Structure of Nedaplatin
CAS No.: 95734-82-0
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Nedaplatin is a derivative of cisplatin and DNA damage agent.
Synonyms: NSC 375101D; NSC 375101
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 95734-82-0 |
Formula : | C2H8N2O3Pt |
M.W : | 303.17 |
SMILES Code : | O=C1[O-][Pt+2]([NH3])([NH3])[O-]C1 |
Synonyms : |
NSC 375101D; NSC 375101
|
MDL No. : | MFCD00866374 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302 |
Precautionary Statements: | P280-P305+P351+P338 |
Target |
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In Vitro:
Concentration | Treated Time | Description | References |
HEK293 | 0.5, 1, 2, 4, 8, 10, 20 μg/mL | 72 hours | Evaluate the cytotoxicity of free and liposomal Nedaplatin on HEK293 cells. Results showed no significant increase in cytotoxicity with liposomal Nedaplatin. | PMC7559812 |
WI-38 | 0.5, 1, 2, 4, 8, 10, 20 μg/mL | 72 hours | Evaluate the cytotoxicity of free and liposomal Nedaplatin on WI-38 cells. Results showed no significant increase in cytotoxicity with liposomal Nedaplatin. | PMC7559812 |
U2OS | 0.5, 1, 2, 4, 8, 10, 20 μg/mL | 72 hours | Evaluate the cytotoxicity of free and liposomal Nedaplatin on U2OS cells. Results showed that liposomal Nedaplatin significantly reduced cell viability at lower concentrations. | PMC7559812 |
A549 | 0.5, 1, 2, 4, 8, 10, 20 μg/mL | 72 hours | Evaluate the cytotoxicity of free and liposomal Nedaplatin on A549 cells. Results showed that liposomal Nedaplatin significantly increased cytotoxicity at all tested concentrations. | PMC7559812 |
MDA-MB-468 | 0.067 µM | 24 hours | Evaluate the cytotoxicity of nedaplatin on TNBC cells, results showed cytotoxicity to MDA-MB-468 cells at the highest tested dose | PMC10825133 |
BT-549 | 0.15 µM | 24 hours | Evaluate the cytotoxicity of nedaplatin on TNBC cells, results showed high cytotoxicity to CAL-148 cells at the highest tested dose | PMC10825133 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Zebrafish | HCC1806 and MCF-7 cell xenograft models | 25 µM | 48 hours | Evaluate the effect of nedaplatin combined with bortezomib on tumor regression, results showed reduced tumor volume | PMC10825133 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03328234 | IMRT With or Without Concurren... More >>t Chemotherapy for Esophageal Cancer Less << | Phase 3 | Recruiting | December 31, 2022 | China ... More >> Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) Recruiting Beijing, China, 100021 Contact: Xin Wang, MD +861013311583220 beryl_wx2000@163.com Less << |
NCT03731442 | Esophageal Cancer | Phase 3 | Recruiting | October 31, 2027 | China, Beijing ... More >> Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) Recruiting Beijing, Beijing, China, 100021 Contact: Zefen Xiao, MD Less << |
NCT03308552 | Esophageal Neoplasms | Phase 3 | Recruiting | August 30, 2021 | China, Beijing ... More >> Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) Recruiting Beijing, Beijing, China, 100021 Contact: Zefen Xiao, MD Less << |
NCT03529279 | Nasopharyngeal Carcinoma | Phase 3 | Not yet recruiting | June 12, 2026 | - |
NCT03290820 | Nasopharyngeal Carcinoma | Phase 2 | Not yet recruiting | September 30, 2024 | China, Guangdong ... More >> Sun Yat-sen University Cancer Center Not yet recruiting Guangzhou, Guangdong, China, 510060 Contact: Hui Chang, M.D 86-020-87343374 changhui@sysucc.org.cn Contact: Chen Chen, M.D chenchen@sysucc.org.cn Principal Investigator: Yun-fei Xia, M.D Less << |
NCT03661567 | Non-small Cell Lung Cancer | Phase 2 | Recruiting | September 2021 | China, Guangdong ... More >> Sun yat-sen University Cancer Center Recruiting Guangzhou, Guangdong, China, 510000 Contact: Bo Qiu, Attending +86-020-87343031 qiubo@sysucc.org.cn Contact: Hui Liu, Professor Less << |
NCT03663764 | Thymoma and Thymic Carcinoma | Phase 2 | Recruiting | August 2023 | China, Guangdong ... More >> Sun yat-sen University Cancer Center Recruiting Guangzhou, Guangdong, China, 510000 Contact: Bo Qiu, Attending +86-020-87343031 qiubo@sysucc.org.cn Contact: Hui Liu, Professor Less << |
NCT03344068 | Nasopharyngeal Carcinoma ... More >> Nutritional Support Less << | Phase 2 Phase 3 | Not yet recruiting | March 31, 2021 | China, Guangdong ... More >> Department of Radiation Oncology, Sun Yat-Sen University Cancer Center Guangzhou, Guangdong, China, 510060 Less << |
NCT02721563 | Esophageal Neoplasms | Phase 2 | Recruiting | December 2018 | China, Shandong ... More >> Qianfoshan Hospital of Shandong Recruiting Jinan, Shandong, China, 250117 Contact: Jiandong Zhang 13583123486 Qilu Hospital of Shandong University Not yet recruiting Jinan, Shandong, China, 250117 Contact: Yufeng Cheng 13869199969 Shandong Cancer Hospital and Institute Recruiting Jinan, Shandong, China, 250117 Contact: Jinming Yu 8653167626891 Jining NO.1 People's Hospital Recruiting Jining, Shandong, China, 250117 Contact: Peipei Wu 15853770581 Liaocheng People 's Hospital Recruiting Liaocheng, Shandong, China Contact: Mingjun Li, MD Qingdao Center Medical Group Recruiting Qingdao, Shandong, China, 250117 Contact: Xuezhen Ma 18660221959 Rizhao City People 's Hospital Recruiting Rizhao, Shandong, China Contact: yufeng li Fei Cheng People's Hospital Recruiting Tai'an, Shandong, China, 250117 Contact: Wenyuan Zhao 13518688689 An Qiu People's Hospital Recruiting Weifang, Shandong, China, 250117 Contact: Chuandong Wang 15605368369 The Fourth People's Hospitalof Zibo Recruiting Zibo, Shandong, China, 250117 Contact: Qiang Zhang 13345221111 Less << |
NCT03659578 | Non-small Cell Lung Cancer | Phase 2 | Recruiting | September 2020 | China, Guangdong ... More >> Sun yat-sen University Cancer Center Recruiting Guangzhou, Guangdong, China, 510000 Contact: Bo Qiu, Attending +86-020-87343031 qiubo@sysucc.org.cn Contact: Hui Liu, Professor Less << |
NCT02721576 | Esophageal Neoplasms | Phase 2 | Recruiting | December 2018 | China, Shandong ... More >> Qianfoshan Hospital of Shandong Recruiting Jinan, Shandong, China, 250117 Contact: Jiandong Zhang 13583123486 Shandong Cancer Hospital and Institute Recruiting Jinan, Shandong, China, 250117 Contact: Jinming Yu 8653167626891 Jining NO.1 People's Hospital Recruiting Jining, Shandong, China, 250117 Contact: Peipei Wu 15853770581 Liaocheng People Hospital Recruiting Liaocheng, Shandong, China Contact: mingjun Li Qingdao Center Medical Group Recruiting Qingdao, Shandong, China, 250117 Contact: Xuezhen Ma 18660221959 Rizhao City People 's Hospital Recruiting Rizhao, Shandong, China Contact: Yufeng Li Fei Cheng People's Hospital Recruiting Tai'an, Shandong, China, 250117 Contact 13518688689 An Qiu People's Hospital Recruiting Weifang, Shandong, China, 250117 Contact: Chuandong Wang 15605368369 The Fourth People's Hospitalof Zibo Recruiting Zibo, Shandong, China, 250117 Contact: Qiang Zhang 13345221111 Less << |
NCT03673657 | Local Advanced Non-small Cell ... More >>Lung Cancer Less << | Phase 2 | Recruiting | August 2022 | China, Guangdong ... More >> Sun yat-sen University Cancer Center Recruiting Guangzhou, Guangdong, China, 510000 Contact: Bo Qiu, Attending +86-020-87343031 qiubo@sysucc.org.cn Contact: Hui Liu, Professor Less << |
NCT02721550 | Esophageal Neoplasms | Phase 2 | Recruiting | December 2018 | China, Shandong ... More >> Qianfoshan Hospital of Shandong Recruiting Jinan, Shandong, China, 250117 Contact: Jiandong Zhang 13583123486 Shandong Cancer Hospital and Institute Recruiting Jinan, Shandong, China, 250117 Contact: Jinming Yu Jining NO.1 People's Hospital Recruiting Jining, Shandong, China, 250117 Contact: Peipei Wu 15853770581 Liaocheng People Hospital Recruiting Liaocheng, Shandong, China Contact: Mingjun Li Qingdao Center Medical Group Recruiting Qingdao, Shandong, China, 250117 Contact: Xuezhen Ma Rizhao City People 's Hospital Recruiting Rizhao, Shandong, China Contact: Yufeng Li Fei Cheng People's Hospital Recruiting Tai'an, Shandong, China, 250117 Contact: Wenyuan Zhao 13518688689 An Qiu People's Hospital Recruiting Weifang, Shandong, China, 250117 Contact: Chuandong Wang 15605368369 The Fourth People's Hospitalof Zibo Recruiting Zibo, Shandong, China, 250117 Contact: Qiang Zhang 13345221111 Less << |
NCT01137123 | Thoracic Esophageal Squamous C... More >>ell Carcinoma Less << | Phase 3 | Recruiting | December 2020 | China, Guangdong ... More >> Sun Yat-sen Uniersity Cancer Center Recruiting GuangZhou, Guangdong, China, 510060 Contact: Peng Lin, Professor +86-20-87343314 linpeng@sysucc.org.cn Contact: Jun Zeng +86-20-87343736 xingrp@sysucc.org.cn Principal Investigator: Peng Lin, Professor Less << |
NCT02573506 | Non-small Cell Lung Cancer | Phase 2 | Active, not recruiting | July 2020 | China, Guangdong ... More >> Hui Liu Guangzhou, Guangdong, China, 510000 Less << |
NCT02430974 | Carcinoma, Non-Small-Cell Lung | Phase 2 | Unknown | January 2018 | - |
NCT02777788 | Cancer | Phase 2 Phase 3 | Active, not recruiting | December 2019 | - |
NCT02858206 | Esophageal Neoplasms | Phase 2 | Recruiting | November 2021 | China, Beijing ... More >> Zefen Xiao Recruiting Beijing, Beijing, China, 100021 Contact: Zefen Xiao, MD 8610-87787643 xiaozefen@sina.com Contact: Wei Deng, MD +8618813019080 sherrydw@126.com Less << |
NCT02279134 | Esophageal Neoplasms ... More >> Esophageal Cancer Less << | Phase 2 Phase 3 | Recruiting | October 2022 | China, Beijing ... More >> Cancer Institute and Hospital, Chinese Academy of Medical Science Recruiting Beijing, Beijing, China, 100021 Contact: Zefen Xiao, MD 8610-87787463 xiaozefen@sina.com Contact: Shufei Yu, MD 86-15911070901 sophie314@yeah.net Less << |
NCT02429622 | Esophageal Neoplasms | Phase 1 Phase 2 | Completed | - | China, Beijing ... More >> Zefen Xiao Beijing, Beijing, China, 100021 Less << |
NCT03649945 | Esophageal Cancer | Phase 2 | Not yet recruiting | May 2021 | - |
NCT01712919 | Nasopharyngeal Carcinoma | Phase 1 Phase 2 | Completed | - | China, Jiangsu ... More >> Jiangsu Cancer Hospital Nanjing, Jiangsu, China, 210009 Less << |
NCT03006575 | Non-small Cell Lung Cancer | Phase 2 | Recruiting | July 2021 | China, Guangdong ... More >> Hui Liu Recruiting Guangzhou, Guangdong, China, 510000 Contact: Hui Liu, professor +86-020-87343031 liuhui@sysucc.org.cn Less << |
NCT01694576 | Nasopharyngeal Carcinoma | Phase 2 | Terminated(slow patient enroll... More >>ment) Less << | October 2015 | China, Jiangsu ... More >> Jiangsu Cancer Hospital Nanjing, Jiangsu, China, 210009 Less << |
NCT01201044 | Non-small Cell Lung Cancer | Not Applicable | Unknown | December 2012 | China ... More >> The 3rd Affiliated Hospital of the 3rd Military Hospital Recruiting Chongqing, China Contact: Yi Li +86-13452081471 Sub-Investigator: YI LI Less << |
NCT02364804 | - | Unknown | September 2015 | Japan ... More >> Shiga University of Medical Science Hospital Otsu, Shiga, Japan, 520-2192 Less << | |
NCT03603756 | Esophageal Squamous Cell Carci... More >>noma Less << | Phase 2 | Recruiting | March 28, 2021 | China ... More >> Jing Huang Recruiting Beijing, China Contact: Jing Huang, MD Less << |
NCT01040312 | - | Unknown | March 2014 | Japan ... More >> Department of Obstetrics and Gynecology, National Defense Medical College Hospital Tokorozawa, Saitama, Japan, 359-8513 Less << | |
NCT00197444 | Esophageal Cancer ... More >> Squamous Cell Carcinoma Less << | Phase 2 | Completed | - | Japan ... More >> First Department of Medicine, Hamamatsu University School of Medicine Hamamatsu, Japan, 431-3192 Less << |
NCT01735747 | Central Nervous System Tumors | Phase 2 | Unknown | November 2013 | China, Shandong ... More >> Neurosurgery, Shandong Cancer Hospital and Institute Jinan, Shandong, China, 250117 Less << |
NCT02789189 | Recurrent and Metastatic Nasop... More >>haryngeal Carcinoma Less << | Phase 2 | Not yet recruiting | - | - |
NCT03503136 | Nasopharyngeal Carcinoma | Phase 3 | Not yet recruiting | June 2026 | China, Guangdong ... More >> Sun Yat-sen University Cancer Center Guangzhou, Guangdong, China, 510060 Less << |
NCT02835404 | Cervical Cancer ... More >> Complications Less << | Phase 2 | Unknown | November 2018 | China ... More >> Daping Hospital and the Research Institute of Surgery of the Third Military Medical University Recruiting Chongqing, China Contact: Xin Lei, M.D Less << |
NCT01479504 | Nasopharyngeal Carcinoma | Phase 3 | Unknown | December 2017 | China, Guangxi ... More >> Department of Radiotherapy,the First Affiliated Hospital of Guangxi Medical University Recruiting Nanning, Guangxi, China, 530021 Contact: Wang R Sheng, M.D. 8613807806008 wrsgx@yahoo.com.cn Contact: Wu Fang, M.D. 8613978880156 96160f@163.com Principal Investigator: Wang R Sheng, M.D. Principal Investigator: Wu Fang, M.D. Less << |
NCT01265147 | Nasopharyngeal Carcinoma | Phase 2 | Unknown | December 2017 | China ... More >> Daping Hospital Not yet recruiting Chong Qing, China Contact: Zhenzhou Yang, Dr. Principal Investigator: Zhenzhou Yang, Dr. Less << |
NCT02088515 | Squamous Cell Carcinoma | Phase 4 | Completed | - | China, Hunan ... More >> Hunan Xiangya Hospital Changsha, Hunan, China China, Jiangsu Nanjing Military General Hospital Nanjing, Jiangsu, China China, Shanghai Shanghai Chest hospital Shanghai, Shanghai, China, 200000 China, Shanxi Xijing Hospital Xian, Shanxi, China Less << |
NCT02537925 | Nasopharyngeal Carcinoma | Phase 3 | Unknown | December 2016 | China, Guangxi ... More >> The third Affiliated Hospital of Guangxi Medical University Recruiting Nanning, Guangxi, China, 530021 Contact: Yan Mao, M.D. +8614795721791 zijujuan@163.com Less << |
NCT01540136 | Nasopharyngeal Carcinoma | Phase 3 | Completed | - | China, Guangdong ... More >> Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center Guangzhou, Guangdong, China, 510060 Less << |
NCT02301208 | Nasopharyngeal Carcinoma | Phase 3 | Unknown | - | - |
NCT02590133 | Nasopharyngeal Carcinoma | Phase 2 | Recruiting | December 2020 | China, Guangdong ... More >> Department of Radiation Oncology, Sun Yat-Sen University Cancer Center Recruiting Guangzhou, Guangdong, China, 510060 Contact: Yun-fei Xia, Prof. +86-13602805461 xiayf@sysucc.org.cn Contact: Chen Chen, M.D. +86-13570487011 chenchen@sysucc.org.cn Principal Investigator: Yun-fei Xia, Prof. Sub-Investigator: Chen Chen, M.D. Less << |
NCT01667211 | Uterine Cervical Cancer | Phase 2 | Unknown | December 2016 | China ... More >> Chinese Academy of Medical Sciences, Cancer Hospital, Gynecologic Oncology Recruiting Beijing, China, 100021 Contact: Rong Zhang 008613911982343 super0078888@sina.com Principal Investigator: Rong Zhang Less << |
NCT01175460 | Esophageal Cancer | Phase 1 | Completed | - | China, Zhejiang ... More >> Zhejiang Cancer Hospital Hangzhou, Zhejiang, China, 310022 Less << |
NCT02350517 | Esophageal Squamous Cell Carci... More >>noma Less << | Phase 2 | Recruiting | December 2018 | China, Guangdong ... More >> Sun Yat-sen University Cancer Center Recruiting Guangzhou, Guangdong, China, 510060 Contact: Yu-hong Li, MD, Ph D liyh@sysucc.org.cn Principal Investigator: Yu-hong Li, MD, Ph D Less << |
NCT02861690 | Esophageal Carcinoma | Phase 2 | Completed | - | China, Guangdong ... More >> Medical Oncology,Sun Yat-sen University Cancer Center Guangzhou, Guangdong, China, 510060 Less << |
NCT02643407 | Non-Small Cell Lung Cancer | Phase 3 | Unknown | December 2017 | China, Guangdong ... More >> Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences Recruiting Guangzhou, Guangdong, China, 510080 Contact: Haiyan Tu, MD +86 20 83827812 ext 50810 thoraciconcology88@163.com Contact: Yi-Long Wu, MD +86 20 83827812 ext 51221 syylwu@live.cn Principal Investigator: Yi-Long Wu, MD Sub-Investigator: Haiyan Tu, MD Less << |
NCT02964455 | Esophageal Squamous Cell Carci... More >>noma Less << | Phase 1 | Recruiting | June 2019 | China, Guangdong ... More >> Hui Liu Recruiting Guangzhou, Guangdong, China, 510060 Contact: Hui Liu, Prof. +86-020-87343031 liuhui@sysucc.org.cn Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.30mL 0.66mL 0.33mL |
16.49mL 3.30mL 1.65mL |
32.98mL 6.60mL 3.30mL |
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Dissolving Methods |
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
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