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[ CAS No. 913835-73-1 ]

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Chemical Structure| 913835-73-1
Chemical Structure| 913835-73-1
Structure of 913835-73-1 * Storage: {[proInfo.prStorage]}

Quality Control of [ 913835-73-1 ]

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Product Details of [ 913835-73-1 ]

CAS No. :913835-73-1 MDL No. :MFCD08689487
Formula : C7H6BBrO4 Boiling Point : 480.728°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :244.84 g/mol Pubchem ID :-
Synonyms :

Safety of [ 913835-73-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 913835-73-1 ]

  • Downstream synthetic route of [ 913835-73-1 ]

[ 913835-73-1 ] Synthesis Path-Downstream   1~16

  • 1
  • [ 626-39-1 ]
  • [ 124-38-9 ]
  • [ 913835-73-1 ]
YieldReaction ConditionsOperation in experiment
82% Stage #1: 1,3,5-trisbromobenzene With n-butyllithium In diethyl ether; hexane at -80℃; for 0.5h; Inert atmosphere; Stage #2: With Triisopropyl borate In tetrahydrofuran; diethyl ether; hexane at -70℃; for 0.5h; Inert atmosphere; Stage #3: carbon dioxide Further stages;
  • 2
  • [ 913835-73-1 ]
  • [ 1025718-78-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C
  • 3
  • [ 913835-73-1 ]
  • (3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C
  • 4
  • [ 913835-73-1 ]
  • ((3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)(tert-butyl)dimethylsilane [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C
  • 5
  • [ 913835-73-1 ]
  • (2S,3R)-tert-butyl 3-(3-bromo-5-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-oxopyrrolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C 5: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
  • 6
  • [ 913835-73-1 ]
  • (2S,3R)-tert-butyl 3-(3-bromo-5-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-2-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C 5: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere 6: boron trichloride methyl sulfide complex / tetrahydrofuran / 2 h / Reflux
  • 7
  • [ 913835-73-1 ]
  • (2S,3R)-tert-butyl 3-(3-bromo-5-(hydroxymethyl)phenyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C 5: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere 6: boron trichloride methyl sulfide complex / tetrahydrofuran / 2 h / Reflux 7: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 °C
  • 8
  • [ 913835-73-1 ]
  • (2S,3R)-tert-butyl-2-(hydroxymethyl)-3-(3-(hydroxymethyl)-5-(pyridin-2-yl)phenyl)pyrrolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C 5: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere 6: boron trichloride methyl sulfide complex / tetrahydrofuran / 2 h / Reflux 7: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 °C 8: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium phosphate / 1,4-dioxane / 20 h / 50 °C / Inert atmosphere
  • 9
  • [ 913835-73-1 ]
  • (2S,3R)-tert-butyl-2-(hydroxymethyl)-3-(3-(hydroxymethyl)-5-(pyridin-3-yl)phenyl)pyrrolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C 5: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere 6: boron trichloride methyl sulfide complex / tetrahydrofuran / 2 h / Reflux 7: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 °C 8: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 5.5 h / 90 °C / Inert atmosphere
  • 10
  • [ 913835-73-1 ]
  • (2S,3R)-tert-butyl-2-(hydroxymethyl)-3-(3-(hydroxymethyl)-5-(pyridin-4-yl)phenyl)pyrrolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C 5: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere 6: boron trichloride methyl sulfide complex / tetrahydrofuran / 2 h / Reflux 7: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 °C 8: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 5.5 h / 90 °C / Inert atmosphere
  • 11
  • [ 913835-73-1 ]
  • (2S,3R)-tert-butyl-2-(hydroxymethyl)-3-(3-(hydroxymethyl)-5-(pyrimidin-5-yl)phenyl)pyrrolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C 5: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere 6: boron trichloride methyl sulfide complex / tetrahydrofuran / 2 h / Reflux 7: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 °C 8: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 4 h / 95 °C / Inert atmosphere; Sealed tube
  • 12
  • [ 913835-73-1 ]
  • C21H27N3O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C 5: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere 6: boron trichloride methyl sulfide complex / tetrahydrofuran / 2 h / Reflux 7: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 °C 8: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 4 h / 95 °C / Inert atmosphere; Sealed tube
  • 13
  • [ 913835-73-1 ]
  • (2S,3R)-1-(tert-butoxycarbonyl)-3-(3-carboxy-5-(pyridin-2-yl)phenyl)pyrrolidine-2-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 9 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C 5: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere 6: boron trichloride methyl sulfide complex / tetrahydrofuran / 2 h / Reflux 7: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 °C 8: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium phosphate / 1,4-dioxane / 20 h / 50 °C / Inert atmosphere 9: sodium periodate; ruthenium(III) trichloride hydrate / ethyl acetate; acetonitrile / 2 h / 0 °C
  • 14
  • [ 913835-73-1 ]
  • (2S,3R)-1-(tert-butoxycarbonyl)-3-(3-carboxy-5-(pyridin-3-yl)phenyl)pyrrolidine-2-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 9 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C 5: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere 6: boron trichloride methyl sulfide complex / tetrahydrofuran / 2 h / Reflux 7: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 °C 8: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 5.5 h / 90 °C / Inert atmosphere 9: sodium periodate; ruthenium(III) trichloride hydrate / ethyl acetate; acetonitrile; water / 2 h / 0 °C
  • 15
  • [ 913835-73-1 ]
  • (2S,3R)-1-(tert-butoxycarbonyl)-3-(3-carboxy-5-(pyridin-4-yl)phenyl)pyrrolidine-2-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 9 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C 5: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere 6: boron trichloride methyl sulfide complex / tetrahydrofuran / 2 h / Reflux 7: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 °C 8: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 5.5 h / 90 °C / Inert atmosphere 9: sodium periodate; ruthenium(III) trichloride hydrate / ethyl acetate; acetonitrile; water / 2 h / 0 °C
  • 16
  • [ 913835-73-1 ]
  • (2S,3R)-1-(tert-butoxycarbonyl)-3-(3-carboxy-5-(pyrimidin-5-yl)phenyl)pyrrolidine-2-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 9 steps 1: sulfuric acid / 20 h / Reflux 2: diethyl ether / 1.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C 5: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere 6: boron trichloride methyl sulfide complex / tetrahydrofuran / 2 h / Reflux 7: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 °C 8: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 4 h / 95 °C / Inert atmosphere; Sealed tube 9: sodium periodate; ruthenium(III) trichloride hydrate / ethyl acetate; acetonitrile; water / 2 h / 0 °C
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