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CAS No. : | 95395-23-6 | MDL No. : | MFCD06800600 |
Formula : | C12H11NO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 217.22 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With sodium hydroxide; for 2h;Reflux; | To a solution of <strong>[68236-20-4]2-chloro-7-methoxyquinoline-3-carbaldehyde</strong> (0.23 g, 1.04 mmol, 1eq) in methanol (6 mL) was added sodium hydroxide (0.20 g,5 mmol, 4.8 eq). The reaction mixture was refluxed for 2 h. Theresulting solution is poured into ice. The precipitate was filtered crystallized from methanol to give a yellow powder. Yield: 95%; m.p 160 C; NMR 1H d (ppm) (300 MHz, CDCl3): 10.35 (s, 1H, CHO),8.45 (s, 1H, H4), 7.68 (d, 1H, H5), 7.18 (d, 1H, H8), 7.0 (d, 1H, H6), 4.10(s, 3H, 2-OCH3), 3.90 (s, 3H, 7-OCH3). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With methanol; sodium for 5h; Reflux; | 5.1.11 General procedure for preparation of 6-(substituted-2-methoxyquinolin-3-yl)-1-substituted phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (11a-r) General procedure: A mixture of or 5-amino-1-(4-phenyl)-1H-pyrazole-4-carboxamides (10a) or 5-amino-1-(4-bromophenyl)-1H-pyrazole-4-carboxamides (10b) (1mmol) and the appropriate 2-methoxy quinolone-3-carboxaldehydes 4a-i (1mmol) were dissolved in methanol (20mL) containing sodium metal (0.05g, 2mmol) and allowed to be stirred under reflux for 5h. The reaction was cooled and the precipitated products was filtered, dried and crystallized from DMF. |