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Chemical Structure| 93635-76-8
Chemical Structure| 93635-76-8
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Product Details of [ 93635-76-8 ]

CAS No. :93635-76-8 MDL No. :MFCD11112138
Formula : C11H20O6 Boiling Point : -
Linear Structure Formula :- InChI Key :BHCHXRCKXIVVCN-XLDPMVHQSA-N
M.W : 248.27 Pubchem ID :52987879
Synonyms :

Calculated chemistry of [ 93635-76-8 ]

Physicochemical Properties

Num. heavy atoms : 17
Num. arom. heavy atoms : 0
Fraction Csp3 : 0.91
Num. rotatable bonds : 5
Num. H-bond acceptors : 6.0
Num. H-bond donors : 2.0
Molar Refractivity : 58.73
TPSA : 85.22 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : Yes
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -8.03 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.48
Log Po/w (XLOGP3) : -0.31
Log Po/w (WLOGP) : -0.19
Log Po/w (MLOGP) : -0.49
Log Po/w (SILICOS-IT) : 0.66
Consensus Log Po/w : 0.43

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -0.85
Solubility : 34.7 mg/ml ; 0.14 mol/l
Class : Very soluble
Log S (Ali) : -1.02
Solubility : 23.8 mg/ml ; 0.0957 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -0.55
Solubility : 70.8 mg/ml ; 0.285 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 4.12

Safety of [ 93635-76-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 93635-76-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 93635-76-8 ]
  • Downstream synthetic route of [ 93635-76-8 ]

[ 93635-76-8 ] Synthesis Path-Upstream   1~7

  • 1
  • [ 130606-67-6 ]
  • [ 93635-76-8 ]
YieldReaction ConditionsOperation in experiment
83% With potassium permanganate; C28H55N2(1+)*Cl(1-) In acetone at 0 - 5℃; for 2.17 h; To a 1000-mL three-necked flask was charged 1t (54.0 g, 0.25 mol) and acetone (500 mL); QAS-2 (11.4 g, 25.0 mmol) was added. The mixture was cooled to 0–5 °C. Solid KMnO4 (47.5 g, 0.3 mol) was added in 10 portions within 10 min. The mixture was stirred at the same temperature for 2 h, and TLC indicated complete consumption of 1t. A solution of NaHSO3 (25.0 g) in water (50 mL) was added in one portion to quench the reaction. The mixture was stirred for 15 min and then filtered on Celite, which was washed thoroughly with acetone (3 × 100 mL). The combined filtrates were concentrated to remove acetone under reduced pressure and the residue was extracted with EtOAc (3 × 150 mL). The combined organic phases were washed with sat. brine (3 × 50 mL), dried (Na2SO4), filtered, and evaporated to dryness to afford a colorless oil (57.5 g, 93 percent), which was recrystallized(petroleum ether, 200 mL) to afford the product as a white solid; yield: 51.3 g (83 percent); mp 75–76 °C. 1H NMR (400 MHz, CDCl3): δ = 4.20–4.31 (m, 3 H), 4.09 (m, 2 H), 3.93 (d, J = 8.0 Hz, 1 H), 2.52 (br, 2 H), 1.31–1.49 (m, 12 H).
80.26% With potassium permanganate In acetone at 0 - 5℃; for 2 h; To a stirred solution of 271-2 (100 g, 0.47 mol) in acetone (2.0 L) was added KMnO4 (90 g, 0.57 mol) in portions at 0-5° C. The mixture was stirred at 0-5° C. for 2 h. The reaction was quenched using sat. sodium sulfite solution (600 mE). Afier 2 h, a colorless suspension was formed. The solid was removed by filtration. The filter cake was washed with EA (300 mE). The filtrate was extracted with EA (3x300 mE). The organic phase was dried over anhydrous Na2SO4. The organic phase was concentrated under reduced pressure to give crude 271-3 (50 g, 43.4percent) as a solid.
65.7% With potassium permanganate; sodium hydrogencarbonate; ethylene glycol In water; acetone at -10℃; for 3 h; Large scale To a stirred solution of Int lc (4.2 kg, 19.63 mol), glycol (4.9 kg, 78.50 mol), NaHC03 (5.0 kg, 58.89 mol) and water (8.4 L) in acetone (44.0 L) was added KMn04 (3.3 kg, 20.61 mol) in portions at - 10° C over 2 hours. The resulting solution was stirred for 1 hour at -10° C in a liquid nitrogen bath. The reaction was then quenched by the addition of NaHS03 solution (6.0 L). The resulting solid was removed by filtration. The filtrate was diluted with H20 (20 L) and extracted with ethyl acetate (4x 3 L). The combined organic layers were dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue obtained was treated with hexanes (20 L) at -10° C. The resulting solid was collected by filtration and dried at 45° C to provide Int Id as a white solid (3.2 kg, 65.7percent).
65.7% With potassium permanganate; sodium hydrogencarbonate; ethylene glycol In water; acetone at -10℃; for 3 h; Large scale To a stirred solution of Int lc (4.2 kg, 19.63 mol), glycol (4.9 kg, 78.50 mol), NaHC03 (5.0 kg, 58.89 mol) and water (8.4 L) in acetone (44.0 L) was added KMn04 (3.3 kg, 20.61 mol) in portions at - 10° C over 2 hours. The resulting solution was stirred for 1 hour at -10° C in a liquid nitrogen bath. The reaction was then quenched by the addition of NaHS03 solution (6.0 L). The resulting solid was removed by filtration. The filtrate was diluted with H20 (20 L) and extracted with ethyl acetate (4x 3 L). The combined organic layers were dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue obtained was treated with hexanes (20 L) at -10° C. The resulting solid was collected by filtration and dried at 45° C to provide Int Id as a white solid (3.2 kg, 65.7percent).
64.1% With sodium permanganate; sodium hydrogencarbonate; ethylene glycol In acetone at -15 - 10℃; for 1.5 h; A mixture of 50 g of compound 3,58.5 g of ethylene glycol,59.5 Sodium bicarbonate solid,750 ml of acetone was cooled to -15 to 10 ° C,Then, 100 g of a 36percent aqueous solution of sodium permanganate was slowly added thereto while maintaining the temperature,The reaction was terminated by adding dropwise for 1.5 hours.After completion of the reaction,Slowly dropping 0 25percent sodium bisulfite solution 75ml,Dropping process system temperature 0 ~ 5 ,After stirring for 30 minutes, 12.5 g of CELITE in 25 ml of acetone was added and stirred for 1 hour. The filter cake was washed with acetone and the filtrate was combined. The acetone was removed by concentration under reduced pressure and extracted with ethyl acetate (250 ml * 3), washed with 250 ml of water The organic phase was distilled at atmospheric pressure and the ethyl acetate was replaced with toluene. The mixture was concentrated to a paste and 250 ml of heptane was added. The mixture was cooled to 25 to 28 ° C and stirred for 2 hours. The mixture was stirred at -10 to -5 ° C for 5 hours, filtered, percent Toluene in heptane and dried in vacuo at 48-50 ° C to give 37.2 g of a white crystalline solid 4 in 64.1percent yield with a purity of 98.9percent.
60% With potassium permanganate; sodium hydrogencarbonate; ethylene glycol In water; acetone at -15 - -10℃; for 2 h; Large scale Step B: Synthesis of 16d A solution of Int-16c (2.6 kg, 12.15 mol, 1.00 eq) in acetone (40 L) was treated with a solution of ethane-1,2-diol (3.0 kg, 12.76 mol, 4.00 eq) and NaHCO3 (3.06 kg, 36.45 mol, 3.00 eq) in H2O (5.2 L). KMnO4 (2.02 kg, 12.76 mol, 1.05 eq) was added in several portions into the above solution while maintaining the temperature at −15° C.−10° C. (about 1 hour to complete addition). The mixture was allowed to react for 1 hour at −15° C.−10° C. until the SM was consumed completely. The resulting solution was quenched with NaHSO3 (aqueous 25percent w/w, 5 L) while maintaining the temperature below 4° C. A filtration was performed and the filter cake was washed with acetone (3×1.0 L). The filtrate was concentrated in vacuo and the residue was extracted with EtOAc (1×10 L, 2×5 L). The organic layers were combined, dried over Na2SO4 (3.0 kg), filtered and concentrated in vacuo. The residue was treated with toluene (1.5 L) and petroleum ether (9 L). The slurry was stirred for 10 hours at −10° C.0° C. The solid was collected, dried at 40° C. to provide pure product Int-16d (1.8 kg, yield: 60percent) as a white solid.
43.4% With potassium permanganate In acetone at 0 - 5℃; for 2 h; To a stirred solution of 269-2 (100 g, 0.47 mol) in acetone (2.0 L) was added KMnO4 (90 g, 0.57 mol) inportions at 0-5° C. The mixture was stirred at 0-5° C. for 2 h. The reaction was quenched using sat. sodiumsulfite solution (600 mL). After 2 h, a colorless suspension was formed. The solid was removed by filtration.The filter cake was washed with EA (300 mL). The filtrate was extracted with EA (3×300 mL). The organicphase was dried over anhydrous Na2SO4. The organic phase was concentrated under reduced pressure to givecrude 269-3 (50 g, 43.4percent) as a solid
770 g With potassium permanganate In acetone at 0 - 5℃; for 5 h; Crude 66-3 (1230 g, 5.74 mol) was dissolved in acetone (30 L) at 0-5° C. KMnO4 (1107 g, 5.17 mol) was added in one portion. After being stirred at 0-5° C. for 5 h, the reaction was quenched with sat. aq. sodium sulfite (20 L). After 30 mins, a colorless suspension was formed. The solid was removed by filtration and washed with EA (6 L). The filtrate was extracted with EA (3×2 L). The combined extracts were dried over Na2SO4, filtered, and concentrated under reduced pressure to give a white solid residue. The residue was dissolved in EA, and PE was added to give a precipitate. The solid was collected by filtration and recrystallization was 3 times to give 66-4 (770 g, 53.6percent) as a white solid.

Reference: [1] Synthesis (Germany), 2018, vol. 50, # 9, p. 1815 - 1819
[2] Patent: US2015/366888, 2015, A1, . Location in patent: Paragraph 1101; 1103
[3] Patent: WO2014/59901, 2014, A1, . Location in patent: Page/Page column 57
[4] Patent: WO2014/59902, 2014, A1, . Location in patent: Page/Page column 56; 57
[5] Patent: CN106146433, 2016, A, . Location in patent: Paragraph 0009; 0028
[6] Patent: US2014/161770, 2014, A1, . Location in patent: Paragraph 0286
[7] Patent: US2015/105341, 2015, A1, . Location in patent: Paragraph 1166
[8] Patent: US2014/179627, 2014, A1, . Location in patent: Paragraph 0507
[9] Patent: US2014/206640, 2014, A1, . Location in patent: Paragraph 0311; 0315
  • 2
  • [ 81997-76-4 ]
  • [ 93635-76-8 ]
YieldReaction ConditionsOperation in experiment
88% With potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride In acetone at -2 - 2℃; for 0.5 h; General procedure: TEBAC (6 mmol) and KMnO4 (6 mmol) were mixed in acetone (10 mL), and the mixture was stirred at r.t. for 3 h then cooled to 0 °C. A solution of the appropriate enoate 1a–14a (5 mmol) in acetone (2 mL) was added dropwise over 5 min while the internal temperature was kept at 5 °C or below. After completion of the addition, the mixture was stirred for a further 30 min at 0 °C until the enoate was completely consumed (TLC). Sat. aq NaHSO3 (5 mL) was added in one portion to quench the reaction, and the mixture was filtered through Celite, which was washed with acetone. The filtrate was concentrated on a rotary evaporator and the residue was extracted with EtOAc. The organic phase was dried (Na2SO4), filtered, and evaporated to dryness.The crude oily product was purified by column chromatography (silica gel, 25percent EtOAc in PE).
72% With tert.-butylhydroperoxide; tetraethylammonium acetate In decane; acetone; <i>tert</i>-butyl alcohol at 0 - 20℃; for 6.5 - 15 h; A 50 mL of flask, equipped with magnetic stirrer, is charged with 2 mL of acetone, 214 mg (1 mmol) of compound 41, 65 mg of Et4NO Ac"4H2O, and 0.3 mL of ter/-butyl hydroperoxide (5 ~ 6 M in decane). After stirring at room temperature until the Et4NOAc a clear solution is obtained, the resulting solution is cooled in an ice bath and 5 mL of OsO4 (2.5 wtpercent in t-BuOH) is added in one portion. The solution immediately becomes brownish purple. After 1 h the ice bath is removed and the reaction mixture is allowed to warm to room temperature and stirred for 14 h. The rest of the procedure is done exactly the same way as described above. After flash column chromatography, 178 mg (72percent) of product is obtained as a solid. In an expanded 1H NMR, a tiny bump is observed at δ 1.26 indicating the presence of an isomer in less than 4percent in the product.; EXAMPLE 10 (2S, 3R)-3-[(4R)-2, 2-Dimethyl-fl , 3]dioxolan-4-yl]-2, 3-dihydroxy-2-methyl- propionic acid ethyl ester (42) t-Butylhydroperoxide as oxidant at 00C with Osmium catalyst. A 250 mL of flask, equipped with magnetic stirrer, is charged with 20 mL of acetone, 2.14 g (10 mmol) of compound 41, 650 mg of Et4NO Ac"4H2O, and 3 mL of hydroperoxide (5 ~ 6 M in decane). After stirring at room temperature until the Et4NOAc has dissolved, the resulting solution is cooled in an ice bath and 5 mL Of OsO4 (2.5 wtpercent in t-BuOH) is added in one portion. The solution immediately becomes brownish purple. The reaction mixture is then stirred at 0 0C for 6.5 h (monitored by TLC, hexanes: ethyl acetate = 4: 1 , Rf = 0.18). Ether (40 mL) is added at 0 0C and the resulting mixture is treated with 5 mL of freshly prepared 10 percent NaHSO3 solution in one portion. The ice bath is removed and stirring is continued for 1 h. EtOAc (100 mL) and H2O (50 mL) are added to the mixture. After separation of the layers, the aqueous phase is further extracted with EtOAc. The organic layer is washed with brine, dried (MgSO4) and concentrated. The residue is purified by a flash silica gel column chromatography with 20 percent EtOAc in hexanes to provide the product (2.16 g, 87percent) as a solid. No contamination of an isomer is detected in this product by vigorous 1H NMR analyses.
67% With pyridine; potassium permanganate In acetone at 0℃; for 1 h; To a solution of compound 41 (214 mg, 1 mmol) in a mixture of acetone (9 mL) and pyridine (1 mL) at 0 0C is added KMnO4 (158 mg, 1.0 mmol) and stirred at same temperature for 1 hr. After work up of the reaction mixture as above, 164 mg (67percent) of white solid which is practically pure product. Vigorous 1H NMR analyses reveal the crude white solid contains about 6percent of the diastere-omer of the titled compound.
59.5% With sodium permanganate; water; sodium hydrogencarbonate In ethylene glycol; acetone at -15 - 10℃; for 4.5 h; Example 3; (2S,3R)-3-[(4R)-2,2-dimemyl-[l,3] dioxolan-4-yl]-2,3-dhydroxy-2- methyl-propionic acid ethyl ester (24)A suspension of 22 (10 kg, CAS Reg. No. 81997-76-4), ethylene glycol (11.6 kg), solid NaHCO3 (11.8 kg) and acetone (150 L) is cooled to ca. -15° C. A solution of 36percent aqueous NaMnO4 (19.5 kg) is charged slowly (over 4 h) to the suspension maintaining reaction temperature at or below -100C. After stirring for 0.5 h at -10° C, an aliquot of the reaction mixture (ca. 5 mL) is quenched with 25percent aqueous sodium bisulfite (ca. 15 mL). A portion of resulting slurry is filtered and submitted for GC analysis to check the progress of the reaction. When the reaction is complete, the reaction mixture is quenched by slow (over 40 min) addition of cooled (ca. 00C) 25percent aqueous NaHSCb (60 L). The temperature of the reaction mixture is allowed to reach 4°C during the quench. CELITE.(R). (ca. 2.5 kg) is then slurried in acetone (8 kg) and added to the dark brown reaction mixture. The resulting slurry is aged at ambient temperature to obtain light tan slurry. The slurry is filtered, and the filter cake is washed with acetone (3 x 39 kg). The combined filtrate is concentrated by vacuum distillation (vacuum approximately 24 inches of Hg (ca. 810 mbar); max pot temperature is 32°C) to remove the acetone. The aqueous concentrate is extracted with EtOAc (3 x 27 kg), and the combined organic extracts were washed with water (25 L). The organic phase is then concentrated by atmospheric distillation and EtOAc is replaced with toluene. The volume of the batch is adjusted to ca. 20 L. Heptane (62 kg) is added and the batch cooled to ca. 27° C to initiate crystallization. The <n="14"/>batch is then cooled to -10° C. After aging overnight at -10° C5 the product is filtered, washed with 10percent toluene in heptane and dried at 500C under vacuum to afford 6.91 kg (59.5percent) of 24 (CA RN 81997-76-4) as a white crystalline solid.
41% With methanesulfonamide; water; potassium carbonate; potassium hexacyanoferrate(III) In <i>tert</i>-butyl alcohol at 0 - 20℃; for 24 h; A 100 mL round-bottomed flask, equipped with a magnetic stirrer, is charged with 5 mL of tert-b\\x\\y\\ alcohol, 5 mL of water, and a mixture Of K3Fe(CN)6 (0.98 g), K2CO3 (0.41 g), and K2OsO2(OH)4 (3.2 mg). Stirring at room temperature produced two clear phases; the lower aqueous phase appears bright yellow. Methanesulfonamide (95 mg) is added at this point. The mixture is cooled to 0 0C whereupon some of salts precipitate out, 214 mg (1 mmol) of the compound 41 is added at once, and the heterogeneous slurry is stirred vigorously at 0 0C for 24 h. To the mixture is added solid sodium sulfite (1.5 g) while stirring at 0 0C, and then the mixture is allowed to warm to room temperature and stirred for 30-60 min. Ethyl acetate (10 mL) is added, and after separation of the layers, the aqueous phase is further extracted with EtOAc. The organic layer is dried over Na2SO4 and concentrated to dryness. The residue is purified by silica gel column chromatography with 20 percent EtOAc in hexanes to provide the product (190 mg, 77percent) as a solid, proton NMR indicates that the ratio of the desired product to its isomer is around 5:1. Recrystallization of the mixture with hexanes/ethyl acetate gave pure diol product (102 mg, 41percent from starting material) as a crystalline solid. The 1H NMR spectrum of this product is identical to that of an authentic specimen.
37.4% With water; 4-methylmorpholine N-oxide In <i>tert</i>-butyl alcohol at 20℃; for 5 h; To a stirred solution of compound 41 (214 mg, 0.1 mmol) in t-BuOH under argon was added a solution of 4-methylmorpholine N-oxide (0.47 mL, 50 wt percent solution in H2O) and water (0.2 mL). A 2.5 wtpercent solution of osmium tetraoxide in tert-bvAy\\ alcohol (0.51 mL) is added, and the mixture is stirred for 5 h at room temperature in a water bath. The mixture is evaporated in vacuo to a syrup, which is azeotroped with H2O (3 x 10 mL) to remove 4-methylmorpholine. The residue is dried by addition and evaporation of EtOH (2 x 10 mL) to give a residue, which was purified by silica gel column chromatography with 20 percent EtOAc in hexanes to provide the desired product and its isomer (196 mg, 79percent) as a solid. Proton NMR indicates that the ratio of the desired product to its isomer is around 5:1. Recrystallization of the mixture from hexanes/ethyl acetate gives pure product (91mg, 37.4percent from starting material) as a crystalline solid. H NMR (DMSO-cfoe) δ 1.18 (t, J= 7.2 Hz, 3H, -OCH2CH3), 1.24 (s, 3H, CH3), 1.25 (s, 3H, CH3), 1.28 (s, 3H, 2-CH3), 3.67 (t, J= 7.2 Hz, 1 H), 3.85, 4.06 and 4.12 (m, 4 H), 4.97 (s, IH, 2- OH, D2O exchangeable), 5.14 (d, J= 7.6 Hz, 2-OH, D2O exchangeable).

Reference: [1] Synthesis (Germany), 2016, vol. 48, # 21, p. 3696 - 3700
[2] Patent: WO2006/31725, 2006, A2, . Location in patent: Page/Page column 12; 34-35
[3] Patent: WO2006/31725, 2006, A2, . Location in patent: Page/Page column 12; 39
[4] Patent: WO2008/45419, 2008, A1, . Location in patent: Page/Page column 12-13
[5] Patent: WO2006/31725, 2006, A2, . Location in patent: Page/Page column 12; 34
[6] Patent: WO2006/31725, 2006, A2, . Location in patent: Page/Page column 12; 33
[7] Patent: WO2006/31725, 2006, A2, . Location in patent: Page/Page column 12; 39
[8] Patent: WO2006/31725, 2006, A2, . Location in patent: Page/Page column 12; 36
[9] Patent: WO2006/31725, 2006, A2, . Location in patent: Page/Page column 12; 37-38
[10] Patent: WO2006/31725, 2006, A2, . Location in patent: Page/Page column 12; 38
[11] Patent: WO2006/31725, 2006, A2, . Location in patent: Page/Page column 12; 36-37
[12] Patent: WO2006/31725, 2006, A2, . Location in patent: Page/Page column 12; 38-39
[13] Journal of Organic Chemistry, 2009, vol. 74, # 17, p. 6819 - 6824
[14] Patent: US2015/366887, 2015, A1, . Location in patent: Paragraph 1033; 1035
  • 3
  • [ 21382-82-1 ]
  • [ 93635-76-8 ]
Reference: [1] Patent: WO2014/59901, 2014, A1,
[2] Patent: WO2014/59902, 2014, A1,
[3] Patent: US2014/179627, 2014, A1,
[4] Patent: US2014/161770, 2014, A1,
[5] Patent: US2014/206640, 2014, A1,
[6] Patent: US2015/105341, 2015, A1,
[7] Patent: US2015/366887, 2015, A1,
[8] Patent: CN106146433, 2016, A,
  • 4
  • [ 15186-48-8 ]
  • [ 93635-76-8 ]
Reference: [1] Patent: WO2014/59901, 2014, A1,
[2] Patent: WO2014/59902, 2014, A1,
[3] Patent: US2014/179627, 2014, A1,
[4] Patent: US2014/161770, 2014, A1,
[5] Patent: US2014/206640, 2014, A1,
[6] Patent: US2015/105341, 2015, A1,
[7] Patent: US2015/366887, 2015, A1,
[8] Patent: CN106146433, 2016, A,
  • 5
  • [ 81997-75-3 ]
  • [ 93635-76-8 ]
  • [ 93636-26-1 ]
Reference: [1] Carbohydrate Research, 1984, vol. 129, p. 99 - 110
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  • [ 21382-82-1 ]
  • [ 15186-48-8 ]
  • [ 93635-76-8 ]
Reference: [1] Patent: US2015/366888, 2015, A1,
  • 7
  • [ 93635-76-8 ]
  • [ 874638-80-9 ]
Reference: [1] Patent: US2013/72699, 2013, A1,
[2] Patent: US2014/179627, 2014, A1,
[3] Patent: CN106146433, 2016, A,
[4] Patent: CN106366057, 2017, A,
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tert-Butyl (3R,5S)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate

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Chemical Structure| 154026-95-6

[ 154026-95-6 ]

tert-Butyl 2-((4R,6S)-6-(acetoxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

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Chemical Structure| 189509-22-6

[ 189509-22-6 ]

Ethyl 2-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate

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Chemical Structure| 124752-23-4

[ 124752-23-4 ]

tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate

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Chemical Structure| 91912-46-8

[ 91912-46-8 ]

2-(Carboxymethyl)-5-oxotetrahydrofuran-2-carboxylic acid

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Dioxolanes

Chemical Structure| 189509-22-6

[ 189509-22-6 ]

Ethyl 2-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate

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Chemical Structure| 78086-72-3

[ 78086-72-3 ]

(4R,5S)-Methyl 2,2,5-trimethyl-1,3-dioxolane-4-carboxylate

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Chemical Structure| 1489-97-0

[ 1489-97-0 ]

Ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

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Chemical Structure| 1006686-08-3

[ 1006686-08-3 ]

Ethyl 8-formyl-1,4-dioxaspiro[4.5]decane-8-carboxylate

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Chemical Structure| 24730-88-9

[ 24730-88-9 ]

Ethyl 8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate

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