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Chemical Structure| 905831-26-7 Chemical Structure| 905831-26-7

Structure of 905831-26-7

Chemical Structure| 905831-26-7

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Product Details of [ 905831-26-7 ]

CAS No. :905831-26-7
Formula : C10H20N2O3
M.W : 216.28
SMILES Code : O=C(NCC(C)(C(N)=O)C)OC(C)(C)C
MDL No. :MFCD24445637

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Application In Synthesis of [ 905831-26-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 905831-26-7 ]

[ 905831-26-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 180181-02-6 ]
  • [ 905831-26-7 ]
YieldReaction ConditionsOperation in experiment
71% TEA (5.73 ml, 41 .08 mmol) was added to an ice-cooled (0C) solution of 3-[(tert-butoxy)carbonyl]amino}- 2,2-dimethylpropanoic acid (361 ) (5.25 g , 24.16 mmol) in THF (50 ml). The reaction was stirred for 20 min, before the addition of 2-methylpropyl carbonochloridate (4.7 ml, 36.3 mmol) dropwise at 0C. The reaction was stirred for 1 h before the dropwise addition of 35% NH3 (aqueous solution) (7.48 ml, 135.31 mmol).The reaction mixture was warmed to room temperature and stirred for22 h. Saturated NaHC03 (100 ml) was added and the aqueous layer extracted with DCM (3 x 150 ml). The combined organic layers were dried (MgSC), filtered and evaporated to give an off-white semi-solid (6.61 g). Purification by flash column chromatography (eluting with a gradient of 0-10% MeOH / DCM) gave the title compound (3.7 g, 71 %) as a white solid . 1 H-NMR (CDCI3, 250 MHz): d[ppm]= 5.95 (s, 1 H), 5.30 (s, 1 H), 5.08 (s, 1 H), 3.25 (d , J = 6.6 Hz, 2H), 1 .43 (s, 9H), 1 .21 (s, 6H) HPLCMS (Method A): [m/z]: 239.10 [M+Na]+
 

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