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[ CAS No. 90562-34-8 ]

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2D
Chemical Structure| 90562-34-8
Chemical Structure| 90562-34-8
Structure of 90562-34-8 *Storage: {[proInfo.prStorage]}

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Product Details of [ 90562-34-8 ]

CAS No. :90562-34-8MDL No. :MFCD08061330
Formula : C9H11Cl2N Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :204.10Pubchem ID :44784833
Synonyms :

Computed Properties of [ 90562-34-8 ]

TPSA : 12 H-Bond Acceptor Count : 1
XLogP3 : - H-Bond Donor Count : 2
SP3 : 0.33 Rotatable Bond Count : 0

Safety of [ 90562-34-8 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 90562-34-8 ]

  • Downstream synthetic route of [ 90562-34-8 ]

[ 90562-34-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 108464-34-2 ]
  • [ 90562-34-8 ]
  • [ 1224638-41-8 ]
YieldReaction ConditionsOperation in experiment
10% With triethylamine; HATU; In N,N-dimethyl-formamide; at 110.0℃; for 0.5h;Microwave irradiation; Example 33 (7-Chloro-3,4-dihydro-2H-quinolin-1-yl)-[2-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone To a solution of 2-(2,5-dichloro-phenoxy)-nicotinic acid (42.6 mg, 0.15 mmol, 1.0 equiv; Example 31, Step 1) in anhydrous DMF (1.5 mL) was added <strong>[90562-34-8]7-chloro-1,2,3,4-tetrahydro-quinoline hydrochloride</strong> (33.7 mg, 0.17 mmol, 1.1 equiv; [CAS RN 90562-34-8]), triethylamine (30.4 mg, 42 muL, 0.3 mmol, 2.0 equiv; [CAS RN 121-44-8]) and HATU (62.7 mg, 0.17 mmol, 1.1 equiv; [CAS RN 148893-10-1]). The reaction mixture was heated by microwave irradiation to 110 C. for 30 min. Removal of the solvent mixture under reduced pressure and purification by preparative HPLC on reversed phase (Xterra PrepMSC 18, 5 mum, 19*50 mm column equipped with a Gilson Liquid Handler 215 autosampler, two Rainin Dynamax SD-300 pumps, a Sedex ELSD 75 lightscatter and a Dionex UVD 340S UV detector) eluding with a gradient of acetonitrile/water provided 6 mg (10%) of the title compound. MS (ISP): 435.0 [M+H]+.
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