[ CAS No. 929252-65-3 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 929252-65-3
Chemical Structure| 929252-65-3
Structure of 929252-65-3

Quality Control of [ 929252-65-3 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 929252-65-3 ]

SDS

Product Details of [ 929252-65-3 ]

CAS No. :929252-65-3MDL No. :MFCD26386170
Formula :C27H32FN3O5Boiling Point :-
Linear Structure Formula :-InChI Key :-
M.W :497.56Pubchem ID :59342474
Synonyms :

Computed Properties of [ 929252-65-3 ]

TPSA : 96.1 H-Bond Acceptor Count : 8
XLogP3 : 4.7 H-Bond Donor Count : 1
SP3 : 0.41 Rotatable Bond Count : 8

Safety of [ 929252-65-3 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 929252-65-3 ]

  • Upstream synthesis route of [ 929252-65-3 ]

[ 929252-65-3 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 849217-45-4 ]
  • [ 929252-65-3 ]
YieldReaction ConditionsOperation in experiment
52% With iron; ammonium chloride In ethanol; water for 2.00 h; Heating / reflux Step 4.
tert-butyl 4-((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yloxy)methyl)piperidine-1-carboxylate (81)
To a solution of compound 80 (0.50 g, 0.95 mmol) in ethanol (8 mL) and water (4 mL) were added iron (0.254 g, 4.55 mmol) and ammonium chloride (0.123 g, 2.26 mmol).
The reaction mixture was heated to reflux for 2 h, diluted with methanol and the solid suspension was filtered off.
The filtrate was concentrated and the residue was purified by Gilson (eluent gradient 35percent to 57percent methanol/dichloromethane) to afford title compound 81 (0.25 g, 52percent yield).
Reference: [1] Patent: US2008/4273, 2008, A1. Location in patent: Page/Page column 79; 80
[2] Patent: US2007/60613, 2007, A1. Location in patent: Page/Page column 17-18
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