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[ CAS No. 909389-74-8 ]

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Chemical Structure| 909389-74-8
Chemical Structure| 909389-74-8
Structure of 909389-74-8 * Storage: {[proInfo.prStorage]}

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Product Details of [ 909389-74-8 ]

CAS No. :909389-74-8 MDL No. :MFCD08445663
Formula : C8H6Br2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :293.94 g/mol Pubchem ID :-
Synonyms :

Safety of [ 909389-74-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 909389-74-8 ]

  • Downstream synthetic route of [ 909389-74-8 ]

[ 909389-74-8 ] Synthesis Path-Downstream   1~16

  • 1
  • [ 909389-74-8 ]
  • 4-ethynylpyridine hydrochloride [ No CAS ]
  • [ 909389-75-9 ]
YieldReaction ConditionsOperation in experiment
66% With triethylamine In tetrahydrofuran at 60℃; for 16h;
66% With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine In tetrahydrofuran at 60℃; for 16h;
65.3% With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine In tetrahydrofuran at 60℃;
  • 3
  • [ 909389-74-8 ]
  • [ 909389-76-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 66 percent / Pd(PPh3)4; CuI; Et3N / tetrahydrofuran / 16 h / 60 °C 2: 99 percent / aq. NaHCO3 / methanol / 2 h / 20 °C
Multi-step reaction with 2 steps 1: 66 percent / Et3N / Pd(PPh3)4; CuI / tetrahydrofuran / 16 h / 60 °C 2: 95 percent / aq. NaHCO3 / methanol / 2 h / 20 °C
  • 4
  • [ 909389-74-8 ]
  • [ 909389-77-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: 66 percent / Pd(PPh3)4; CuI; Et3N / tetrahydrofuran / 16 h / 60 °C 2.1: 99 percent / aq. NaHCO3 / methanol / 2 h / 20 °C 3.1: NaH / dimethylformamide / 0.5 h 3.2: 85 percent / dimethylformamide / 2 h / 65 °C
  • 5
  • [ 909389-74-8 ]
  • [ 909389-78-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: 66 percent / Pd(PPh3)4; CuI; Et3N / tetrahydrofuran / 16 h / 60 °C 2.1: 99 percent / aq. NaHCO3 / methanol / 2 h / 20 °C 3.1: NaH / dimethylformamide / 0.5 h 3.2: 89 percent / dimethylformamide / 2 h / 65 °C
  • 6
  • [ 909389-74-8 ]
  • [ 909389-79-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: 66 percent / Pd(PPh3)4; CuI; Et3N / tetrahydrofuran / 16 h / 60 °C 2.1: 99 percent / aq. NaHCO3 / methanol / 2 h / 20 °C 3.1: NaH / dimethylformamide / 0.5 h 3.2: 87 percent / dimethylformamide / 2 h / 65 °C
  • 7
  • [ 909389-74-8 ]
  • C28H20N2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 66 percent / Et3N / Pd(PPh3)4; CuI / tetrahydrofuran / 16 h / 60 °C 2: 95 percent / aq. NaHCO3 / methanol / 2 h / 20 °C 3: 85 percent / NaH / dimethylformamide / 65 °C
  • 8
  • [ 909389-74-8 ]
  • C42H32N2O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 66 percent / Et3N / Pd(PPh3)4; CuI / tetrahydrofuran / 16 h / 60 °C 2: 95 percent / aq. NaHCO3 / methanol / 2 h / 20 °C 3: 89 percent / NaH / dimethylformamide / 65 °C
  • 9
  • [ 909389-74-8 ]
  • C70H56N2O7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 66 percent / Et3N / Pd(PPh3)4; CuI / tetrahydrofuran / 16 h / 60 °C 2: 95 percent / aq. NaHCO3 / methanol / 2 h / 20 °C 3: 87 percent / NaH / dimethylformamide / 65 °C
  • 10
  • [ 909389-74-8 ]
  • [ 1066-54-2 ]
  • [ 1020182-87-9 ]
YieldReaction ConditionsOperation in experiment
86% With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine In toluene at 110℃; for 0.5h; Microwave irradiation; Inert atmosphere;
80% With triethylamine In tetrahydrofuran at 20℃; for 16h;
  • 11
  • [ 626-41-5 ]
  • [ 75-36-5 ]
  • [ 909389-74-8 ]
YieldReaction ConditionsOperation in experiment
92% With pyridine; In dichloromethane; at 0 - 20℃;Inert atmosphere; To a stirred solution of compound XLVIII-1 (10.00 g, 39.69 mmol) in DCM (20 mL) and Py (50 mL) was added dropwise acetyl chloride (3.73 g, 47.51 mmol) at 0 °C under argon. After the addition, the solution was stirred overnight at room temperature. TLC monitored the reaction. After completion of the reaction, the mixture was poured into ice/water (100 mL), extract with DCM (50 mL x 3), the combined organic layers were dried over Na2S04, concentrated in vacuo. The residue was purified by column chromatography (PE:EA = 100: 1) to afford compound XLVIII-2 (11.67 g , yield: 92percent).
  • 12
  • [ 909389-74-8 ]
  • [ 669767-20-8 ]
YieldReaction ConditionsOperation in experiment
81.25% With aluminum (III) chloride at 160℃; for 3h; Inert atmosphere; XLVIII A stirred solution of compound XLVIII-2 (8.00 g, 54.43 mmol) and A1C13 (7.26 g, 54.43 mmol) was heated to 160 °C for 3 hours under argon. The solution was quenched with water, extract with EtOAc (60 mL x 3), the combined organic layers were dried over Na2S04, concentrated in vacuo, and purified by chromatography (PE:EA = 50: 1) to afford compound XLVIII-3 (6.5 g, yield 81.25%). 1H NMR (400MHz, DMSO-d6) ^10.94 (s, 1 H), 7.32 (s, 1H), 7.07 (s, 1 H), 2.43 (s, 3 H).
  • 13
  • [ 909389-74-8 ]
  • [ 1423702-17-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: aluminum (III) chloride / 3 h / 160 °C / Inert atmosphere 2: sodium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
  • 14
  • [ 909389-74-8 ]
  • [ 1423702-20-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: aluminum (III) chloride / 3 h / 160 °C / Inert atmosphere 2: sodium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 3: pyridine; hydroxylamine hydrochloride / 6 h / 130 °C / Inert atmosphere
  • 15
  • [ 909389-74-8 ]
  • [ 1423702-22-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: aluminum (III) chloride / 3 h / 160 °C / Inert atmosphere 2: sodium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 3: pyridine; hydroxylamine hydrochloride / 6 h / 130 °C / Inert atmosphere 4: N,N`-dimethylethylenediamine; sodium t-butanolate; copper(l) iodide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
  • 16
  • [ 909389-74-8 ]
  • [ 1423702-25-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: aluminum (III) chloride / 3 h / 160 °C / Inert atmosphere 2: sodium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 3: pyridine; hydroxylamine hydrochloride / 6 h / 130 °C / Inert atmosphere 4: N,N`-dimethylethylenediamine; sodium t-butanolate; copper(l) iodide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 5: boron tribromide / dichloromethane / 0 °C / Inert atmosphere
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