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Chemical Structure| 912287-56-0 Chemical Structure| 912287-56-0

Structure of YHO-13177
CAS No.: 912287-56-0

Chemical Structure| 912287-56-0

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YHO-13177 is a selective and potent inhibitor of BCRP, it potentiates the cytotoxicity of SN-38 in cancer cells and has no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.

Synonyms: YHO-13177

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Product Details of YHO-13177

CAS No. :912287-56-0
Formula : C20H22N2O3S
M.W : 370.47
SMILES Code : N#C/C(C1=CC=C(OC)C(OC)=C1)=C\C2=CC=C(N3CCC(O)CC3)S2
Synonyms :
YHO-13177
MDL No. :MFCD28900680
InChI Key :NOGGBVNCVONHHC-RVDMUPIBSA-N
Pubchem ID :16757522

Safety of YHO-13177

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P280

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Mouse small intestinal 3D organoids 20 μM 20, 40, 60, 80, 100 minutes To verify the inhibitory effect of YHO-13177 on BCRP-mediated Hoechst 33342 transport, results showed that YHO-13177 significantly inhibited BCRP-mediated Hoechst 33342 transport PMC8241135

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.70mL

0.54mL

0.27mL

13.50mL

2.70mL

1.35mL

26.99mL

5.40mL

2.70mL

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