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[ CAS No. 89434-03-7 ]

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Chemical Structure| 89434-03-7
Chemical Structure| 89434-03-7
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Product Details of [ 89434-03-7 ]

CAS No. :89434-03-7 MDL No. :MFCD04972068
Formula : C10H8FNO2 Boiling Point : 417.867°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :193.17 g/mol Pubchem ID :-
Synonyms :

Safety of [ 89434-03-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 89434-03-7 ]

  • Downstream synthetic route of [ 89434-03-7 ]

[ 89434-03-7 ] Synthesis Path-Downstream   1~17

  • 2
  • [ 89434-05-9 ]
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  • [ 4769-97-5 ]
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  • [ 4770-06-3 ]
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  • [ 7150-46-1 ]
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  • 9
  • [ 101909-46-0 ]
  • [ 89434-03-7 ]
  • 10
  • [ 89245-39-6 ]
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  • 11
  • [ 89245-40-9 ]
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  • 12
  • 3-cyanomethyl-1-methoxycarbonyl-4-indolediazonium tetrafluoroborate [ No CAS ]
  • [ 89434-03-7 ]
  • 13
  • [ 81038-35-9 ]
  • [ 89434-03-7 ]
YieldReaction ConditionsOperation in experiment
22% Example 3(a) 4-Fluoroindole-3-acetic acid (SR039) Brownish-white prisms, yield 22%, m.p. 129-131C (lit. 128-129C); m/z: 193 (M+), 14.8 (M+ - CO2H); δH/ppm (CD3COCD3): 7.23-6.49 (4H, m, ArH), 3.85 (2H, s, ArCH2); found C: 61.87%, H: 4.19%, N: 7.12% (calculated C: 62.18%, H: 4.17%, N: 7.25%).
22% Example 3(a) 4-Fluoroindole-3-acetic acid (SR039) Brownish-white prisms, yield 22%, m.p. 129-131 C. (lit. 128-129 C.); m/z: 193 (M+), 148 (M+-CO2H); δH/ppm (CD3COCD3): 7.23-6.49 (4H, m, ArH), 3.85 (2H, s, ArCH2); found C, 61.87%, H, 4.19%, N, 7.12% (calculated C, 62.18%, H, 4.17%, N: 7.25%).
22% Example 3(a) 4-Fluoroindole-3-acetic acid (SR039) Brownish-white prisms, yield 22%, m.p. 129-131 C. (lit. 128-129 C.); m/z: 193 (M+), 148 (M+-CO2H); δH/ppm (CD3COCD3): 7.23-6.49 (4H, m, ArH), 3.85 (2H, s, ArCH2); found C: 61.87%, H: 4.19%, N: 7.12% (calculated C: 62.18%, H: 4.17%, N: 7.25%).
  • 15
  • 1,3-diacetyl-4-fluoroindole [ No CAS ]
  • [ 89434-03-7 ]
YieldReaction ConditionsOperation in experiment
79.5% To a dry three-necked flask was added 6.8 kg of 4-fluoroindole, 30.7 kg of aluminum trichloride, 50.0 L of dichloromethane, 7.9 kg of acetyl chloride was slowly added dropwise to a three-necked flask and heated to 40 C for 8 h. The mixture was poured into 80.0 L of ice water and the organic phase was separated and the solvent was recovered to give 1,3-diacetyl-4-fluoroindole. 16 lkg of morpholine and 4.0 kg of sulfur were added directly and heated to 120 C 8h. After the rearrangement reaction was completed, 50.0 L of methanol was added, dissolved by heating, decolorized by activated charcoal, filtered, cooled,30.0 L of 70% ethanol and 20.0 L of 15% sodium hydroxide solution was added and the mixture was heated under reflux for 4 h. Reaction completed, filtration, vacuum recovery solvent, add appropriate amount of water, diluted with dilute hydrochloric acid ρH- = 1 ~ 2, precipitation of solid. And the mixture was washed with water to neutral to recrystallize with 60% ethanol to give 7.7 kg of 4-fluoroindole-3-acetic acid in 79.5% yield
  • 16
  • [ 13154-24-0 ]
  • [ 89434-03-7 ]
  • C19H28FNO2Si [ No CAS ]
  • 17
  • [ 89434-03-7 ]
  • 3a,4-difluoro-1-(phenylsulfonyl)-8-(triisopropylsilyl)-3,3a,8,8a-tetrahydropyrrolo[2,3-b]indol-2(1H)-one [ No CAS ]
  • (3aR,8aS)-3a,4-difluoro-1-(phenylsulfonyl)-8-(triisopropylsilyl)-3,3a,8,8a-tetrahydropyrrolo[2,3-b]indol-2(1H)-one [ No CAS ]
Historical Records

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