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[ CAS No. 924632-90-6 ] {[proInfo.proName]}

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Chemical Structure| 924632-90-6
Chemical Structure| 924632-90-6
Structure of 924632-90-6 * Storage: {[proInfo.prStorage]}
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Product Details of [ 924632-90-6 ]

CAS No. :924632-90-6 MDL No. :
Formula : C17H13Br2NO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 407.11 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 924632-90-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 924632-90-6 ]

[ 924632-90-6 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 924632-90-6 ]
  • [ 52605-49-9 ]
  • C22H23BrN2O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
100% With potassium carbonate; In acetonitrile; at 80℃; for 18h; Example B2; a) Preparation of compound 131; A mixture of intermediate 7 (prepared according to A2.d) (0.24 mmol), <strong>[52605-49-9]sarcosine ethyl ester hydrochloride</strong> (0.24 mmol) and K2CO3 (0.24 mmol) in CH3CN (5 ml) was stirred at 80C for 18 hours. The mixture was cooled and poured into water and extracted with CH2Cl2. The organic layer was dried over MgSO4, filtered, and the solvent was evaporated. The residue was crystallized from diisopropyl ether. The precipitate was filtered off and dried. Yield: final compound 137 (100 %).
  • 2
  • [ 924632-90-6 ]
  • [ 3034-38-6 ]
  • [ 1159275-28-1 ]
  • 3
  • [ 924632-90-6 ]
  • [ 63989-79-7 ]
  • [ 1159275-30-5 ]
YieldReaction ConditionsOperation in experiment
42% With sodium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 110℃; for 14h;
12% With tetrabutylammomium bromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene for 12h; Heating / reflux; 4 EXAMPLE 4; Preparation of(+/-)-6-[(6-Bromo-2-methoxy-quinolin-3-yl)-phenyl-methyl]-amino}-chromen-2-one; A mixture of (+/-)-6-Bromo-3- (bromophenyl methyl) -2 -methoxy-qumoline (020 g, 0 49 mmol), 6- ammocoumarm hydrochloride (0 09 g, 0 5 mmol), l,8-diazabicyclo-[5 4 0]undec-7-ene (007 ml, 0 5 mmol), tetrabutylammonmm bromide (003 g, 0 09 mmol) and potassium carbonate in toluene were heated under reflux for 12 h The reaction mixture was cooled to room temperature, poured into water, diluted with ethyl acetate and the organic layer was separated The organic layer was washed with water followed by brme, dried oveτ anhydrous sodium sulfate, filtered and concentrated under vacuum The crude product was purified by column chromatography on silica gel ( 100-200 mesh) eluting with hexane - ethyl acetate (9 1, v/v) to afford the compound (+/-)-6-[(6-Bromo-2-methoxy-qumolin-3-yl)-phenyl- methyl]-ammo}-chromen-2-one (0 03 g, 12%) as a pale yellow solid, Mp 88-89 T 1H NMR (400 MHz, CDCl3) δ 4 02 (s, 3 H), 4 33 (d, J= 3 6 Hz, 1 H), 5 77 (d, J= 3 7 Hz, 1 H), 6 32 (d, J= 9 5 Hz, 1 H), 6 44 (d J = 1 8 Hz, 1 H), 6 80 (dd, J= 9 0, 2 8 Hz, 1 H), 7 13 (d J= 8 8 Hz, 1 H), 7 29-7 34 (m 5 H), 7 50 (d, J= 5 6 Hz, 1 H), 7 65 (dd, J = 9 0, 2 4 Hz, 1 H), 7 70 (d, J = 8 8 Hz, 1 H), 7 82 (d, J = 1 6 Hz, 1 H), 7 98 (s, 1 H) [M+H]+ = 486, 488
  • 4
  • [ 924632-90-6 ]
  • [ 1202-00-2 ]
  • N-((6-bromo-2-methoxyquinolin-3-yl) (phenyl)methyl)-2-(2-(dimethylamino)ethoxy)aniline [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate In N,N-dimethyl-formamide
  • 5
  • [ 316146-27-7 ]
  • [ 924632-90-6 ]
  • 6
  • [ 654655-68-2 ]
  • [ 924632-90-6 ]
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