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[ CAS No. 957346-57-5 ] {[proInfo.proName]}

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Chemical Structure| 957346-57-5
Chemical Structure| 957346-57-5
Structure of 957346-57-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 957346-57-5 ]

CAS No. :957346-57-5 MDL No. :MFCD17215213
Formula : C13H17BFNO3 Boiling Point : -
Linear Structure Formula :- InChI Key :AUQWDALPXJFOBB-UHFFFAOYSA-N
M.W : 265.09 Pubchem ID :59023064
Synonyms :

Safety of [ 957346-57-5 ]

Signal Word:Warning Class:
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:
Hazard Statements:H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 957346-57-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 957346-57-5 ]

[ 957346-57-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 292621-45-5 ]
  • [ 73183-34-3 ]
  • [ 957346-57-5 ]
YieldReaction ConditionsOperation in experiment
100% With potassium acetate In 1,4-dioxane at 90℃; for 0.35h; Microwave irradiation; E.1 E.1 2-Fluoro-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)benzamide[0360] Pd(dppf)Cl2 (21 mg, 0.028 mmol, 0.03 eq), potassium acetate (277 mg, 1.03 mmol, 2.82 mmol, 3 eq), 4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(l,3,2-dioxaborolane) (263 mg, 1.1 eq), and 4-bromo-2- fluorobenzamide (205 mg, 0.94 mmol, 1.0 eq) are suspended in anhydrous dioxane (2 mL) in a 5-mL microwave vial and the mixture is purged with nitrogen for 1 min. The resulting slurry is heated for 20 min at 90 0C in a microwave (Biotage Initiator, Absorption high). DCM (2 mL) is added to the dark brown reaction mixture and the resulting suspension is filtered. The precipitate collected on the frit is washed with DCM (2 x 5 mL) and the solid residue remaining in the microwave tube is washed with DCM (2 x 2 mL). The DCM washes and filtrates are combined. Celite (1.5 g) is added to the organic extracts and the solvent is evaporated on a rotary evaporator to provide a free-flowing powder. The Celite/compound mixture was loaded onto a prepacked silica column (10 g of silica) and the column eluted with 1 :1 hexane/ethyl acetate to provide the crude 2-fluoro-4-(4,4,5, 5-tetramethyl-l, 3,2- dioxaborolan-2-yl)benzamide (307 mg, 124% recovery). The product was used in the next step without further purification. LCMS Purity: 78% by UV 254 nm detection); LCMS-ESI (m/z): calcd for Ci3H17BFNO3, 265.1; [M+H]+ found, 266.1.
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane
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