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CAS No. :	939981-39-2
Formula :	C₃₈H₄₈Cl₂N₄O₄S
M.W :	727.78
SMILES Code :	C[C@@]1([C@](C)(N(C(C2=CC=C(C=C2OCC)C(C)(C)C)=N1)C(N3CCN(CC3)CCCS(=O)(C)=O)=O)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Synonyms :	RO5045337
MDL No. :	MFCD18206914
InChI Key :	QBGKPEROWUKSBK-QPPIDDCLSA-N
Pubchem ID :	57406853

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

CML CD34+ cells	50nM	24h	Assess the effect of RG7112 on CML CD34+ cells, results showed that RG7112 significantly increased p53 expression.	PMC4913876
K562 cells	50µM	72h	Assess the effect of RG7112 on K562 cells, results showed that K562 cells were unresponsive to RG7112 due to lack of p53.	PMC4913876
GBM cell lines	0.52 μM	72 hours	To evaluate the effect of RG7112 on cell proliferation and viability, results showed that MDM2-amplified cell lines were highly sensitive to RG7112 with an IC50 of 0.52 μM.	PMC4842012
MDM4-amplified GBM cell lines	1.2 μM	72 hours	To evaluate the effect of RG7112 on MDM4-amplified GBM cell lines, results showed that these cell lines exhibited intermediate sensitivity to RG7112 with an IC50 of 1.2 μM.	PMC4842012
H1299 cells	5 μM	2 hours	RG7112 blocks TOP2 β degradation by interfering with the association of MDM2 with TOP2 β, extending its half-life.	PMC10806188
A549 cells	5 μM	2 hours	RG7112 blocks TOP2 β degradation by interfering with the association of MDM2 with TOP2 β, extending its half-life.	PMC10806188
NALM6	3.2 μM	48 hours	To evaluate the cytotoxicity of RG7112 on p53 wild-type leukemia cells, the IC50 for NALM6 cells was 3.2 μM	PMC4359964
RS4;11	1.4 μM	48 hours	To evaluate the cytotoxicity of RG7112 on p53 wild-type leukemia cells, the IC50 for RS4;11 cells was 1.4 μM	PMC4359964
JURKAT	>10 μM	48 hours	To evaluate the cytotoxicity of RG7112 on p53 mutant leukemia cells, the IC50 for JURKAT cells was >10 μM	PMC4359964
CEM	>10 μM	48 hours	To evaluate the cytotoxicity of RG7112 on p53 mutant leukemia cells, the IC50 for CEM cells was >10 μM	PMC4359964
MLL-ALL xenograft cells	0.1-0.35 μM	48 hours	To evaluate the cytotoxicity of RG7112 on MLL-ALL xenograft cells, the IC50 was 0.1-0.35 μM	PMC4359964
MSTO-211H	0.15 µM	3 days	RG7112 showed inhibitory effects on mesothelioma cells with wild-type p53, with an IC50 value of 2.55 ± 0.43 µM	PMC8260618
NCI-H226	0.15 µM	3 days	RG7112 showed inhibitory effects on mesothelioma cells with wild-type p53, with an IC50 value of 2.55 ± 0.43 µM	PMC8260618
NCI-H28	0.15 µM	3 days	RG7112 showed inhibitory effects on mesothelioma cells with wild-type p53, with an IC50 value of 2.55 ± 0.43 µM	PMC8260618

mice	SCL-tTA-BCR-ABL double transgenic leukaemia model	oral	10 μM	5 days	Assess the effect of RG7112 on leukaemic stem cells, results showed that RG7112 in combination with CPI-0610 significantly reduced the survival of leukaemic stem cells.	PMC4913876
Nude mice	xenograft GBM models	oral	7 mg/kg	Injected on days 1, 5, and 9, totaling 3 times	To evaluate the efficacy of RG7112 in MDM2-amplified GBM models, results showed that RG7112 significantly inhibited tumor growth and prolonged survival in mice.	PMC4842012
Mice	Wild-type mice	Oral gavage	30 mg/kg	Once daily for 5 days	Enhance p53 activity, protect mice from radiation-induced gastrointestinal toxicity	PMC6717251
BALB/c nude mice	H1299 tumor xenograft model	intravenous injection	50 μmol/kg and 100 μmol/kg	Once daily for 14 days	The combination of RG7112 with VP-16 synergistically inhibited tumor growth, reduced tumor volume and weight, and induced tumor cell apoptosis.	PMC10806188
NOD/SCID mice	MLL-ALL xenograft model	Oral	50 mg/kg	Twice, 6 hours apart	To evaluate the in vivo efficacy of RG7112 against MLL-ALL xenograft models, results showed that RG7112 significantly prolonged mouse event-free survival and induced p53 up-regulation, cell cycle arrest, and apoptosis	PMC4359964
BALB/c nu/nu mice	mesothelioma xenograft model	intraperitoneal injection	25 mg/kg	three times on days 0, 3 and 6	RG7112 alone inhibited tumor growth, and the combination with Ad-delE1B further reduced tumor weight	PMC8260618

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CAS No.: 939981-39-2

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CAS No.: 939981-39-2

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NCT00623870	Hematologic Neoplasms	PHASE1	COMPLETED	2025-11-12	Duarte, California, 91010, Uni... More >>ted States\|New Brunswick, New Jersey, 08901, United States\|New York, New York, 10065, United States\|Houston, Texas, 77030, United States\|Toronto, Ontario, M5G 2M9, Canada\|Montreal, Quebec, H3T 1E2, Canada\|Bologna, Emilia-Romagna, 40138, Italy\|Roma, Lazio, 00161, Italy\|Glasgow, G12 0YN, United Kingdom\|Leeds, LS9 7TF, United Kingdom\|Oxford, OX3 7LJ, United Kingdom Less <<
NCT00559533	Neoplasms	PHASE1	COMPLETED	2025-11-12	Aurora, Colorado, 80045, Unite... More >>d States\|Boston, Massachusetts, 02115, United States\|New York, New York, 10065, United States\|Houston, Texas, 77030, United States\|San Antonio, Texas, 98229, United States\|Bordeaux, 33076, France\|Lyon, 69373, France Less <<
NCT01143740	Sarcoma	PHASE1	COMPLETED	2025-03-11	Bordeaux, 33076, France\|Lille,... More >> 59020, France\|Lyon, 69373, France\|Villejuif, 94805, France Less <<
NCT01164033	Neoplasms	PHASE1	COMPLETED	2025-05-13	Scottsdale, Arizona, 85258, Un... More >>ited States\|Kansas City, Kansas, 66160-7330, United States\|Kensignton, Maryland, 20895, United States\|Dallas, Texas, 75230, United States\|San Antonio, Texas, 98229, United States Less <<
NCT01677780	Myelogenous Leukemia, Chronic,... More >> Neoplasms, Myelogenous Leukemia, Acute Less <<	PHASE1	COMPLETED	2017-06-26	Sarcoma Oncology Center, Santa... More >> Monica, California, 90403, United States\|M.D Anderson Cancer Center; Oncology, Houston, Texas, 77030, United States\|Cancer Therapy & Research Ctr; Dept Institute for Drug Development, San Antonio, Texas, 78229, United States\|Princess Margaret Hospital, Medical Oncology & Haematology, Toronto, Ontario, M5G 2M9, Canada\|Institut Claudius Regaud; Departement Oncologie Medicale, Toulouse, 31059, France Less <<

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed