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Chemical Structure| 932359-76-7 Chemical Structure| 932359-76-7

Structure of FiVe1
CAS No.: 932359-76-7

Chemical Structure| 932359-76-7

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FiVe1 is an effective vimentin (VIM) inhibitor, where VIM is an intermediate filament and mesenchymal marker. FiVe1 promotes VIM degradation and phosphorylation during metaphase, leading to mitotic abnormalities, multinucleation, and loss of stemness. Additionally, FiVe1 selectively and irreversibly inhibits the proliferation of multiple FOXC2-expressing breast cancer cell lines (IC50: 267 nM for HMLER cells; IC50: 447 nM for FOXC2-HMLER cells) and suppresses the migration of mesenchymal transition cells.

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Product Details of FiVe1

CAS No. :932359-76-7
Formula : C18H16Cl2N4
M.W : 359.25
SMILES Code : ClC1=CC(N2CCN(CC2)C3=C4C=CC=C(C4=NN=C3)Cl)=CC=C1
MDL No. :MFCD14927037

Safety of FiVe1

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

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Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.92mL

2.78mL

1.39mL

27.84mL

5.57mL

2.78mL

 

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