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[ CAS No. 945614-14-2 ] {[proInfo.proName]}

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Chemical Structure| 945614-14-2
Chemical Structure| 945614-14-2
Structure of 945614-14-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 945614-14-2 ]

CAS No. :945614-14-2 MDL No. :MFCD18204992
Formula : C14H10FNO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 227.24 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 945614-14-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

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[ 945614-14-2 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 945614-14-2 ]
  • [ 91407-41-9 ]
YieldReaction ConditionsOperation in experiment
100% With hydrogen In methanol at 20℃; for 3 h; Dry 10percent Pd/C(2.48 g) was placed in a 5 L flask under N2. A solution of 2-(benzyloxy)-5-fluorobenzonitrile (148 g, 651 mmol) in methanol (2.34 L) was added slowly under N2. The air of the flask was removed by vacuum and the flask was charged with H2 (balloon) three times. The mixture was stirred at room temperature for 1 hour. The above process was repeated two more times to push the reaction to completion. The mixture was stirred at room temperature for another 2 hours. The mixture was filtered through a Celite pad under N2 and washed with EtOAc (150 mL x 2). The palladium waste was rinsed with water (50 mL) and discarded. The filtrates were concentrated to give (94.6 g, 106 percent) of the desired compound as a yellow solid. MS (APCI -) m/z 137 (M-I) was detected. 1H NMR (400 MHz, DMSOd6) δ 11.07 (br, IH), 7.58 (dd, IH, J= 3.2 Hz, J = 8.2 Hz), 7.43 (m, IH), 6.91-7.03 (dd, IH J = 4.5 Hz, J = 9.2 Hz).
Reference: [1] Patent: WO2007/89646, 2007, A1, . Location in patent: Page/Page column 12; 45
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