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Chemical Structure| 95734-82-0 Chemical Structure| 95734-82-0

Structure of Nedaplatin
CAS No.: 95734-82-0

Chemical Structure| 95734-82-0

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Nedaplatin is a derivative of cisplatin and DNA damage agent.

Synonyms: NSC 375101D; NSC 375101

4.5 *For Research Use Only !

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Product Details of Nedaplatin

CAS No. :95734-82-0
Formula : C2H8N2O3Pt
M.W : 303.17
SMILES Code : O=C1[O-][Pt+2]([NH3])([NH3])[O-]C1
Synonyms :
NSC 375101D; NSC 375101
MDL No. :MFCD00866374

Safety of Nedaplatin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of Nedaplatin

DNA

Isoform Comparison

Biological Activity

Target
  • DNA synthesis

In Vitro:

Cell Line
Concentration Treated Time Description References
HEK293 0.5, 1, 2, 4, 8, 10, 20 μg/mL 72 hours Evaluate the cytotoxicity of free and liposomal Nedaplatin on HEK293 cells. Results showed no significant increase in cytotoxicity with liposomal Nedaplatin. PMC7559812
WI-38 0.5, 1, 2, 4, 8, 10, 20 μg/mL 72 hours Evaluate the cytotoxicity of free and liposomal Nedaplatin on WI-38 cells. Results showed no significant increase in cytotoxicity with liposomal Nedaplatin. PMC7559812
U2OS 0.5, 1, 2, 4, 8, 10, 20 μg/mL 72 hours Evaluate the cytotoxicity of free and liposomal Nedaplatin on U2OS cells. Results showed that liposomal Nedaplatin significantly reduced cell viability at lower concentrations. PMC7559812
A549 0.5, 1, 2, 4, 8, 10, 20 μg/mL 72 hours Evaluate the cytotoxicity of free and liposomal Nedaplatin on A549 cells. Results showed that liposomal Nedaplatin significantly increased cytotoxicity at all tested concentrations. PMC7559812
MDA-MB-468 0.067 µM 24 hours Evaluate the cytotoxicity of nedaplatin on TNBC cells, results showed cytotoxicity to MDA-MB-468 cells at the highest tested dose PMC10825133
BT-549 0.15 µM 24 hours Evaluate the cytotoxicity of nedaplatin on TNBC cells, results showed high cytotoxicity to CAL-148 cells at the highest tested dose PMC10825133

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Zebrafish HCC1806 and MCF-7 cell xenograft models 25 µM 48 hours Evaluate the effect of nedaplatin combined with bortezomib on tumor regression, results showed reduced tumor volume PMC10825133

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03328234 IMRT With or Without Concurren... More >>t Chemotherapy for Esophageal Cancer Less << Phase 3 Recruiting December 31, 2022 China ... More >> Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) Recruiting Beijing, China, 100021 Contact: Xin Wang, MD    +861013311583220    beryl_wx2000@163.com Less <<
NCT03731442 Esophageal Cancer Phase 3 Recruiting October 31, 2027 China, Beijing ... More >> Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) Recruiting Beijing, Beijing, China, 100021 Contact: Zefen Xiao, MD Less <<
NCT03308552 Esophageal Neoplasms Phase 3 Recruiting August 30, 2021 China, Beijing ... More >> Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) Recruiting Beijing, Beijing, China, 100021 Contact: Zefen Xiao, MD Less <<
NCT03529279 Nasopharyngeal Carcinoma Phase 3 Not yet recruiting June 12, 2026 -
NCT03290820 Nasopharyngeal Carcinoma Phase 2 Not yet recruiting September 30, 2024 China, Guangdong ... More >> Sun Yat-sen University Cancer Center Not yet recruiting Guangzhou, Guangdong, China, 510060 Contact: Hui Chang, M.D    86-020-87343374    changhui@sysucc.org.cn    Contact: Chen Chen, M.D       chenchen@sysucc.org.cn    Principal Investigator: Yun-fei Xia, M.D Less <<
NCT03661567 Non-small Cell Lung Cancer Phase 2 Recruiting September 2021 China, Guangdong ... More >> Sun yat-sen University Cancer Center Recruiting Guangzhou, Guangdong, China, 510000 Contact: Bo Qiu, Attending    +86-020-87343031    qiubo@sysucc.org.cn    Contact: Hui Liu, Professor Less <<
NCT03663764 Thymoma and Thymic Carcinoma Phase 2 Recruiting August 2023 China, Guangdong ... More >> Sun yat-sen University Cancer Center Recruiting Guangzhou, Guangdong, China, 510000 Contact: Bo Qiu, Attending    +86-020-87343031    qiubo@sysucc.org.cn    Contact: Hui Liu, Professor Less <<
NCT03344068 Nasopharyngeal Carcinoma ... More >> Nutritional Support Less << Phase 2 Phase 3 Not yet recruiting March 31, 2021 China, Guangdong ... More >> Department of Radiation Oncology, Sun Yat-Sen University Cancer Center Guangzhou, Guangdong, China, 510060 Less <<
NCT02721563 Esophageal Neoplasms Phase 2 Recruiting December 2018 China, Shandong ... More >> Qianfoshan Hospital of Shandong Recruiting Jinan, Shandong, China, 250117 Contact: Jiandong Zhang    13583123486       Qilu Hospital of Shandong University Not yet recruiting Jinan, Shandong, China, 250117 Contact: Yufeng Cheng    13869199969       Shandong Cancer Hospital and Institute Recruiting Jinan, Shandong, China, 250117 Contact: Jinming Yu    8653167626891       Jining NO.1 People's Hospital Recruiting Jining, Shandong, China, 250117 Contact: Peipei Wu    15853770581       Liaocheng People 's Hospital Recruiting Liaocheng, Shandong, China Contact: Mingjun Li, MD          Qingdao Center Medical Group Recruiting Qingdao, Shandong, China, 250117 Contact: Xuezhen Ma    18660221959       Rizhao City People 's Hospital Recruiting Rizhao, Shandong, China Contact: yufeng li          Fei Cheng People's Hospital Recruiting Tai'an, Shandong, China, 250117 Contact: Wenyuan Zhao    13518688689       An Qiu People's Hospital Recruiting Weifang, Shandong, China, 250117 Contact: Chuandong Wang    15605368369       The Fourth People's Hospitalof Zibo Recruiting Zibo, Shandong, China, 250117 Contact: Qiang Zhang    13345221111 Less <<
NCT03659578 Non-small Cell Lung Cancer Phase 2 Recruiting September 2020 China, Guangdong ... More >> Sun yat-sen University Cancer Center Recruiting Guangzhou, Guangdong, China, 510000 Contact: Bo Qiu, Attending    +86-020-87343031    qiubo@sysucc.org.cn    Contact: Hui Liu, Professor Less <<
NCT02721576 Esophageal Neoplasms Phase 2 Recruiting December 2018 China, Shandong ... More >> Qianfoshan Hospital of Shandong Recruiting Jinan, Shandong, China, 250117 Contact: Jiandong Zhang    13583123486       Shandong Cancer Hospital and Institute Recruiting Jinan, Shandong, China, 250117 Contact: Jinming Yu    8653167626891       Jining NO.1 People's Hospital Recruiting Jining, Shandong, China, 250117 Contact: Peipei Wu    15853770581       Liaocheng People Hospital Recruiting Liaocheng, Shandong, China Contact: mingjun Li          Qingdao Center Medical Group Recruiting Qingdao, Shandong, China, 250117 Contact: Xuezhen Ma    18660221959       Rizhao City People 's Hospital Recruiting Rizhao, Shandong, China Contact: Yufeng Li          Fei Cheng People's Hospital Recruiting Tai'an, Shandong, China, 250117 Contact    13518688689       An Qiu People's Hospital Recruiting Weifang, Shandong, China, 250117 Contact: Chuandong Wang    15605368369       The Fourth People's Hospitalof Zibo Recruiting Zibo, Shandong, China, 250117 Contact: Qiang Zhang    13345221111 Less <<
NCT03673657 Local Advanced Non-small Cell ... More >>Lung Cancer Less << Phase 2 Recruiting August 2022 China, Guangdong ... More >> Sun yat-sen University Cancer Center Recruiting Guangzhou, Guangdong, China, 510000 Contact: Bo Qiu, Attending    +86-020-87343031    qiubo@sysucc.org.cn    Contact: Hui Liu, Professor Less <<
NCT02721550 Esophageal Neoplasms Phase 2 Recruiting December 2018 China, Shandong ... More >> Qianfoshan Hospital of Shandong Recruiting Jinan, Shandong, China, 250117 Contact: Jiandong Zhang    13583123486       Shandong Cancer Hospital and Institute Recruiting Jinan, Shandong, China, 250117 Contact: Jinming Yu          Jining NO.1 People's Hospital Recruiting Jining, Shandong, China, 250117 Contact: Peipei Wu    15853770581       Liaocheng People Hospital Recruiting Liaocheng, Shandong, China Contact: Mingjun Li          Qingdao Center Medical Group Recruiting Qingdao, Shandong, China, 250117 Contact: Xuezhen Ma          Rizhao City People 's Hospital Recruiting Rizhao, Shandong, China Contact: Yufeng Li          Fei Cheng People's Hospital Recruiting Tai'an, Shandong, China, 250117 Contact: Wenyuan Zhao    13518688689       An Qiu People's Hospital Recruiting Weifang, Shandong, China, 250117 Contact: Chuandong Wang    15605368369       The Fourth People's Hospitalof Zibo Recruiting Zibo, Shandong, China, 250117 Contact: Qiang Zhang    13345221111 Less <<
NCT01137123 Thoracic Esophageal Squamous C... More >>ell Carcinoma Less << Phase 3 Recruiting December 2020 China, Guangdong ... More >> Sun Yat-sen Uniersity Cancer Center Recruiting GuangZhou, Guangdong, China, 510060 Contact: Peng Lin, Professor    +86-20-87343314    linpeng@sysucc.org.cn    Contact: Jun Zeng    +86-20-87343736    xingrp@sysucc.org.cn    Principal Investigator: Peng Lin, Professor Less <<
NCT02573506 Non-small Cell Lung Cancer Phase 2 Active, not recruiting July 2020 China, Guangdong ... More >> Hui Liu Guangzhou, Guangdong, China, 510000 Less <<
NCT02430974 Carcinoma, Non-Small-Cell Lung Phase 2 Unknown January 2018 -
NCT02777788 Cancer Phase 2 Phase 3 Active, not recruiting December 2019 -
NCT02858206 Esophageal Neoplasms Phase 2 Recruiting November 2021 China, Beijing ... More >> Zefen Xiao Recruiting Beijing, Beijing, China, 100021 Contact: Zefen Xiao, MD    8610-87787643    xiaozefen@sina.com    Contact: Wei Deng, MD    +8618813019080    sherrydw@126.com Less <<
NCT02279134 Esophageal Neoplasms ... More >> Esophageal Cancer Less << Phase 2 Phase 3 Recruiting October 2022 China, Beijing ... More >> Cancer Institute and Hospital, Chinese Academy of Medical Science Recruiting Beijing, Beijing, China, 100021 Contact: Zefen Xiao, MD    8610-87787463    xiaozefen@sina.com    Contact: Shufei Yu, MD    86-15911070901    sophie314@yeah.net Less <<
NCT02429622 Esophageal Neoplasms Phase 1 Phase 2 Completed - China, Beijing ... More >> Zefen Xiao Beijing, Beijing, China, 100021 Less <<
NCT03649945 Esophageal Cancer Phase 2 Not yet recruiting May 2021 -
NCT01712919 Nasopharyngeal Carcinoma Phase 1 Phase 2 Completed - China, Jiangsu ... More >> Jiangsu Cancer Hospital Nanjing, Jiangsu, China, 210009 Less <<
NCT03006575 Non-small Cell Lung Cancer Phase 2 Recruiting July 2021 China, Guangdong ... More >> Hui Liu Recruiting Guangzhou, Guangdong, China, 510000 Contact: Hui Liu, professor    +86-020-87343031    liuhui@sysucc.org.cn Less <<
NCT01694576 Nasopharyngeal Carcinoma Phase 2 Terminated(slow patient enroll... More >>ment) Less << October 2015 China, Jiangsu ... More >> Jiangsu Cancer Hospital Nanjing, Jiangsu, China, 210009 Less <<
NCT01201044 Non-small Cell Lung Cancer Not Applicable Unknown December 2012 China ... More >> The 3rd Affiliated Hospital of the 3rd Military Hospital Recruiting Chongqing, China Contact: Yi Li    +86-13452081471       Sub-Investigator: YI LI Less <<
NCT02364804 - Unknown September 2015 Japan ... More >> Shiga University of Medical Science Hospital Otsu, Shiga, Japan, 520-2192 Less <<
NCT03603756 Esophageal Squamous Cell Carci... More >>noma Less << Phase 2 Recruiting March 28, 2021 China ... More >> Jing Huang Recruiting Beijing, China Contact: Jing Huang, MD Less <<
NCT01040312 - Unknown March 2014 Japan ... More >> Department of Obstetrics and Gynecology, National Defense Medical College Hospital Tokorozawa, Saitama, Japan, 359-8513 Less <<
NCT00197444 Esophageal Cancer ... More >> Squamous Cell Carcinoma Less << Phase 2 Completed - Japan ... More >> First Department of Medicine, Hamamatsu University School of Medicine Hamamatsu, Japan, 431-3192 Less <<
NCT01735747 Central Nervous System Tumors Phase 2 Unknown November 2013 China, Shandong ... More >> Neurosurgery, Shandong Cancer Hospital and Institute Jinan, Shandong, China, 250117 Less <<
NCT02789189 Recurrent and Metastatic Nasop... More >>haryngeal Carcinoma Less << Phase 2 Not yet recruiting - -
NCT03503136 Nasopharyngeal Carcinoma Phase 3 Not yet recruiting June 2026 China, Guangdong ... More >> Sun Yat-sen University Cancer Center Guangzhou, Guangdong, China, 510060 Less <<
NCT02835404 Cervical Cancer ... More >> Complications Less << Phase 2 Unknown November 2018 China ... More >> Daping Hospital and the Research Institute of Surgery of the Third Military Medical University Recruiting Chongqing, China Contact: Xin Lei, M.D Less <<
NCT01479504 Nasopharyngeal Carcinoma Phase 3 Unknown December 2017 China, Guangxi ... More >> Department of Radiotherapy,the First Affiliated Hospital of Guangxi Medical University Recruiting Nanning, Guangxi, China, 530021 Contact: Wang R Sheng, M.D.    8613807806008    wrsgx@yahoo.com.cn    Contact: Wu Fang, M.D.    8613978880156    96160f@163.com    Principal Investigator: Wang R Sheng, M.D.          Principal Investigator: Wu Fang, M.D. Less <<
NCT01265147 Nasopharyngeal Carcinoma Phase 2 Unknown December 2017 China ... More >> Daping Hospital Not yet recruiting Chong Qing, China Contact: Zhenzhou Yang, Dr.          Principal Investigator: Zhenzhou Yang, Dr. Less <<
NCT02088515 Squamous Cell Carcinoma Phase 4 Completed - China, Hunan ... More >> Hunan Xiangya Hospital Changsha, Hunan, China China, Jiangsu Nanjing Military General Hospital Nanjing, Jiangsu, China China, Shanghai Shanghai Chest hospital Shanghai, Shanghai, China, 200000 China, Shanxi Xijing Hospital Xian, Shanxi, China Less <<
NCT02537925 Nasopharyngeal Carcinoma Phase 3 Unknown December 2016 China, Guangxi ... More >> The third Affiliated Hospital of Guangxi Medical University Recruiting Nanning, Guangxi, China, 530021 Contact: Yan Mao, M.D.    +8614795721791    zijujuan@163.com Less <<
NCT01540136 Nasopharyngeal Carcinoma Phase 3 Completed - China, Guangdong ... More >> Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center Guangzhou, Guangdong, China, 510060 Less <<
NCT02301208 Nasopharyngeal Carcinoma Phase 3 Unknown - -
NCT02590133 Nasopharyngeal Carcinoma Phase 2 Recruiting December 2020 China, Guangdong ... More >> Department of Radiation Oncology, Sun Yat-Sen University Cancer Center Recruiting Guangzhou, Guangdong, China, 510060 Contact: Yun-fei Xia, Prof.    +86-13602805461    xiayf@sysucc.org.cn    Contact: Chen Chen, M.D.    +86-13570487011    chenchen@sysucc.org.cn    Principal Investigator: Yun-fei Xia, Prof.          Sub-Investigator: Chen Chen, M.D. Less <<
NCT01667211 Uterine Cervical Cancer Phase 2 Unknown December 2016 China ... More >> Chinese Academy of Medical Sciences, Cancer Hospital, Gynecologic Oncology Recruiting Beijing, China, 100021 Contact: Rong Zhang    008613911982343    super0078888@sina.com    Principal Investigator: Rong Zhang Less <<
NCT01175460 Esophageal Cancer Phase 1 Completed - China, Zhejiang ... More >> Zhejiang Cancer Hospital Hangzhou, Zhejiang, China, 310022 Less <<
NCT02350517 Esophageal Squamous Cell Carci... More >>noma Less << Phase 2 Recruiting December 2018 China, Guangdong ... More >> Sun Yat-sen University Cancer Center Recruiting Guangzhou, Guangdong, China, 510060 Contact: Yu-hong Li, MD, Ph D       liyh@sysucc.org.cn    Principal Investigator: Yu-hong Li, MD, Ph D Less <<
NCT02861690 Esophageal Carcinoma Phase 2 Completed - China, Guangdong ... More >> Medical Oncology,Sun Yat-sen University Cancer Center Guangzhou, Guangdong, China, 510060 Less <<
NCT02643407 Non-Small Cell Lung Cancer Phase 3 Unknown December 2017 China, Guangdong ... More >> Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences Recruiting Guangzhou, Guangdong, China, 510080 Contact: Haiyan Tu, MD    +86 20 83827812 ext 50810    thoraciconcology88@163.com    Contact: Yi-Long Wu, MD    +86 20 83827812 ext 51221    syylwu@live.cn    Principal Investigator: Yi-Long Wu, MD          Sub-Investigator: Haiyan Tu, MD Less <<
NCT02964455 Esophageal Squamous Cell Carci... More >>noma Less << Phase 1 Recruiting June 2019 China, Guangdong ... More >> Hui Liu Recruiting Guangzhou, Guangdong, China, 510060 Contact: Hui Liu, Prof.    +86-020-87343031    liuhui@sysucc.org.cn Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.30mL

0.66mL

0.33mL

16.49mL

3.30mL

1.65mL

32.98mL

6.60mL

3.30mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

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