* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With sodium cyanoborohydride In 1,2-dichloro-ethane at 20℃; for 2h; Inert atmosphere;
Step 5. (3-isopropoxyphenyl)(piperidin-3-yl)methanone (200 mg, 0.768 mmol) and 5-methyl-1-propyl-1H-pyrazole-4-carbaldehyde (140 mg, 0.922 mmol) were added to a25-mL flask with stir bar and sealed under N2. DCE (3.8 mL) was added to give a yellow solution, then sodium triacetoxyborohydride (228 mg, 1.075 mmol) was added and the reaction was stirred at room temperature. After 2 h, the reaction was diluted with halfsaturatedaq. NaHCO3 (approximately 40 mL) and EtOAc (approximately 40 mL). Thel ayers were separated and the combined organic layers were washed with aqueous NaHCO3 (1 x 20 mL), then brine (1 x 20 mL), dried over Na2SO4, filtered, and concentrated. Purification by column chromatography provided 13a as colorless oil, 194 mg, 66% yield.
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
Life Science
For Research Only
100K+ Compounds
Competitive Price
1-2 Day Shipping
