Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

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CAS No. :	929016-96-6
Formula :	C₂₀H₃₀N₄O₂
M.W :	358.48
SMILES Code :	O=C(NO)/C=C/C1=CC=C2C(N=C(CCCC)N2CCN(CC)CC)=C1
Synonyms :	SB939
MDL No. :	MFCD17215206
InChI Key :	JHDKZFFAIZKUCU-ZRDIBKRKSA-N
Pubchem ID :	49855250

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H315-H319-H228
Precautionary Statements:	P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313
Class:	4.1
UN#:	1325
Packing Group:	Ⅱ

FaDu cells	0.2 µM	15 days	Suppressed 3D spheroid growth of FaDu cells, significantly reducing spheroid volume when combined with X-ray irradiation	PMC11640432
LU505 cells	125nM	21 days	Pracinostat treatment resulted in increased E-CADHERIN expression and global H3K27Ac levels.	PMC6294438
32D murine myeloid cells	125-500 nM	24 hours	Pracinostat treatment decreased both pJAK2 (Y1007/08) and pSTAT5 (Y694) levels, and also total JAK2 and STAT5 protein in JAK2V617F mutant cells.	PMC3366067
HEL92.1.7 and SET-2 cells	125-500 nM	24 hours	Pracinostat treatment decreased both pJAK2 (Y1007/08) and pSTAT5 (Y694) levels, and also total JAK2 and STAT5 protein in JAK2V617F mutant cells.	PMC3366067
MV4-11 and MOLM-13 cells	500 nM	24 hours	Pracinostat treatment nearly completely ablated pFLT3 (Y591), accompanied by a decrease in total FLT3 and pSTAT5.	PMC3366067
HCT116	1 μM	24 hours	Pracinostat significantly induced mitochondrial fragmentation in CRC cells, as evidenced by the elevated number of fragmented mitochondria, the decrease in tubular mitochondria and the ratio of rod/branch length.	PMC10657975
HT29	0–2 μM	24 hours	Pracinostat increased the number of fragmented mitochondria.	PMC10657975
HEK293 cells	1 µM	48 hours	Confirming the effect of Pracinostat on BDNF mRNA expression, it was shown to significantly increase BDNF mRNA levels	PMC6429164
DLBCL cells	250 nM	6 hours or 72 hours	To evaluate the antiproliferative activity of Pracinostat on DLBCL cells, the results showed that Pracinostat exhibited robust activity across all lymphoma histotypes.	PMC8152508
FaDu cells	1 µM	7-14 days	Enhanced radiosensitivity of FaDu cells, significantly inhibiting clonogenic survival	PMC11640432
A253 cells	1 µM	7-14 days	Enhanced radiosensitivity of A253 cells, significantly inhibiting clonogenic survival	PMC11640432
UMSCC11b cells	1 µM	7-14 days	Enhanced radiosensitivity of UMSCC11b cells, significantly inhibiting clonogenic survival	PMC11640432
NCI-H1299	500 nM	72 hours	To evaluate the effect of Pracinostat on NCI-H1299 cells, results showed that Pracinostat induced transcription of non-annotated transcription start sites (TINATs).	PMC6005702
BCR-DLBCL and OxPhos-DLBCL cells	250 nM	72 hours	To evaluate the apoptosis induction effect of Pracinostat on BCR-DLBCL and OxPhos-DLBCL cells, the results showed marked apoptosis induction in BCR-DLBCLs, while the percentage of apoptotic cells in OxPhos-DLBCLs was lower.	PMC8152508
AML cells	100 nM	96 hours	To evaluate the effect of Pracinostat on the growth of AML cells, results showed that Pracinostat inhibited the growth of AML cells	PMC8941473
Human Neural Progenitor Cells (HNPCs)	1 µM		Screening for small compounds capable of modulating BDNF expression, Pracinostat was found to have a significant impact on BDNF expression	PMC6429164

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CAS No.: 929016-96-6

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CAS No.: 929016-96-6

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Mice	AML model		50 nM	Not specified	To evaluate the effect of Pracinostat on AML model mice, results showed that Pracinostat significantly suppressed the growth of AML cells	PMC8941473
Mice	Neuroblastoma xenograft model	Intraperitoneal injection	150 mg/kg	Once daily for 5 days	To evaluate the effect of Pracinostat on the neuroblastoma xenograft model, results showed that Pracinostat significantly increased transcription of LTR12C.	PMC6005702
Mice	Rb1/Trp53/Crebbp-deficient SCLC model	Oral	100mg/kg	Daily, 5 days per week for 3 weeks	To evaluate the efficacy of Pracinostat in the Rb1/Trp53/Crebbp-deficient SCLC model, it was found that Pracinostat treatment significantly inhibited tumor growth, with some mice showing complete regression.	PMC6294438
BALB/c nude mice	MV4-11 xenograft model	Oral	25 or 50 mg/kg	Daily for 21 days	Pracinostat significantly inhibited tumor growth (TGI), by 59% and 116%, respectively. Complete tumor regression was observed in 6 out of 10 animals at the end of the treatment after the 50-mg dose.	PMC3366067
BalB/c Nude mice	A549 xenograft model	Intraperitoneal injection	20 mg/kg	Once daily for 21 days	To evaluate the antitumor efficacy of 3b in the A549 xenograft model, showing significant inhibition of tumor growth with negligible effect on mean body weight.	PMC10930102
NOD-SCID mice	DLBCL xenograft model	Oral gavage	100 mg/kg	Once daily, 5 days per week for 11 days	To evaluate the antilymphoma activity of Pracinostat in the DLBCL xenograft model, the results showed that Pracinostat significantly delayed tumor growth in the TMD8 model and remained effective throughout the experiment.	PMC8152508
Nude mice	CRC xenograft model	Oral	25 mg/kg	Every two days	Pracinostat significantly suppressed the growth of CRC tumors with high CDK5 expression.	PMC10657975

NCT01184274	Leukemia\|Solid Tumours	PHASE1	COMPLETED	2014-01-16	Alberta Children's Hospital, C... More >>algary, Alberta, T3B 6A8, Canada\|Stollery Children's Hospital, Edmonton, Alberta, T6G 2B7, Canada\|Children's and Women's Health Centre of BC Branch, Vancouver, British Columbia, V6H 3V4, Canada\|CancerCare Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada\|Izaak Walton Killam (IWK) Health Centre, Halifax, Nova Scotia, B3K 6R8, Canada\|Children's Hospital of Eastern Ontario, Ottawa, Ontario, K1H 8L1, Canada\|Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada\|CHU Sainte-Justine, Montreal, Quebec, H3T 1C5, Canada Less <<
NCT01112384	Metastatic Sarcoma	PHASE2	COMPLETED	2014-01-16	Tom Baker Cancer Centre, Calga... More >>ry, Alberta, T2N 4N2, Canada\|Cross Cancer Institute, Edmonton, Alberta, T6G 1Z2, Canada\|BCCA - Vancouver Cancer Centre, Vancouver, British Columbia, V5Z 4E6, Canada\|Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario, L8V 5C2, Canada\|London Regional Cancer Program, London, Ontario, N6A 4L6, Canada\|Ottawa Health Research Institute - General Division, Ottawa, Ontario, K1H 8L6, Canada\|Univ. Health Network-Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada\|McGill University - Dept. Oncology, Montreal, Quebec, H2W 1S6, Canada Less <<
NCT01200498	Myeloproliferative Disorders	PHASE2	COMPLETED	2025-11-12	UT MD Anderson Cancer Center, ... More >>Houston, Texas, 77030, United States Less <<

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed