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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
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Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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CAS No. : | 942060-13-1 | MDL No. : | MFCD16607557 |
Formula : | C7H8BrNO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | ZIXRHBYSNLQDQM-UHFFFAOYSA-N |
M.W : | 202.05 | Pubchem ID : | 57574512 |
Synonyms : |
|
Num. heavy atoms : | 10 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.29 |
Num. rotatable bonds : | 2 |
Num. H-bond acceptors : | 2.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 43.56 |
TPSA : | 22.12 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.31 cm/s |
Log Po/w (iLOGP) : | 2.14 |
Log Po/w (XLOGP3) : | 1.72 |
Log Po/w (WLOGP) : | 1.83 |
Log Po/w (MLOGP) : | 1.39 |
Log Po/w (SILICOS-IT) : | 2.33 |
Consensus Log Po/w : | 1.88 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.49 |
Solubility : | 0.656 mg/ml ; 0.00325 mol/l |
Class : | Soluble |
Log S (Ali) : | -1.8 |
Solubility : | 3.2 mg/ml ; 0.0158 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -3.42 |
Solubility : | 0.0777 mg/ml ; 0.000385 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.9 |
Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P260-P264-P280-P301+P310+P330+P331-P303+P361+P353+P310-P304+P340+P310-P305+P351+P338+P310-P363-P405-P501 | UN#: | 3265 |
Hazard Statements: | H314 | Packing Group: | Ⅱ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With N-Bromosuccinimide; triphenylphosphine In dichloromethane at 20℃; for 2 h; | Step 2: 3-(Bromomethyl)-2-methoxypyridine Int-37 To a solution of (2-methoxypyridin-3-yl)methanol (811 mg, 5.8 mmol) and N- bromosuccinimide (1.24 g, 7.0 mmol) in DCM (10 mL) was added triphenylphosphine (1.8 g, 7.0 mmol) at rt and the mixture was stirred for 2 h. The mixture was quenched with water and extracted with EtOAc. The organic layer was washed with brine, dried over Na2S04 and concentrated. The crude product was purified on silica gel to give 3-(bromomethyl)-2-methoxypyridine (829 mg, 70percent) as clear oil. FontWeight="Bold" FontSize="10" H NMR (CDC13) 8.14 (dd, J= 5.0, 1.9 Hz, 1H), 7.63 (dd, J- 7.3, 1.9 Hz, 1H), 6.89 (dd, J= 7.3, 5.0 Hz, 1H), 4.51 (s, 2H), 4.04 (s, 3H). |
42% | With carbon tetrabromide; triphenylphosphine In dichloromethane at 20℃; for 16 h; | Example 139: Preparation of 3-bromomethyl-2-methoxy-pyridineTo a solution of [2-methoxy-pyridin-3-yl]-methanol (0.849 g, 6.11 mmol) (Example 138) in dichloromethane (30 ml) was added sequentially triphenyl phosphine (1.683 g, 6.42 mmol) and carbon tetrabromide (1.904 g, 5.81 mmol). The reaction mixture was stored at room temperature for 16 hours. The reaction mixture was concentrated and the residue purified by column chromatography on silica gel (eluent: 0- 25percent ethyl acetate in hexane) to give 3-bromomethyl-2-methoxy-pyridine as a colourless oil (0.511 g, 42percent yield). 'H-NMR (400 MHz, CDCl3): 4.02 (3H, s, Me), 4.5 (2H, m, CH2), 6.88 (IH, m, CH), 7.61 (IH, m, CH), 8.12 (IH, m, CH) ppm. |
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