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[ CAS No. 943847-26-5 ] {[proInfo.proName]}

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Chemical Structure| 943847-26-5
Chemical Structure| 943847-26-5
Structure of 943847-26-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 943847-26-5 ]

CAS No. :943847-26-5 MDL No. :MFCD19288133
Formula : C10H6BrNO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 236.06 Pubchem ID :-
Synonyms :

Safety of [ 943847-26-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 UN#:N/A
Hazard Statements:H302-H312-H332 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 943847-26-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 943847-26-5 ]

[ 943847-26-5 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 943847-25-4 ]
  • [ 943847-26-5 ]
YieldReaction ConditionsOperation in experiment
With Dess-Martin periodane In dichloromethane at 20℃; for 0.5h; 4.B To a stirred solution of the crude alcohol (2.0 g, 8.3 mrnol) in dichloromethane (60 mL) was added slowly l,l,l-tϖs(acetoxy)-l,l-dihydro-l,2-benziodoxol-3(lH)-one (Dess- Martin periodinane) (4.0 g, 9.4 mmol) at room temperature. After stirring for 0.5 h, the reaction mixture was diluted with dichloromethane, washed with saturated aqueous sodium bicarbonate and brine, dried (Na2SO4), and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel using hexanes/ethyl acetate as eluent to afford the title product as a white solid (1.8 g). IH NMR (CDCl3): 10.31 (s, IH), 9.65 (dd, IH), 9.12 (dd, IH), 8.26 (d, IH), 7.88 (d, IH),7.66 (dd, IH).
With Dess-Martin periodane In dichloromethane
  • 2
  • [ 943847-26-5 ]
  • [ 943847-27-6 ]
YieldReaction ConditionsOperation in experiment
98% With hydroxylamine In ethanol
With hydroxylamine In ethanol; water at 20℃; for 2h; 4.C To a stirred solution of 8-bromo-5-quinolinecarboxaldehyde (i.e. the product from StepB) (1.7 g, 7.1 mmol) in ethanol (30 mL) was added an aqueous solution of hydroxylamine (0.7 mL, 50% in water). After stirring at room temperature for 2 h, the reaction mixture was concentrated under reduced pressure to provide the title compound as a pale yellow solid(1.8 g).1H NMR (DMSO-^6): 11.61 (s, IH), 9.16 (dd, IH), 9.07 (dd, IH), 8.79 (s, IH), 8.20 (d, IH),7.79 (d, IH), 7.72 (dd, IH).
  • 3
  • [ 823803-51-6 ]
  • [ 943847-26-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane 2: N,N-dimethyl-formamide 3: potassium carbonate / methanol 4: Dess-Martin periodane / dichloromethane
  • 4
  • [ 823803-53-8 ]
  • [ 943847-26-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide 2: potassium carbonate / methanol 3: Dess-Martin periodane / dichloromethane
  • 5
  • [ 943847-24-3 ]
  • [ 943847-26-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: potassium carbonate / methanol 2: Dess-Martin periodane / dichloromethane
  • 6
  • [ 943847-26-5 ]
  • 5-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-(2-pyridinylmethyl)-8-quinolinecarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: hydroxylamine / ethanol 2: N-chloro-succinimide; triethylamine / N,N-dimethyl-formamide 3: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene
  • 7
  • [ 943847-26-5 ]
  • [ 943847-28-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: hydroxylamine / ethanol 2: N-chloro-succinimide; triethylamine / N,N-dimethyl-formamide
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