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[ CAS No. 941294-26-4 ]

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Chemical Structure| 941294-26-4
Chemical Structure| 941294-26-4
Structure of 941294-26-4 * Storage: {[proInfo.prStorage]}

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Product Details of [ 941294-26-4 ]

CAS No. :941294-26-4 MDL No. :MFCD09800928
Formula : C8H7ClN4 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :194.62 g/mol Pubchem ID :-
Synonyms :

Safety of [ 941294-26-4 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 941294-26-4 ]

  • Downstream synthetic route of [ 941294-26-4 ]

[ 941294-26-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 214614-91-2 ]
  • [ 941294-26-4 ]
  • [ 1443297-46-8 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 180℃; for 1.5h; Sealed tube; Microwave irradiation; 13 Example 13 6-fluoro-1 -(1 -(6-(4-methyl-1 H-imidazol-1 -yl)pyridazin-3-yl)piperidin-4- vDindoline (Compound 4) Example 13 6-fluoro-1 -(1 -(6-(4-methyl-1 H-imidazol-1 -yl)pyridazin-3-yl)piperidin-4- vDindoline (Compound 4) To a mixture of 6-fluoro-1-(piperidin-4-yl)indoline (128 mg, 0.5 mmol), 3- chloro-6-(4-methylimidazol-1-yl)pyridazine (78 mg, 0.4 mmol) in DMSO (1 .5 mL) was added DIPEA (0.25 mL, 1.5 mmol). The resulting mixture was sealed and heated at 180°C for 1.5h under microwave irradiation. The resulting mixture was then poured into H20 (30 mL) and the aqueous layer was extracted with 10% CH2Cl2/Et20 (80 mL x 4). The combined organic layer was dried (Na2S04) and filtered. The solvent was removed and the resulting residue was purified by column (dry loading) using EtOAc then 3% MeOH/EtOAc as the eluent to yield 6-fluoro-1-(1-(6-(4-methyl-1 H-imidazol-1 - yl)pyridazin-3-yl)piperidin-4-yl)indoline. 1H NMR (400MHz ,CHLOROFORM-d) δ = 8.15 (d, J = 1.3 Hz, 1 H), 7.29-7.37 (m, 2 H), 7.12 (d, J = 9.6 Hz, 1 H), 6.89-6.97 (m, 1 H), 6.28 (ddd, J = 2.3, 7.9, 9.8 Hz, 1 H), 6.15 (dd, J = 2.1 , 10.5 Hz, 1 H), 4.47-4.60 (m, 2 H), 3.53- 3.69 (m, 1 H), 3.40 (t, J = 8.5 Hz, 2 H), 3.01 -3.15 (m, 2 H), 2.91 (t, J = 8.3 Hz, 2 H), 2.31 (s, 3 H), 1.88-2.01 (m, 2 H), 1 .67-1.84 (m, 2 H); MS: 379 (M++1 ).
  • 2
  • [ 141-30-0 ]
  • [ 822-36-6 ]
  • [ 941294-26-4 ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate In acetonitrile for 3h; Reflux; General procedure: To a mixture of 3,6-dichloropyridazine (3.73 g, 25 mmol), 4(5)-Hydroxymethylimidazole (1.96 g, 20 mmol), and Cs2CO3 (8.14 g, 25 mmol) was added acetonitrile (80 mL). The mixture was refluxed for 3 h and was poured into H2O (200 mL). 1N HCl(aq) was added slowly until the pH is ca. 7-8. Then the aqueous layer was extracted with EtOAc (150 mL) and then CH2Cl2 (100 mL x 5). The combined organic layer was dried (Na2SO4) and filtered. After removal of solvent, the product was triturated with 10% CH2Cl2/Et2O (30 mL x 3) to give 1.74 g of product. The filtrate was concentrated and was purified by column using 60-70-80% EtOAc/(CH2Cl2/hexane=1/1) as the eluent to give 629 mg of prouct. Total 2.36g of D (53%) was obtained.
  • 3
  • [ 1443248-83-6 ]
  • [ 941294-26-4 ]
  • [ 1443297-46-8 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 180℃; for 1.5h; Microwave irradiation; General procedure: To a mixture of B (100 mg, 0.4 mmol), D (63 mg, 0.3 mmol) in DMSO (1.5 mL) was added (i-Pr)2NEt (0.16 mL, 0.9 mmol). The mixture was sealed and heated at 180 °C for 1.5 h under microwave irradiation. The mixture was poured into H2O (30 mL) and the aqueous layer was extracted with 10% CH2Cl2/Et2O (80 mL x 4). The combined organic layer was dried (Na2SO4) and filtered. After removal of solvent, the crude product was purified by column using EtOAc then 3-5% MeOH/EtOAc as the eluent to give 62 mg of 4b (53%).
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