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8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline
Inhibitors/Agonists
Anti-infection
Antiparasitic

[ CAS No. 90-34-6 ]

{[proInfo.proName]} (Synonyms:SN 13272) ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 90-34-6
Chemical Structure| 90-34-6
Structure of 90-34-6 * Storage: {[proInfo.prStorage]}

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* Storage: {[proInfo.prStorage]}

For Research Only 88K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 90-34-6 ]

COA NMR CNMR HPLC LC-MS

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SDS
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Alternatived Products of [ 90-34-6 ]

Product Details of [ 90-34-6 ]

CAS No. :90-34-6 MDL No. :MFCD00598906
Formula : C15H21N3O Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :259.35 g/mol Pubchem ID :4908
Synonyms :

1. Primaquine

Safety of [ 90-34-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 90-34-6 ]

  • Upstream synthesis route of [ 90-34-6 ]
  • Downstream synthetic route of [ 90-34-6 ]

[ 90-34-6 ] Synthesis Path-Upstream   1~18

  • 1
  • [ 63-45-6 ]
  • [ 90-34-6 ]
YieldReaction ConditionsOperation in experiment
86% With sodium hydroxide In water at 20℃; for 2 h; Darkness Primaquine diphosphate (4 mmol) was dissolved in the minimum of distilled water with constant magnetic stirring. Covered with aluminum foil, was added slowly an aqueous solution of 10percent sodium hydroxide until the reaction medium reached the pH = 10. Reaction was left under stirring and shielding the light at room temperature for 2hours. The mixture was extracted with dichloromethane, dried over anhydrous sodium sulphate to give brown oil. Yield: 86percent. GC/MS (m/z): 259.1 (19percent); 201.1 (100percent); 186.0(21percent); 176.0 (26percent); 175.0 (26percent). 1H NMR (400 MHz, MeOD, δ in ppm): 1.28 (3H, d, CHCH3);1.67 (4H, m, CH2CH2); 2.73 (2H, m, CH2NH2);3.65 (1H, m, CHCH3); 3.85 (3H, s, OMe); 6.31 (1H, d, J = 2.4 Hz, H7); 6.44 (1H, d, J = 2.4 Hz, H5); 7.34 (1H, dd, J = 4.2; 8.3 Hz, H3); 8.01 (1H, dd, J = 1.6; 8.3 Hz, H4); 8.48 (1H, dd, J = 1.6; 4.2 Hz, H2). IR (KBr, cm-1):3383; 2943; 2872; 1749; 1616; 1595; 1577; 1519; 1454; 1386; 1219; 1161; 1097;1051; 1016; 925; 875; 8 23.
Reference： [1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 8, p. 1881 - 1884
[2] Arzneimittel-Forschung/Drug Research, 2010, vol. 60, # 10, p. 627 - 635
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 24, p. 6914 - 6917
[4] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 886 - 892
[5] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 886 - 892
[6] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 886 - 892
[7] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 886 - 892
[8] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 886 - 892
[9] ChemMedChem, 2015, vol. 10, # 5, p. 883 - 890
  • 2
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Reference： [1] Patent: US2014/100178, 2014, A1, . Location in patent: Page/Page column
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Reference： [1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 886 - 892
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Reference： [1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 886 - 892
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Reference： [1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 886 - 892
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Reference： [1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 886 - 892
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Reference： [1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 886 - 892
  • 8
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Reference： [1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 886 - 892
  • 9
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Reference： [1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 886 - 892
  • 10
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Reference： [1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 886 - 892
  • 11
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Reference： [1] Chemical Biology and Drug Design, 2017, vol. 90, # 2, p. 254 - 261
  • 12
  • [ 85-81-4 ]
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Reference： [1] Chemical Biology and Drug Design, 2017, vol. 90, # 2, p. 254 - 261
  • 13
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Reference： [1] Chemical Biology and Drug Design, 2017, vol. 90, # 2, p. 254 - 261
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Reference： [1] Chemical Biology and Drug Design, 2017, vol. 90, # 2, p. 254 - 261
  • 15
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  • [ 737004-40-9 ]
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Reference： [1] Journal of Pharmaceutical Sciences, 1995, vol. 84, # 2, p. 256 - 262
  • 16
  • [ 158306-41-3 ]
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Reference： [1] Journal of Pharmaceutical Sciences, 1995, vol. 84, # 2, p. 256 - 262
  • 17
  • [ 80061-32-1 ]
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  • [ 737004-40-9 ]
  • [ 108520-89-4 ]
  • [ 76542-77-3 ]
Reference： [1] Journal of Pharmaceutical Sciences, 1995, vol. 84, # 2, p. 256 - 262
  • 18
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  • [ 63-45-6 ]
Reference： [1] Chemical Biology and Drug Design, 2017, vol. 90, # 2, p. 254 - 261

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[ 90-34-6 ]

Chemical Structure| 63-45-6

A273278[ 63-45-6 ]

N4-(6-Methoxyquinolin-8-yl)pentane-1,4-diamine bis(phosphate)

Reason: Free-salt