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Chemical Structure| 897446-13-8 Chemical Structure| 897446-13-8

Structure of 897446-13-8

Chemical Structure| 897446-13-8

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Product Details of [ 897446-13-8 ]

CAS No. :897446-13-8
Formula : C13H17NO3
M.W : 235.28
SMILES Code : O=C(C(C1=CC=CC=C1)N2CCC(CC2)O)O
MDL No. :N/A

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Application In Synthesis of [ 897446-13-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 897446-13-8 ]

[ 897446-13-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 37167-62-7 ]
  • [ 5382-17-2 ]
  • [ 897446-13-8 ]
YieldReaction ConditionsOperation in experiment
96% Synthesis of 2-(4-hydroxypiperidin-l-yl)-2-phenylacetic acid4-Hydroxypiperidine * HCl (1.04 g, 7.5 mmol) was dissolved in THF (5 mL) and cooled to 0 °C. Na2C03 (1.59 g, 15 mmol) was added, followed by the dropwise addition of (methyl-a- bromophenylacetate (1.15 g, 5 mmol), and then the reaction mixture was warmed to 25 °C. The mixture was stirred at 25 °C overnight. Completion of the reaction was monitored by LC-MS. Saturated aqueous sodium bicarbonate (20 mL) was then added, and the reaction was extracted three times with EtOAc (15 mL). The reaction was dried with MgSCu, filtered, and dried under reduced pressure. The residue was dissolved in 0.5 mL of MeOH and 1M NaOH (4 mL) was added. The mixture was stirred at 25 °C for 16 hours, at which time it was acidified using 1M HCl. Mixture was extracted with EtOAc and dried with MgS04, and then by reduced pressure to give the title compound: clear oil 1.13 g, 96percent). MS ESI [M + H]+ 236.0, calcd for [C13H17NO3 + H]+ 236.1
 

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