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[ CAS No. 886503-52-2 ]

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Chemical Structure| 886503-52-2
Chemical Structure| 886503-52-2
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Product Details of [ 886503-52-2 ]

CAS No. :886503-52-2 MDL No. :MFCD06660317
Formula : C9H7F3O3 Boiling Point : 253.5°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :220.15 g/mol Pubchem ID :17750806
Synonyms :

Safety of [ 886503-52-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 886503-52-2 ]

  • Downstream synthetic route of [ 886503-52-2 ]

[ 886503-52-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 886503-52-2 ]
  • [ 1241827-72-4 ]
YieldReaction ConditionsOperation in experiment
With hydroxylamine hydrochloride; potassium acetate; In ethanol; at 50.0℃; for 5.0h; Example 67: (4-methoxy-2-(trifluoromethoxy)phenyl)methanamine; [0216] To a mixture of <strong>[886503-52-2]4-methoxy-2-(trifluoromethoxy)benzaldehyde</strong> (10Og, 450 mmol) in 1000 mL of EtOH was added hydroxylamine hydrochloride (38 g, 550 mmol) and potassium acetate (49 g, 500 mmol). The mixture was stirred at 500C for 5 h. The solvent was then removed on rotoray evaporator to give a white solid which was collected by filtration and washed with 2 potions of water. The solid product was dried overnight in vacuum to give 81 grams of the crude <strong>[886503-52-2]4-methoxy-2-(trifluoromethoxy)benzaldehyde</strong> oxime (yield: 75%) that was used in next step without purification.[0217] To a solution of 80 g of <strong>[886503-52-2]4-methoxy-2-(trifluoromethoxy)benzaldehyde</strong> oxime in 1000 mL of MeOH was added 70 g of Zn dust and 126 g of ammonium formate. The mixture was stirred at room temperature for 5 h, then the mixture was filtered and the filtrate was evaporated under reduced pressure to give a residue. The residue was combined with 1 L of water and the pH was adjusted to 3-3.5. The aqueous phase was washed with 300 mL OfEt2O. Then the aqueous phase was made basic (pH 11-12) and was extracted with two portions 300 mL OfEt2O. After drying over K2CO3/Na2SO4, the solvent was evaporated on rotoray evaporator to give 36 g (yield: 48%) of the title compound which was used without purification. 1H NMR (400 MHz, MeOH-d4) delta: 7.52 (d, J = 8.59 Hz, IH), 7.03 (dd, J = 8.59, 2.53 Hz, IH), 6.95 (s, IH), 4.13 (s, 2H), 3.85 (s, 3H). [M+H] calc'd for C9Hi0F3NO2, 222; Found, 222.
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