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[ CAS No. 96036-03-2 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 96036-03-2
Chemical Structure| 96036-03-2
Structure of 96036-03-2 *Storage: {[proInfo.prStorage]}

Quality Control of [ 96036-03-2 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 96036-03-2 ]

SDS

Product Details of [ 96036-03-2 ]

CAS No. :96036-03-2MDL No. :MFCD00864966
Formula :C17H25N3O5SBoiling Point :627.4°C at 760 mmHg
Linear Structure Formula :-InChI Key :N/A
M.W :383.46Pubchem ID :-
Synonyms :

1. Meropenem

Computed Properties of [ 96036-03-2 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 96036-03-2 ]

Signal Word:WarningClassN/A
Precautionary Statements:P305+P351+P338UN#:N/A
Hazard Statements:H315-H319Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 96036-03-2 ]

  • Downstream synthetic route of [ 96036-03-2 ]

[ 96036-03-2 ] Synthesis Path-Downstream   1~10

  • 4
  • [ 96036-03-2 ]
  • NaH(13)CO3 [ No CAS ]
  • meropenem-CO2 adduct [ No CAS ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran; water; at 0 - 20℃;Activated carbon;Purification / work up; EXAMPLE 1; Crude product of (4R,5S,6S)-3-[[(3S,5S)-5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (content, 95%; 200 g) was dissolved in water (about 20 L) at 20 C., activated carbon (10 g) was added thereto, and stirred for about one hour. After removal of the activated carbon by filtration, the filtrate was washed with water; the aqueous solution was concentrated by the use of reverse osmosis condensing apparatus under a pressure of about 120 psi at 10-20 C. The resulting condensate (6.7 L) was cooled to 0 to 10 C. The seed (Meropenem with 98% content; 1 g) was added to the resulting condensate, and then a (20.1 L) tetrahydrofuran was added thereto at 0-10 C., followed by stirring for 6 hour at 0-5 C. The precipitated crystals were collected by filtration, washed with acetone and dried at 30 C. for 3 hours to give 180.5 g of the crystalline carbapenem compound (compound A in a crystalline form B) of the present invention.
With sodium dithionite; ethylenediaminetetraacetic acid; In methanol; water; acetone; at 3 - 13℃;Purification / work up; Meropenem trihydrate non-sterile (50 gm) was added in cold methanol and stirred to get clear solution. To this clear solution, EDTA (0.25 gm), sodium hydro sulphite followed by ENO carbon was added and it is filtered to remove the carbon. The carbon bed was washed with chilled methanol (25 ml). The solution was filtered through 0.2 micron filter paper. To filtrate, water was added at 10 -13C followed by the addition of acetone. The reaction mass was further cooled to 3-5C, the product obtained was filtered and washed with chilled mixture of Acetone and water (3: 1) to yield Meropenem trihydrate in pure form.Yield: 95%; RCT < 60 sec
  • 6
  • [ 96036-03-2 ]
  • Meropenoic acid [ No CAS ]
  • 7
  • [ 60-23-1 ]
  • [ 96036-03-2 ]
  • (4R,5S)-3-((3S,5S)-5-Dimethylcarbamoyl-pyrrolidin-3-ylsulfanyl)-5-[(1R,2R)-2-hydroxy-1-(2-mercapto-ethylcarbamoyl)-propyl]-4-methyl-4,5-dihydro-3H-pyrrole-2-carboxylic acid [ No CAS ]
  • 8
  • [ 79178-11-3 ]
  • [ 96036-03-2 ]
  • (4R,5S)-3-((3S,5S)-5-Dimethylcarbamoyl-pyrrolidin-3-ylsulfanyl)-5-[(1R,2R)-2-hydroxy-1-((R)-1-isopropoxycarbonyl-2-mercapto-ethylcarbamoyl)-propyl]-4-methyl-4,5-dihydro-3H-pyrrole-2-carboxylic acid [ No CAS ]
  • 9
  • [ 70-18-8 ]
  • [ 96036-03-2 ]
  • (4R,5S)-5-((1R,2R)-1-{(S)-1-Carboxy-3-[(R)-1-(carboxymethyl-carbamoyl)-2-mercapto-ethylcarbamoyl]-propylcarbamoyl}-2-hydroxy-propyl)-3-((3S,5S)-5-dimethylcarbamoyl-pyrrolidin-3-ylsulfanyl)-4-methyl-4,5-dihydro-3H-pyrrole-2-carboxylic acid [ No CAS ]
  • 10
  • [ 19246-18-5 ]
  • [ 96036-03-2 ]
  • (4R,5S)-5-{(1R,2R)-1-[(R)-1-(Carboxymethyl-carbamoyl)-2-mercapto-ethylcarbamoyl]-2-hydroxy-propyl}-3-((3S,5S)-5-dimethylcarbamoyl-pyrrolidin-3-ylsulfanyl)-4-methyl-4,5-dihydro-3H-pyrrole-2-carboxylic acid [ No CAS ]
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