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[ CAS No. 886501-36-6 ]

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Chemical Structure| 886501-36-6
Chemical Structure| 886501-36-6
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Product Details of [ 886501-36-6 ]

CAS No. :886501-36-6 MDL No. :MFCD06740104
Formula : C11H12ClNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :225.67 g/mol Pubchem ID :7148607
Synonyms :

Safety of [ 886501-36-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 886501-36-6 ]

  • Downstream synthetic route of [ 886501-36-6 ]

[ 886501-36-6 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 110-91-8 ]
  • [ 84194-36-5 ]
  • [ 886501-36-6 ]
  • 2
  • [ 886501-36-6 ]
  • [ 60933-65-5 ]
  • (R)-7-morpholino-2,1-benzothiazine [ No CAS ]
  • 3
  • [ 886501-36-6 ]
  • [ 169447-70-5 ]
  • [ 1446819-07-3 ]
YieldReaction ConditionsOperation in experiment
74% A 100 mL round-bottom flask was charged with 2-chloro-4-(morpholin-4- yl)benzaldehyde (0.800 g, 3.54 mmol, 1.00 equiv), tert-butyl (2S)-2-methylpiperazine-l- carboxylate (0.783 g, 3.91 mmol, 1.10 equiv) , 1,2-dichloroethane (20 mL). The mixture was stirred for 30 min at room temperature. Sodium triacetoxyborohydride (2.26 g, 10.7 mmol, 3.00 equiv) was added. The resulting solution was stirred overnight at room temperature, diluted with ]0 (30 mL), extracted with dichloromethane (3 x 30 mL) and the organic layers were combined, dried over Na2S04, filtered and concentrated under reduced pressure. The residue was chromatographed on a silia gel column with ethyl acetate/petroleum ether (25/75) to provide 1.20 g (74% yield) of tert-butyl (2S)-4-[[2-chloro-4-(morpholin-4- yl)phenyl]methyl]-2-methylpiperazine-l-carboxylate as a white solid. LCMS (ESI, m/z): 410 [M+H]+.
74% Step 1: Preparation of tert-butyl (2S)-4-[[2-chloro-4-(morpholin-4-yl)phenyl]methyl]-2- methylpiperazine-l-carboxylate [00254] A 100-mL round-bottom flask was charged with 2-chloro-4-(morpholin-4- yl)benzaldehyde (0.800 g, 3.54 mmol, 1.00 equiv), tert-butyl (2S)-2-methylpiperazine-l- carboxylate (0.783 g, 3.91 mmol, 1.10 equiv), and 1,2-dichloroethane (20 mL). The mixture was stirred for 30 min at room temperature. Sodium triacetoxyborohydride (2.26 g, 10.7 mmol, 3.00 equiv) was added. The resulting solution was stirred overnight at room temperature, diluted with 0 (30 mL), extracted with dichloromethane (3 x 30 mL), and the organic layers were combined, dried over Na2S04, filtered, and concentrated under reduced pressure. The residue was chromatographed on a silia gel column with ethyl acetate/petroleum ether (25/75) to provide 1.20 g (74% yield) of tert-butyl (2S)-4-[[2-chloro-4-(morpholin-4- yl)phenyl]methyl]-2-methylpiperazine-l -carboxylate as a white solid. LCMS (ESI, m/z): 410 [M+H]+.
  • 4
  • [ 886501-36-6 ]
  • [ 1446817-79-3 ]
  • 5
  • [ 886501-36-6 ]
  • [ 1446819-08-4 ]
  • 6
  • [ 886501-36-6 ]
  • [ 1460031-02-0 ]
  • 7
  • [ 886501-36-6 ]
  • [ 106-49-0 ]
  • [ 105-45-3 ]
  • C41H44Cl2N4O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% With Ag NPs decorated reduced graphene oxide; In methanol; at 20℃; for 0.783333h;Sonication; General procedure: An equimolar mixture of aromatic aldehyde (2 mmol), methyl acetoacetate (1 mmol), aromatic amines (2 mmol), and 5 wt% Ag NPs/rGO nanocomposite in 5 mL methanol was introduced in a 20 mL heavy walled pear-shaped twonecked flask with non-standard tapered outer joint. The flask was attached to a 12 mm tip diameter probe and the reaction mixture was sonicated at an ambient temperature for the specified period at 50% power of the processor and in a 4 s pulse mode till a solid product separates out. When the reaction was completed, the resulting solid precipitate was filtered and dried along with the catalyst. Then, the solid precipitate was dissolved in acetone and the catalyst was recovered by filtration. This solution was concentrated at room temperature to generate the crude product. The crude product was purified by crystallization from ethanol.
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