAS ]

Reference： [1]Chemical Science,2013,vol. 5,p. 275 - 280

8
2-(2-bromophenyl)-4-methylpyridine [ No CAS ]
[ 886444-12-8 ]
C₂₄H₂₀N₂⁽¹⁸⁾O [ No CAS ]

Reference： [1]Chemical Science,2013,vol. 5,p. 275 - 280

9
[ 67-56-1 ]
2-(2-bromophenyl)-4-methylpyridine [ No CAS ]
[ 886444-12-8 ]
[ 100004-77-1 ]

Reference： [1]Chemical Science,2013,vol. 5,p. 275 - 280

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P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
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P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
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P501	Dispose of contents/container to ...
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
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H221	Flammable gas
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H231	May react explosively even in the absence of air at elevated pressure and/or temperature
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H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
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H252	Self-heating in large quantities; may catch fire
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H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
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H336	May cause drowsiness or dizziness
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H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 886444-12-8 ]

Quality Control of [ 886444-12-8 ]

Related Doc. of [ 886444-12-8 ]

Product Details of [ 886444-12-8 ]

Safety of [ 886444-12-8 ]

Application In Synthesis of [ 886444-12-8 ]

[ 886444-12-8 ] Synthesis Path-Upstream 1~2

[ 886444-12-8 ] Synthesis Path-Downstream 1~9

Related Functional Groups of [ 886444-12-8 ]

Fluorinated Building Blocks

Aryls

Related Parent Nucleus of [ 886444-12-8 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

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Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 886444-12-8 ]

Related Parent Nucleus of
[ 886444-12-8 ]