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[ CAS No. 886499-21-4 ]

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Chemical Structure| 886499-21-4
Chemical Structure| 886499-21-4
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Product Details of [ 886499-21-4 ]

CAS No. :886499-21-4 MDL No. :MFCD04039212
Formula : C7H4BrF3N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :301.02 g/mol Pubchem ID :2782668
Synonyms :

Safety of [ 886499-21-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 886499-21-4 ]

  • Downstream synthetic route of [ 886499-21-4 ]

[ 886499-21-4 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 886499-21-4 ]
  • [ 1326311-36-7 ]
YieldReaction ConditionsOperation in experiment
41% Step A{2-amino-3-bromo-5-[(trifluoromethyl)oxy]p enyl}amine[00345] A solution of <strong>[886499-21-4]{2-bromo-6-nitro-4-[(trifluoromethyl)oxy]phenyl}amine</strong> (5.00 g, 16.6 mmol, Matrix Scientific) in ethanol (100 mL) was treated with a solution of sodium dithionite (11.6 g, 66.4 mmol) in water (50 mL) and allowed to stir at rt overnight. A second portion of sodium dithionite (5.80 g, 33.2 mmol) was added as a solution in water and the reaction was stirred for an additional 2 h. The reaction mixture was concentrated to remove some of the ethanol, then diluted with water and extracted with ethyl acetate (2x). The combined organic layers were washed with saturated aqueous ammonium chloride (2x), 10% aqueous sodium carbonate (1x) and brine (1x). After drying over sodium sulfate, the solution was concentrated to a brown oil. This was slurried in diethyl ether and treated with 4 N HCI in dioxane. The mixture was filtered and the solids rinsed with diethyl ether to afford the title compound as the HCI salt (2.08 g, 41 %).
  • 2
  • [ 886499-21-4 ]
  • [ 1326311-37-8 ]
  • 3
  • [ 886499-21-4 ]
  • 4-({4-bromo-6-[(trifluoromethyl)oxy]-1H-benzimidazol-2-yl}carbonyl)-1-(trans-4-hydroxycyclohexyl)-2-piperazinone [ No CAS ]
  • 4
  • [ 886499-21-4 ]
  • 4-({4-bromo-6-[(trifluoromethyl)oxy]-1H-benzimidazol-2-yl}carbonyl)-1-(trans-4-[(1,1-dimethylethyl)(dimethyl)silyl]oxy}cyclohexyl)-2-piperazinone [ No CAS ]
  • 5
  • [ 886499-21-4 ]
  • 4-({4-bromo-1-methyl-6-[(trifluoromethyl)oxy]-1H-benzimidazol-2-yl}carbonyl)-1-(trans-4-[(1,1-dimethylethyl)(dimethyl)silyl]oxy}cyclohexyl)-2-piperazinone [ No CAS ]
  • 6
  • [ 886499-21-4 ]
  • 4-({4-bromo-1-methyl-6-[(trifluoromethyl)oxy]-1H-benzimidazol-2-yl}carbonyl)-1-(trans-4-hydroxycyclohexyl)-2-piperazinone [ No CAS ]
  • 7
  • [ 886499-21-4 ]
  • 4-({4-(3-fluorophenyl)-1-methyl-6-[(trifluoromethyl)oxy]-1H-benzimidazol-2-yl}carbonyl)-1-(trans-4-hydroxycyclohexyl)-2-piperazinone [ No CAS ]
  • 8
  • [ 886499-21-4 ]
  • C32H40F4N4O4Si [ No CAS ]
  • 9
  • [ 886499-21-4 ]
  • 4-({4-cyclopropyl-1-methyl-6-[(trifluoromethyl)oxy]-1H-benzimidazol-2-yl}carbonyl)-1-(trans-4-hydroxycyclohexyl)-2-piperazinone [ No CAS ]
  • 10
  • [ 886499-21-4 ]
  • C29H41F3N4O4Si [ No CAS ]
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