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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 892686-59-8 Chemical Structure| 892686-59-8

Structure of BD750
CAS No.: 892686-59-8

Chemical Structure| 892686-59-8

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BD750 inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation. Treatment with BD750 induced tolDC that inhibited pro-inflammatory T cell immunity in vitro and in vivo.

4.5 *For Research Use Only !

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Product Details of BD750

CAS No. :892686-59-8
Formula : C14H13N3OS
M.W : 271.34
SMILES Code : OC1=C2CCCCC2=NN1C3=NC4=CC=CC=C4S3
MDL No. :MFCD08132253
InChI Key :QWUHPPCZZXKXOQ-UHFFFAOYSA-N
Pubchem ID :16459674

Safety of BD750

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P264-P270-P301+P310-P321-P330-P405-P501
Class:6.1
UN#:2811
Packing Group:

Related Pathways of BD750

epigenetics
RTK
JAK-STAT

Isoform Comparison

Biological Activity

Description
BD750, a potent immunosuppressant and JAK3/STAT5 inhibitor, suppresses IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM in mouse T cells and 1.1 μM in human T cells[1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.69mL

0.74mL

0.37mL

18.43mL

3.69mL

1.84mL

36.85mL

7.37mL

3.69mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

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