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Chemical Structure| 97240-79-4 Chemical Structure| 97240-79-4

Structure of Topiramate
CAS No.: 97240-79-4

Chemical Structure| 97240-79-4

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Topiramate is a selective GluK1 kainate receptors (GluR5) antagonist with IC50 value of 0.46 μM which can act as a positive allosteric modulator of GABAA receptor-mediated currents, inhibit Nav channels and L-type Ca2+ channels.

Synonyms: McN 4853; RWJ 17021; Topax

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Product Details of Topiramate

CAS No. :97240-79-4
Formula : C12H21NO8S
M.W : 339.36
SMILES Code : CC1(O[C@H]([C@@H](CO[C@@]2(COS(=O)(N)=O)O3)O1)[C@@H]2OC3(C)C)C
Synonyms :
McN 4853; RWJ 17021; Topax
MDL No. :MFCD00865320
InChI Key :KJADKKWYZYXHBB-XBWDGYHZSA-N
Pubchem ID :5284627

Safety of Topiramate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335-H351-H361
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Topiramate

GPCR

Isoform Comparison

Biological Activity

Target
  • Carbonic Anhydrase

In Vitro:

Cell Line
Concentration Treated Time Description References
Mouse cortical layer II/III pyramidal neurons 50 μmol/L 10 minutes To evaluate the effect of SAS on eIPSCs, results showed that SAS reversibly decreased eIPSC amplitude and prolonged the τslow decay kinetics PMC6771750
C2C12 myotubes 1 or 100 μM 45 minutes To assess the effect of topiramate on glucose uptake and insulin signaling. Results showed that topiramate did not affect basal or insulin-stimulated glucose uptake. PMC3799603

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice Wild-type and familial hemiplegic migraine type 1 knock-in mice Orogastric gavage 80 mg/kg/d Once daily for 7 weeks Chronic topiramate treatment reduced susceptibility to KCl- or electrical stimulation-induced spreading depressions as well as ischemic depolarizations, and improved tissue and neurological outcomes PMC4276468
DBA/2 mice High impulsivity mouse model Oral 12.5, 25, 50 mg/kg Acute administration: single dose 60 min before testing; Chronic administration: twice daily for 27 days Evaluate the effects of topiramate on impulsive behaviors. Acute administration reduced motor impulsivity, chronic administration reduced cognitive impulsivity. PMC3448922
Mice No specific model mentioned Intraperitoneal injection 0.3, 1, 3, 10, 30, 100 mg/kg Twice daily for 5 days Investigate the effect of topiramate on glutamine synthetase activity in mouse brain. Single doses had no effect, but repeated administration dose-dependently reduced enzyme activity. PMC1565942
Rats ISDN-induced acute and chronic migraine model Intravenous injection 30 mg/kg Single injection Topiramate reversed ISDN-induced chronic mechanical allodynia, with effects comparable to those of mambalgin-1 and amiloride PMC6177611
C57Bl/6J mice High-fat diet-induced insulin resistance model Oral (mixed in high-fat diet) 0.12% (w/w) 6 weeks continuously To assess the effect of topiramate on insulin sensitivity. Results showed that topiramate improved insulin sensitivity and increased glucose uptake in heart, skeletal muscle, and adipose tissue. PMC3799603
C57BL/6J mice Cisplatin or oxaliplatin-induced neuropathy model Intraperitoneal injection 50 mg/kg Single dose, assessed 24 hours after neuropathy induction To evaluate the analgesic effects of topiramate on cisplatin or oxaliplatin-induced neuropathy. Results showed that topiramate lacked significant anti-allodynic effects in both models. PMC4165414

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00598923 Traumatic Brain Injury ... More >> Epilepsy Less << Early Phase 1 Terminated(End of funding and ... More >>low enrollment) Less << - -
NCT00210574 Epilepsy, Absence Phase 2 Completed - -
NCT00231556 Epilepsy Seiz... More >>ures Epilepsies, Partial Epilepsy, Generalized Epilepsy, Tonic-Clonic Less << Phase 3 Completed - -
NCT00448825 Alcohol Dependence ... More >> Cocaine Dependence Less << Phase 3 Unknown June 2013 United States, Virginia ... More >> University of Virginia Center for Addiction Research and Education Recruiting Charlottesville, Virginia, United States, 22911 Contact: Mindy Borszich    888-882-2345    mcb3x@virginia.edu    Contact: Eva Jenkins-Mendoza    (434)243-0562    emj9c@virginia.edu    Principal Investigator: Bankole Johnson, DSc,MD,PhD          Sub-Investigator: Nassima Ait-Daoud, MD          University of Virginia Center for Addiction Research and Education Recruiting Richmond, Virginia, United States, 23294 Contact: Mindy Borszich    888-882-2345    mcb3x@virginia.edu    Contact: Eva Jenkins-Mendoza    (434)243-0562    emj9c@virginia.edu    Principal Investigator: Bankole Johnson, DSc,MD,PhD          Sub-Investigator: Nassima Ait-Daoud, MD Less <<
NCT03176953 PTSD and Alcohol Use Disorder Phase 2 Phase 3 Recruiting October 31, 2021 United States, California ... More >> VA San Diego Healthcare System, San Diego, CA Recruiting San Diego, California, United States, 92161 Contact: Sonya B Norman, PhD    858-552-8585 ext 5198    Sonya.Norman@va.gov    Principal Investigator: Sonya B. Norman, PhD Less <<
NCT00153699 Glaucoma, Angle-Closure PHASE4 UNKNOWN 2025-07-07 Hong Kong Eye Hospital, Kowloo... More >>n, Hong Kong|Prince of Wales Hospital, Shatin, Hong Kong Less <<
NCT00249691 Cocaine-Related Disorders Phase 3 Unknown October 2012 United States, Virginia ... More >> UVA CARE Charlottesville, Virginia, United States, 22911 UVA CARE Richmond Richmond, Virginia, United States, 23294 Less <<
NCT00182520 Obsessive Compulsive Disorder Phase 4 Recruiting April 2019 Canada, Ontario ... More >> MacAnxiety Research Centre Recruiting Hamilton, Ontario, Canada, L8S 1B7 Contact: Beth Patterson, BScN, BEd    905-921-7644    bpatter@mcmaster.ca    Sub-Investigator: Catherine Mancini, MD, FRCPC          Sub-Investigator: Steve Collins, MB, FRCPC          Sub-Investigator: Jonathan Oakman, PhD          Principal Investigator: Michael Van Ameringen, MD, FRCPC Less <<
NCT00725920 Posttraumatic Stress Disorder Phase 4 Completed - Brazil ... More >> Federal University of Sao Paulo Sao Paulo, Brazil, 04023-061 Less <<
NCT01182766 Alcohol Dependence ... More >> Nicotine Dependence Less << Phase 2 Phase 3 Recruiting December 2017 United States, California ... More >> University of California, San Diego Active, not recruiting La Jolla, California, United States, 92093 United States, Texas University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: O'Neak Henigan    713-745-4472    OCHenigan@manderson.org    Principal Investigator: Paul M Cinciripini, Ph.D.          United States, Virginia University of Virginia Center for Addiction Research & Education Active, not recruiting Charlottesville, Virginia, United States, 22911 University of Virginia Center for Addiction Research & Education Active, not recruiting Richmond, Virginia, United States, 23294 Less <<
NCT00211744 Obsessive-compulsive Disorder Phase 4 Completed - United States, New York ... More >> Mount Sinai School of Medicine New York, New York, United States, 10029 Less <<
NCT00725920 - Completed - -
NCT00182455 Social Phobia Phase 4 Recruiting March 2019 Canada, Ontario ... More >> MacAnxiety Research Centre Recruiting Hamilton, Ontario, Canada, L8S 1B7 Contact: Beth Patterson, BScN, BEd    905-921-7644    bpatter@mcmaster.ca    Principal Investigator: Michael Van Ameringen, MD, FRCPC          Sub-Investigator: Steve Collins, MBChB, FRCPC Less <<
NCT00794313 Parkinson's Disease Not Applicable Terminated(Funding Ended) - United States, Oregon ... More >> Oregon Health & Science University Portland, Oregon, United States, 97239 Less <<
NCT00370188 Gambling PHASE2 WITHDRAWN - Centre for Addiction and Menta... More >>l Health, Toronto, Ontario, M5S 2S1, Canada Less <<
NCT00794313 - Terminated(Funding Ended) - -
NCT00421603 - Completed - -
NCT00297349 Seizures|Epilepsy COMPLETED 2025-06-05 -
NCT00233012 Seizures PHASE1 COMPLETED 2025-10-07 -
NCT00421603 Cocaine Dependence Phase 2 Completed - United States, New York ... More >> STARS New York, New York, United States, 10032 Less <<
NCT00463775 Alcohol Dependence|Borderline ... More >>Personality Disorder Less << PHASE3 WITHDRAWN 2025-05-09 -
NCT00216567 Epilepsy, Rolandic Phase 4 Completed - -
NCT01843699 Pathological Gambling Phase 2 Completed - Brazil ... More >> Instituto de Psiquiatria da Universidade de São Paulo São Paulo, Brazil, 05403-010 Less <<
NCT00905164 - Completed - -
NCT00266604 Epilepsy|Seizures|Epilepsies, ... More >>Partial|Epilepsy, Generalized|Seizures, Tonic-Clonic Less << PHASE4 COMPLETED 2025-06-07 -
NCT00905164 Healthy Phase 1 Completed - Canada, Quebec ... More >> Anapharm Inc. Sainte-Foy, Quebec, Canada, G1V 2K8 Less <<
NCT01749215 Alcohol Dependence ... More >> Posttraumatic Stress Disorder (PTSD) Less << Phase 4 Recruiting December 2018 United States, California ... More >> San Francisco VA Medical Center Recruiting San Francisco, California, United States, 94121 Principal Investigator: Steven L. Batki, MD Less <<
NCT00231673 Diabetic Neuropathies|Diabetes... More >> Mellitus, Type 2|Polyneuropathies Less << PHASE2 COMPLETED 2025-01-03 -
NCT00685178 - Completed - -
NCT00956696 - Unknown June 2013 Hong Kong ... More >> Prince of Wales Hospital Recruiting Hong Kong, Hong Kong Less <<
NCT00939705 - Completed - -
NCT00939705 Healthy Phase 1 Completed - United States, Missouri ... More >> Gateway Medical Research, Inc. St, Charles, Missouri, United States Less <<
NCT01836874 - Completed - -
NCT00755716 Tobacco Dependence Phase 3 Completed - United States, Connecticut ... More >> University of Connecticut Halth Center Farmington, Connecticut, United States, 06030 Less <<
NCT00755716 - Completed - -
NCT02098941 - Unknown December 2014 Korea, Republic of ... More >> Seoul National University Hospital Recruiting Seoul, Korea, Republic of Contact: Sang kun Lee, MD,PhD       sangkun2923@gmail.com    Contact: Jung-won Shin, MD       limitsum@gmail.com    Principal Investigator: Sang kun Lee, MD, PhD Less <<
NCT00986128 Bipolar Disorder Phase 1 Completed - -
NCT00685178 Cocaine Dependence Phase 2 Completed - United States, Maryland ... More >> Behavioral Pharmacology Research Unit Baltimore, Maryland, United States, 21224 Less <<
NCT03712917 Migraine Not Applicable Completed - Turkey ... More >> Ataturk University Resarch Hospital Erzurum, Turkey, 25000 Less <<
NCT03280342 Migraine Head... More >>ache Less << Phase 2 Terminated(Sponsor terminated ... More >>study) Less << - United States, Minnesota ... More >> University of Minnesota Minneapolis, Minnesota, United States, 55455 Prism Research Saint Paul, Minnesota, United States, 55114 Less <<
NCT00297336 Migraine Disorders COMPLETED 2025-02-07 -
NCT00216606 Migraine Phase 3 Completed - -
NCT02371889 Alcoholism Phase 2 Recruiting January 2021 United States, Pennsylvania ... More >> Corporal Michael J. Crescenz VA Medical Center Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Timothy S Pond, MPH    215-746-1959    timpond@pennmedicine.upenn.edu    Principal Investigator: Henry Kranzler, MD          University of Pennsylvania Treatment Research Center Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Timothy S. Pond, M.P.H.    215-746-1959    timpond@pennmedicine.upenn.edu    Principal Investigator: Henry R. Kranzler, M.D. Less <<
NCT00345371 Methamphetamine Phase 2 Completed - United States, California ... More >> Matrix Institute on Addictions Costa Mesa, California, United States, 92627 South Bay Treatment Center San Diego, California, United States, 92105 Torrance Site Torrance, California, United States, 90502 United States, Hawaii John A. Burns School of Medicine Honolulu, Hawaii, United States, 96813 United States, Iowa Powell Chemical Dependency Center Des Moines, Iowa, United States, 50316 United States, Missouri University of Missouri - Kansas City Kansas City, Missouri, United States, 64108 United States, Utah Salt Lake City VA Medical Center Salt Lake City, Utah, United States, 84148 United States, Virginia UVA CARE Charlottesville, Virginia, United States, 22911 Less <<
NCT00345371 - Completed - -
NCT00753493 Epilepsy Migr... More >>aines Less << Phase 1 Completed - United States, Minnesota ... More >> University of Minnesota Minneapolis, Minnesota, United States, 55455 Less <<
NCT01970566 Obesity Diabe... More >>tes Mellitus Less << Not Applicable Withdrawn(The project was not ... More >>announced to the field and it was not funded.) Less << November 2017 United States, Illinois ... More >> Captain James A. Lovell Federal Health Care Center, North Chicago, IL North Chicago, Illinois, United States, 60064 Less <<
NCT01700387 Chronic Migraine Phase 4 Completed - United States, Missouri ... More >> Clinvest/A Division of Banyan Group, Inc. Springfield, Missouri, United States, 65807 Less <<
NCT01060111 Migraine Phase 4 Completed - Korea, Republic of ... More >> Busan, Korea, Republic of Daegu, Korea, Republic of Kwangjoo, Korea, Republic of Kyunggi-Do, Korea, Republic of Seoul, Korea, Republic of Uijeongbu, Korea, Republic of Less <<
NCT01060111 - Completed - -
NCT00216619 Migraine Phase 3 Completed - -
NCT01241019 Hypoxic Ischemic Encephalopath... More >>y Less << Phase 2 Completed - Italy ... More >> Neonatal Intensive Care Unit - Azienda Ospedaliero-Universitaria Meyer Florence, Italy, I-50139 Neonatal Intensive Care Unit - Azienda Ospedaliero-Universitaria Pisana Pisa, Italy, I-56100 Less <<
NCT00732108 Migraine Head... More >>ache Dizziness Less << Not Applicable Withdrawn(No subjects enrolled... More >>) Less << - United States, California ... More >> University of California, San Francisco San Francisco, California, United States, 94143 Less <<
NCT00223626 Cocaine-Related Disorders PHASE2 COMPLETED 2025-12-10 University of Virginia CARE Ce... More >>nter for Addiction Research & Education, Charlottesville, Virginia, 22911, United States|UVA CARE Richmond, Richmond, Virginia, 23294, United States Less <<
NCT01700387 - Completed - -
NCT00167245 Alcoholism Co... More >>caine Dependence Less << Phase 2 Completed - United States, Pennsylvania ... More >> University of Pennsylvania, Treatment Research Center Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00939692 Healthy PHASE1 COMPLETED 2025-04-07 Gateway Medical Research, Inc.... More >>, St, Charles, Missouri, 63301, United States Less <<
NCT00167245 - Completed - -
NCT00988481 Bulimia Nervosa PHASE4 WITHDRAWN 2025-09-10 Neuropsychiatric Research Inst... More >>itute (NRI), Fargo, North Dakota, 58103, United States Less <<
NCT00939692 Healthy PHASE1 COMPLETED 2025-04-07 Gateway Medical Research, Inc.... More >>, St, Charles, Missouri, 63301, United States Less <<
NCT01384279 Obesity Not Applicable Completed - Taiwan ... More >> Beitou Armed Forces Hospital Taipei, Taiwan, 11243 Less <<
NCT01834404 Obesity Phase 4 Completed - United States, Minnesota ... More >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Less <<
NCT00986336 Bipolar Disorder Phase 1 Completed - -
NCT00550394 - Completed - -
NCT00550394 Bipolar Disorder ... More >> Alcohol Abuse Less << Phase 4 Completed - United States, Ohio ... More >> University of Cincinnati Medical Center Cincinnati, Ohio, United States, 45227 Less <<
NCT01627860 Epilepsy Phase 4 Completed - -
NCT01627860 - Completed - -
NCT01191086 - Completed - -
NCT01191086 Epilepsy Phase 3 Completed - -
NCT01834404 - Completed - -
NCT03479086 Alcohol Dependence Phase 3 Recruiting November 1, 2020 Australia, New South Wales ... More >> Drug Health Services, Royal Prince Alfred Hospital Recruiting Sydney, New South Wales, Australia, 2050 Contact: Kirsten C Morley, PhD    +61295153636    kirsten.morley@sydney.edu.au    Contact: Central Intake    95157611    sydneyalcoholtreatmentgroup@gmail.com    Principal Investigator: Paul Haber, MBBS Less <<
NCT01081795 Migraine Phase 2 Completed - Japan ... More >> Bunkyo, Japan Chitose, Japan Hachioji, Japan Iruma, Japan Isehara, Japan Iwate, Japan Kagoshima, Japan Kamogawa, Japan Kitakyushu, Japan Kobe, Japan Kumamoto, Japan Kyoto, Japan Minato, Japan Morioka, Japan Nagoya, Japan Nishinomiya, Japan Sagamihara, Japan Sapporo, Japan Shimotsuga, Japan Shinjuku-Ku, Japan Shinjuku, Japan Shizuoka, Japan Suginami-Ku, Japan Tokyo, Japan Toyama, Japan Toyonaka, Japan Ube N/A, Japan Ube, Japan Yokohama, Japan Yonago N/A, Japan Less <<
NCT01081795 - Completed - -
NCT00203463 PTSD Phase 4 Completed - United States, Alabama ... More >> Tuscaloosa Research & Education Advancement Corporation Tuscaloosa, Alabama, United States, 35404 Less <<
NCT00572117 Bipolar Disorder|Alcoholism|Al... More >>cohol Dependence Less << PHASE4 COMPLETED 2025-07-14 Stanford/VA Palo Alto Mood Dis... More >>order Research Program, Palo Alto, California, 94304, United States Less <<
NCT00572117 Bipolar Disorder|Alcoholism|Al... More >>cohol Dependence Less << PHASE4 COMPLETED 2025-07-14 Stanford/VA Palo Alto Mood Dis... More >>order Research Program, Palo Alto, California, 94304, United States Less <<
NCT00802412 Nicotine Dependence ... More >> Alcohol Dependence Less << Phase 2 Completed - United States, California ... More >> VA San Diego Healthcare System, San Diego, CA San Diego, California, United States, 92161 Less <<
NCT02201251 Epilepsy Phase 3 Recruiting November 30, 2021 -
NCT00802412 - Completed - -
NCT02239913 Cocaine Use Disorder Phase 1 Recruiting June 2019 United States, Kentucky ... More >> University of Kentucky Medical Center Recruiting Lexington, Kentucky, United States, 40536 Contact: William W Stoops, Ph.D.    859-257-5388    william.stoops@uky.edu    Principal Investigator: Craig R Rush, Ph.D. Less <<
NCT03335163 Migraine|Migraine;Menstrual|Co... More >>ntraception Less << PHASE1 COMPLETED 2021-04-22 University of Colorado Denver,... More >> Aurora, Colorado, 80045, United States Less <<
NCT02273804 Obese Children and Adolescents Phase 3 Completed - France ... More >> Hopital Bicêtre Le Kremlin-Bicêtre, Paris, France, 94275 Less <<
NCT03308669 Healthy Phase 1 Completed - United States, Wisconsin ... More >> Covance Madison CRU Madison, Wisconsin, United States, 53704 Less <<
NCT01229735 Epilepsy Phase 4 Completed - Korea, Republic of ... More >> 14 Busan, Korea, Republic of 21 Busan, Korea, Republic of 8 Busan, Korea, Republic of 9 Busan, Korea, Republic of 12 Daegu, Korea, Republic of 13 Daegu, Korea, Republic of 10 Daejeon, Korea, Republic of 25 Daejeon, Korea, Republic of 15 Gwangju, Korea, Republic of 7 Incheon, Korea, Republic of 11 Kyunggi-Do, Korea, Republic of 19 Kyunggi-do, Korea, Republic of 23 Kyunggi-Do, Korea, Republic of 24 Kyunggi-Do, Korea, Republic of 16 Seoul, Korea, Republic of 17 Seoul, Korea, Republic of 18 Seoul, Korea, Republic of 1 Seoul, Korea, Republic of 2 Seoul, Korea, Republic of 3 Seoul, Korea, Republic of 4 Seoul, Korea, Republic of 5 Seoul, Korea, Republic of 6 Seoul, Korea, Republic of 22 Ulsan, Korea, Republic of Less <<
NCT00206336 - Completed - -
NCT01087736 PTSD Alcohol ... More >>Abuse Alcoholism Less << Phase 4 Completed - United States, California ... More >> San Francisco VA Medical Center San Francisco, California, United States, 94121 Less <<
NCT01087736 - Completed - -
NCT00206336 Tourette Syndrome Phase 3 Completed - -
NCT00626925 Alcohol Drinking Phase 4 Completed - United States, Pennsylvania ... More >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00626925 - Completed - -
NCT02191579 Migraine Disorders Phase 4 Completed - -
NCT00902473 Healthy COMPLETED 2025-10-01 MDS Pharina Services (Clinical... More >> Research Center), Quebec, H4R 2N6, Canada Less <<
NCT01229735 - Completed - -
NCT02191579 - Completed - -
NCT00394095 Bipolar Disorder ... More >> Weight Gain Less << Phase 4 Completed - United States, Ohio ... More >> University of Cincinnati Medical Center Cincinnati, Ohio, United States, 45267-0559 Less <<
NCT01764685 - Terminated(We terminated the s... More >>tudy due to problems recruiting alcoholic subjects with HIV.) Less << - -
NCT01110434 Cannabis Abuse ... More >> Cannabis Dependence Less << Phase 2 Completed - United States, Rhode Island ... More >> Brown University, Center for Alcohol and Addiction Studies Providence, Rhode Island, United States, 02912 Less <<
NCT00901784 Healthy COMPLETED 2025-10-01 MDS Pharina Services (Clinical... More >> Research Center), St. Laurent, Québec, H4R 2N6, Canada Less <<
NCT00300742 Alcohol Dependence|Binge Eatin... More >>g Less << PHASE2 COMPLETED 2025-07-08 UVA CARE, Charlottesville, Vir... More >>ginia, 22911, United States|UVA CARE Richmond, Richmond, Virginia, 23294, United States Less <<
NCT01764685 Heavy Drinking ... More >> HIV Alcohol Dependence Less << Phase 2 Terminated(We terminated the s... More >>tudy due to problems recruiting alcoholic subjects with HIV.) Less << - United States, Pennsylvania ... More >> University of Pennsylvania Treatment Research Center Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT01689649 Epilepsy PHASE4 COMPLETED 2010-01-19 Hanoi, Vietnam|Hochiminh, Viet... More >>nam Less <<
NCT01789047 Idiopathic Parkinson's Disease... More >> Drug Induced Dyskinesia Less << Phase 2 Terminated(Sponsor withdrew su... More >>pport) Less << - United States, Alabama ... More >> University of Alabama Birmingham, Alabama, United States, 35233 United States, Florida University of South Florida Tampa, Florida, United States, 33612 United States, Illinois Rush University Medical Center Chicago, Illinois, United States, 60612 United States, North Carolina Duke University Durham, North Carolina, United States, 27705 United States, Oregon Oregon Health Sciences University Portland, Oregon, United States, 97201 Less <<
NCT00394095 - Completed - -
NCT02113787 Epilepsy Phase 4 Completed - Korea, Republic of ... More >> Seoul National University Hospital Seoul, Korea, Republic of Less <<
NCT03767062 Medication Overuse Headache ... More >> Chronic Migraine, Headache Less << Not Applicable Completed - Turkey ... More >> Mustafa Ceylan Erzurum, Turkey, 25000 Less <<
NCT01689649 Epilepsy PHASE4 COMPLETED 2010-01-19 Hanoi, Vietnam|Hochiminh, Viet... More >>nam Less <<
NCT02639598 Chronic Migraine Phase 4 Completed - -
NCT01859013 - Completed - -
NCT02074904 - Terminated(We terminated the s... More >>tudy to run it as a sub-study of NCT02371889, which is a 13 week, placebo controlled, double-blind, trial of topiramate in heavy drinkers.) Less << - -
NCT00300742 Alcohol Dependence|Binge Eatin... More >>g Less << PHASE2 COMPLETED 2025-07-08 UVA CARE, Charlottesville, Vir... More >>ginia, 22911, United States|UVA CARE Richmond, Richmond, Virginia, 23294, United States Less <<
NCT01765218 Hypoxic Ischemic Encephalopath... More >>y Less << Phase 1 Phase 2 Recruiting May 2020 United States, California ... More >> UC Davis Medical Center Recruiting Sacramento, California, United States, 95822 Contact: Kristin R Hoffman, MD    916-734-3261    krhoffman@ucdavis.edu    Contact: Catherine Rottkamp, MD       carottkamp@ucdavis.edu    Principal Investigator: Kristin R Hoffman, MD          Sub-Investigator: Catherine Rottkamp, MD, PhD          Sub-Investigator: Sameeia Iqbal, MD Less <<
NCT02074904 Alcohol Drinking Phase 2 Terminated(We terminated the s... More >>tudy to run it as a sub-study of NCT02371889, which is a 13 week, placebo controlled, double-blind, trial of topiramate in heavy drinkers.) Less << - United States, Pennsylvania ... More >> University of Pennsylvania Center for Studies of Addiction Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00606411 Sleep-Related Eating Disorder Early Phase 1 Recruiting - United States, Massachusetts ... More >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Less <<
NCT01859013 Obesity, Morbid ... More >> Obesity Weight Loss Less << Phase 2 Completed - United States, Minnesota ... More >> University of Minnesota Minneapolis, Minnesota, United States, 55455 Less <<
NCT01799590 Migraine PHASE2 COMPLETED 2025-11-09 Chitose, Japan|Hachioji, Japan... More >>|Isehara, Japan|Iwate, Japan|Kagoshima, Japan|Kamogawa, Japan|Kitakyushu, Japan|Kobe, Japan|Kumamoto, Japan|Kyoto, Japan|Minato, Japan|Morioka, Japan|Nagoya, Japan|Nishinomiya, Japan|Sagamihara N/A, Japan|Sapporo, Japan|Shinjuku-Ku, Japan|Shizuoka, Japan|Suginami-Ku, Japan|Tokyo, Japan|Toyama, Japan|Toyonaka, Japan|Ube, Japan|Yokohama, Japan|Yonago N/A, Japan Less <<
NCT01145677 Alcohol Dependence PHASE2|PHASE3 COMPLETED 2025-06-11 Chiang Mai Drug Dependence Tre... More >>atment Center, Maerim, Chiang Mai, 50180, Thailand|Maharaj Nakorn Chiang Mai Hospital, Muang, Chiang Mai, 50200, Thailand|Suanprung Psychiatric Hospital, Muang, ChiangMai, 50100, Thailand|Maharaj Nakorn Chiang Mai Hospital, Muang, ChiangMai, 50200, Thailand Less <<
NCT01408641 Alcohol Dependence ... More >> Alcoholism Alcohol Abuse Alcohol Use Disorder PTSD Posttraumatic Stress Disorder Less << Not Applicable Terminated(Principal Investiga... More >>tor was deployed overseas) Less << - United States, Maryland ... More >> Baltimore VA, VA Maryland Health Care System Baltimore, Maryland, United States, 21201 Less <<
NCT01408641 - Terminated(Principal Investiga... More >>tor was deployed overseas) Less << - -
NCT01135602 Alcohol Dependence PHASE4 UNKNOWN 2025-03-12 Maharaj Nakorn Chiang Mai Hosp... More >>ital, Muang, Chiang Mai, 50200, Thailand|Maharaj Nakorn Chiang Mai Hospital, Muang, Chiang Mai, 50200, Thailand Less <<
NCT01799590 Migraine PHASE2 COMPLETED 2025-11-09 Chitose, Japan|Hachioji, Japan... More >>|Isehara, Japan|Iwate, Japan|Kagoshima, Japan|Kamogawa, Japan|Kitakyushu, Japan|Kobe, Japan|Kumamoto, Japan|Kyoto, Japan|Minato, Japan|Morioka, Japan|Nagoya, Japan|Nishinomiya, Japan|Sagamihara N/A, Japan|Sapporo, Japan|Shinjuku-Ku, Japan|Shizuoka, Japan|Suginami-Ku, Japan|Tokyo, Japan|Toyama, Japan|Toyonaka, Japan|Ube, Japan|Yokohama, Japan|Yonago N/A, Japan Less <<
NCT02884050 Alteration of Cognitive Functi... More >>on Less << Phase 1 Completed - -
NCT01641445 Alcohol Drinking Phase 1 Phase 2 Unknown August 2016 United States, Rhode Island ... More >> Brown University, Center for Alcohol and Addiction Studies Recruiting Providence, Rhode Island, United States, 02912 Contact: Robert Jr.    401-863-6658    Robert_Miranda_Jr@Brown.EDU    Contact: Peter Monti    4018636661    Peter_Monti@brown.edu    Sub-Investigator: Peter Monti, Ph.D.          Sub-Investigator: Jennifer Tidey, Ph.D.          Sub-Investigator: Robert Swift, MD, Ph.D.          Sub-Investigator: Damaris Rohsenow, Ph.D.          Sub-Investigator: Chad Gwaltney, Ph.D.          Sub-Investigator: Alicia Justus, Ph.D. Less <<
NCT00846495 - Completed - -
NCT02424318 Migraine Disorders PHASE4 COMPLETED 2025-12-10 -
NCT03018704 Alcohol Use Disorder Phase 4 Recruiting September 29, 2022 United States, Pennsylvania ... More >> Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: David W Oslin, MD    215-823-5870    Dave.Oslin@va.gov    Principal Investigator: David W. Oslin, MD Less <<
NCT02810483 Prader-Willi Syndrome Phase 3 Terminated - France ... More >> Hôpital La Pitié Salpêtrière Paris, France, 75013 Less <<
NCT02808533 Schizophrenia, Schizoaffective... More >> Disorder Less << Not Applicable Recruiting December 2018 Canada, Ontario ... More >> Center for Addiction and Mental Health Recruiting Toronto, Ontario, Canada, M5T 1R8 Contact: Margaret K Hahn, MD    4165358501 ext 34368    margaret.hahn@camh.ca    Contact: Zohra A Ahsan, HBSc    4165358501 ext 34103    zohra.ahsan@camh.ca    Principal Investigator: Margaret K Hahn, MD, PhD Less <<
NCT00846495 Migraine Phase 4 Completed - United States, Florida ... More >> Physician Associates LLC Oviedo, Florida, United States, 32765 United States, Missouri Clinvest Springfield, Missouri, United States, 65807 Less <<
NCT02138058 Compulsive Shopping Phase 2 Completed - Brazil ... More >> Associação Viver Bem São Paulo, SP, Brazil, 05404-010 Less <<
NCT03120468 Alcoholism Early Phase 1 Recruiting April 2018 United States, Virginia ... More >> UVA Center for Leading Edge Addiction Research Recruiting Charlottesville, Virginia, United States, 22903 Contact: Eva Jenkins-Mendoza    434-243-0562    emj9c@virginia.edu    Contact: Tracie Kostelac    (434)243-0563    tlk5d@virginia.edu Less <<
NCT02169830 Migraine Disorders Not Applicable Recruiting December 2020 United States, Missouri ... More >> Saint Louis University Recruiting Saint Louis, Missouri, United States, 63110 Contact: Deniece D Webb, BA    314-268-7407    deniece.webb@health.slu.edu    Contact: Anthony Mikulec, MD    314-577-8884    anthony.mikulec@health.slu.edu    Principal Investigator: Anthony Mikulec, MD Less <<
NCT01682681 Epilepsy COMPLETED 2025-05-09 -
NCT02878798 Cryptogenic Sensory Peripheral... More >> Neuropathy in Metabolic Syndrome Less << Phase 2 Recruiting December 2021 United States, Alabama ... More >> University of Alabama Birmingham Recruiting Birmingham, Alabama, United States, 35233 Contact: Melanie Benge    205-975-0445    melaniebenge@uabmc.edu    Principal Investigator: Eroboghene Ubogu, MD          United States, Colorado University of Colorado Denver Recruiting Aurora, Colorado, United States, 80045 Contact: Brianna Blume    303-724-6386    brianna.blume@ucdenver.edu    Principal Investigator: Dianna Quan, MD          United States, Florida University of Miami Recruiting Miami, Florida, United States, 33136 Contact: Wendy Levy    305-243-6725    wel20@med.miami.edu    Principal Investigator: Mario Saporta, MD, PhD          United States, Illinois Northwestern University Recruiting Chicago, Illinois, United States, 60611 Contact: Tina Ward    312-503-2128    tina.ward@northwestern.edu    Principal Investigator: Daniela Menichella, MD, PhD          United States, Kansas University of Kansas Medical Center Recruiting Kansas City, Kansas, United States, 66160 Contact: Chad Parks    913-945-9938    cparks@kumc.edu    Principal Investigator: Mamatha Pasnoor, MD          United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Peter James    617-643-4218    pfjames@partners.org    Principal Investigator: Reza Seyedsadjadi, MD          United States, Missouri Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 Contact: Mengesha Teshome    314-747-8420    teshomem@wustl.edu    Principal Investigator: Glenn Lopate, MD          United States, New York Columbia University Medical Center Recruiting New York, New York, United States, 10032 Contact: Arruem Kim    212-305-6036    ak3905@cumc.columbia.edu    Principal Investigator: Thomas Brannagan, MD          University of Rochester Medical Center Recruiting Rochester, New York, United States, 14642 Contact: Janet Sowden    585-275-1267    janet_sowden@urmc.rochester.edu    Principal Investigator: David Herrmann, MBBCh, MD          United States, Ohio Ohio State University Recruiting Columbus, Ohio, United States, 43221 Contact: Amy Bartlett    614-366-9050    amy.bartlett@osumc.edu    Principal Investigator: Amro Stino, MD          United States, Tennessee Vanderbilt University Medical Center Recruiting Nashville, Tennessee, United States, 37232 Contact: Kelly Lowen    615-936-0209    kelly.lowen@vumc.org    Principal Investigator: Amanda Peltier, MD          United States, Texas UT Southwestern Medical Center Not yet recruiting Dallas, Texas, United States, 75390 Contact: Mariam Andersen    214-648-6329    mariam.andersen@utsouthwestern.edu    Principal Investigator: Lauren Phillips, MD          United States, Virginia Eastern Virginia Medical Center Recruiting Norfolk, Virginia, United States, 23510 Contact: Carolina Caselllini    757-446-7976    casellcm@evms.edu    Principal Investigator: Aaron Vinik, MD,PhD          Virginia Commonwealth University Not yet recruiting Richmond, Virginia, United States, 23298 Contact: Gordon Smith, MD    804-828-9556    gordon.smith@vcuhealth.org    Contact: Brittney A Holmberg    804-658-6439    brittney.holmberg@vcuhealth.org    Principal Investigator: Gordon Smith, MD Less <<
NCT01682681 Epilepsy COMPLETED 2025-05-09 -
NCT01381523 - Completed - -
NCT01606813 Overweight Ob... More >>ese Less << Not Applicable Completed - United States, Pennsylvania ... More >> Penn State Hershey Medical Center Hershey, Pennsylvania, United States, 17033 Less <<
NCT02727101 Epilepsy Phase 4 Terminated(slow enrollment) - United States, Maryland ... More >> MidAtlantic Epilepsy and Sleep Center Bethesda, Maryland, United States, 20817 Less <<
NCT01713946 Tuberous Sclerosis Complex-ass... More >>ociated Refractory Seizures Less << Phase 3 Completed - -
NCT02205931 Epilepsy Phase 4 Recruiting June 2019 United Kingdom ... More >> Birmingham Children's Hospital Recruiting Birmingham, United Kingdom, B4 6NH Contact: Shakti Agrawal, MBBS    0044 1213338149    shakti.agrawal@bch.nhs.uk    Principal Investigator: Shakti Agrawal, MBBS          Bristol Royal Hospital for Children Recruiting Bristol, United Kingdom, BS2 8AE Contact: Andrew Mallick, FRCPCH          Principal Investigator: Andrew Mallick          Addenbrooke's Hospital Recruiting Cambridge, United Kingdom, CB2 0QQ Contact: Alasdair Parker, MA    0044 1223 245151    alasdair.parker@addenbrookes.nhs.uk    Principal Investigator: Alasdair Parker, MA          Lancashire Teaching Hospitals NHS Foundation Trust Recruiting Lancashire, United Kingdom Contact: Helen Basu       Helen.Basu@lthtr.nhs.uk    Principal Investigator: Helen Basu          Leeds Teaching Hospital Recruiting Leeds, United Kingdom, LS1 3EX Contact: Helen McCullagh, RCPCH    0044 113 243 2799    h.mccullagh@nhs.net    Principal Investigator: Helen McCullagh, RCPCH          Alder Hey Children's Hospital Recruiting Liverpool, United Kingdom, L12 2AP Contact: Rachel Kneen, BMBS    0044 151 2525163    rachel.kneen@liverpool.ac.uk    Principal Investigator: Rachel Kneen, BMBS          Great Ormond Street Hospital Recruiting London, United Kingdom, WC1N 3JH Contact: Christin Eltze, MD Res    0044 207 405 9200 ext 5438    christin.eltze@gosh.nhs.uk    Principal Investigator: Christin Eltze, MD Res          St George's University Hospitals NHS Foundation Trust Recruiting London, United Kingdom Contact: Penny Fallon       Penny.Fallon@stgeorges.nhs.uk    Principal Investigator: Penny Fallon          Royal Manchester Children's Hospital Recruiting Manchester, United Kingdom, M13 0JE Contact: Tim Martland, RCPCH    0044 161 276 1234    timothy.martland@cmft.nhs.uk    Principal Investigator: Tim Martland, RCPCH          The Newcastle Upon Tyne Hospitals NHS Foundation Trust Recruiting Newcastle upon Tyne, United Kingdom Contact: Anita Devlin       Anita.Devlin@nuth.nhs.uk    Principal Investigator: Anita Devlin          Sheffield Children's NHS Foundation Trust Recruiting Sheffield, United Kingdom Contact: Archana Desurkar       Archana.Desurkar@sch.nhs.uk    Principal Investigator: Archana Desurkar Less <<
NCT02707965 Epilepsy Phase 4 Completed - United States, Maryland ... More >> University of Maryland, Baltimore Baltimore, Maryland, United States, 21201 Less <<
NCT02607891 Epilepsy Phase 2 Recruiting August 2018 France ... More >> Not yet recruiting Elancourt, France Not yet recruiting Paris, France Not yet recruiting Rennes, France Netherlands Not yet recruiting Zwolle, Netherlands Poland Not yet recruiting Kraków, Poland Romania Not yet recruiting Bucuresti, Romania Spain Recruiting Barcelona, Spain Recruiting Madrid, Spain Recruiting Sevilla, Spain Sweden Recruiting Goteborg, Sweden Less <<
NCT01713946 - Completed - -
NCT02374567 Dementia Depr... More >>ession Schizophrenia Psychosomatic Disorders Anxiety Disorders Less << Phase 3 Terminated - Germany ... More >> Bezirkskrankenhaus Augsburg Augsburg, Germany Krankenhaus Hedwigshöhe Berlin, Germany Hannover Medical School Hannover, Germany, 30625 Asklepios Fachklinikum Lübben Lübben, Germany Asklepios Fachklinikum Teupitz Teupitz, Germany Less <<
NCT00806260 Overweight Ob... More >>esity Less << Phase 2 Completed - United States, Nebraska ... More >> Research Site Lincoln, Nebraska, United States, 68502 Less <<
NCT00659035 - Active, not recruiting July 2020 United States, Illinois ... More >> Rush University Medical Center Chicago, Illinois, United States, 60612 Less <<
NCT00404248 Brain and Central Nervous Syst... More >>em Tumors Less << Phase 1 Phase 2 Completed - United States, Alabama ... More >> UAB Comprehensive Cancer Center Birmingham, Alabama, United States, 35294-3410 United States, Florida H. Lee Moffitt Cancer Center and Research Institute at University of South Florida Tampa, Florida, United States, 33612-9497 United States, Georgia Winship Cancer Institute of Emory University Atlanta, Georgia, United States, 30322 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Michigan Josephine Ford Cancer Center at Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, North Carolina Wake Forest University Comprehensive Cancer Center Winston-Salem, North Carolina, United States, 27157-1096 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 United States, Pennsylvania Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 Less <<
NCT00552526 Epilepsy Ment... More >>al Retardation Less << Phase 4 Unknown December 2013 Norway ... More >> SSE, Nevrological dep. , Rikshospitalet University hospital Oslo, Norway Less <<
NCT00806260 - Completed - -
NCT00404248 - Completed - -
NCT03636958 Refractory Epilepsy Not Applicable Not yet recruiting December 2022 France ... More >> Assistance Publique Des Hopitaux de Marseille Not yet recruiting Marseille, Paca, France, 13354 Contact: STANISLAS LAGARDE, MD    +33 491385554    Stanislas.LAGARDE@ap-hm.fr Less <<
NCT00068770 Brain and Central Nervous Syst... More >>em Tumors Less << Phase 2 Terminated(EORTC trail showed ... More >>TMZ & RT conferred significant survivial in this population) Less << - United States, Florida ... More >> H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612-9497 United States, Georgia Winship Cancer Institute of Emory University Atlanta, Georgia, United States, 30322 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231-2410 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114-2617 United States, North Carolina Comprehensive Cancer Center at Wake Forest University Winston-Salem, North Carolina, United States, 27157-1030 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 United States, Pennsylvania Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 Less <<
NCT00553787 Obesity Type ... More >>2 Diabetes Less << Phase 3 Completed - United States, Alabama ... More >> Research Site Birmingham, Alabama, United States, 35294 United States, Connecticut Research Site Ridgefield, Connecticut, United States, 06877 United States, New York Research Site New York, New York, United States, 10025 United States, North Carolina Research Site Durham, North Carolina, United States, 27710 United States, Ohio Research Site Toledo, Ohio, United States, 43623 United States, Texas Research Site Austin, Texas, United States, 78731 Less <<
NCT00553787 - Completed - -
NCT00704860 Major Depression Phase 4 Completed - Canada, Ontario ... More >> University of Ottawa Institute of Mental Health Research Ottawa, Ontario, Canada, K1Z 7K4 Less <<
NCT02300051 Compulsive Sexual Behavior Not Applicable Completed - Brazil ... More >> Instituto de Psiquiatria do Hospital das Clínicas da Universidade de São Paulo[University of Sao Paulo General Hospital] São Paulo, Brazil, 05403010 Less <<
NCT02403687 - Completed - -
NCT00068770 - Terminated(EORTC trail showed ... More >>TMZ & RT conferred significant survivial in this population) Less << - -
NCT02670161 Brain Tumors ... More >>Epilepsy Migraine Mild Cognitive Impairment Concussion Multiple Sclerosis Neuropathy Parkinson's Restless Legs Syndrome Stroke Less << Phase 4 Enrolling by invitation April 2020 -
NCT00759993 Weight Gain O... More >>besity Less << Phase 2 Terminated(inability to recrui... More >>t and retain) Less << March 2013 -
NCT03671681 Chronic Migraine ... More >> Medication Overuse Headache Less << Not Applicable Not yet recruiting November 2021 Italy ... More >> Fondazione IRCCS Istituto Neurologico C. Besta, Neuroalgology Unit Not yet recruiting Milano, Italy, 20133 Contact: Domenico D'Amico, MD       domenico.damico@istituto-besta.it    Principal Investigator: Domenico D'Amico, MD Less <<
NCT00539188 Borderline Personality Disorde... More >>r Self-Injurious Behavior Less << Phase 2 Terminated(Study terminated du... More >>e to poor subject compliance.) Less << - United States, Connecticut ... More >> Yale OCD Research Clinic New Haven, Connecticut, United States, 06519 Less <<
NCT00539188 - Terminated(Study terminated du... More >>e to poor subject compliance.) Less << - -
NCT02499393 Perinatal Anoxic-ischemic Brai... More >>n Injury Less << Phase 2 Phase 3 Completed - Poland ... More >> Polish Mother Memorial Hospital - Research Instutiute Lodz, Poland, 93-338 Less <<
NCT03107507 Neonatal Seizures Phase 4 Recruiting December 30, 2017 Egypt ... More >> Cairo University Children's Hospital (Abulreesh) Recruiting Cairo Governorate, Egypt Contact: Yara Shaheen Less <<
NCT03050827 Diabetic; Neuropathic, Polyneu... More >>ropathy (Manifestation) Less << Phase 3 Completed - United States, Virginia ... More >> Eastern Virgnia Medical School, Strelitz Diabetes Center Norfolk, Virginia, United States, 23510f Less <<
NCT01549288 Infantile Spasms Phase 2 Phase 3 Withdrawn December 2013 India ... More >> Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital New Delhi, Delhi, India, 110001 Less <<
NCT01390909 - Completed - -
NCT00635960 Amyotrophic Lateral Sclerosis Phase 2 Completed - Italy ... More >> Diparimento di Scienze Neurologiche Naples, Italy, 80131 Istituto Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche Naples, Italy, 80131 Less <<
NCT01390909 - Completed - -
NCT03196466 - Recruiting June 2019 France ... More >> AP-HP Cochin Recruiting Paris, France, 75014 Contact: Jean-Marc Treluyer, M.D., PhD    + 00 1 58 41 28 85    jean-marc.treluyer@parisdescartes.fr Less <<
NCT00486291 Type 2 Diabetes Mellitus Phase 2 Completed - United States, Alabama ... More >> Research Site Birmingham, Alabama, United States United States, California Research Site Los Angeles, California, United States Research Site San Francisco, California, United States Research Site Spring Valley, California, United States Research Site Walnut Creek, California, United States United States, Maryland Research Site Bethesda, Maryland, United States United States, Texas Research Site Austin, Texas, United States Research Site San Antonio, Texas, United States United States, Virginia Research Site Richmond, Virginia, United States Less <<
NCT02429596 Epilepsy Phase 4 Unknown May 2015 Italy ... More >> Clinica Neurologica, Ospedali Riuniti Not yet recruiting Ancona, Italy Contact: Leandro Provinciali, MD       leandroprovinciali@gmail.com    Clinica Neurologica Amaducci, Policlinico di Bari Not yet recruiting Bari, Italy Contact: Angela La Neve, MD       centroepilessia@neurol.uniba.it    Principal Investigator: Angela La Neve, MD          U.S.C. Neurologia, Ospedali Riuniti Active, not recruiting Bergamo, Italy Dipartimento di Scienze Neurologiche, Università degli Studi di Bologna Recruiting Bologna, Italy Contact: Agostino Baruzzi, MD       agostino.baruzzi@unibo.it    Contact: Barbara Mostacci, MD       barbara.mostacci@unibo.it    Principal Investigator: Agostino Baruzzi, MD          Unità Operativa Complessa di Neurologia, Ospedale di Bellaria Recruiting Bologna, Italy Contact: Roberto Michelucci, MD       roberto.michelucci@ausl.bologna.it    Contact: Lilia Volpi, MD       lilia.volpi@ausl.bologna.it    Centro Regionale dell'Epilessia, Azienda Ospedaliera Spedali Civili Not yet recruiting Brescia, Italy Contact: Luisa Antonini, MD       luisa.antonini@spedalicivili.brescia.it    Azienda Ospedaliera, Policlinico Universitario Mater Domini Completed Catanzaro, Italy, 88100 Azienda Ospedaliera ospedali Riuniti Active, not recruiting Foggia, Italy Azienda Ospedaliera Universitaria Policlinico Gaetano Martino Not yet recruiting Messina, Italy Contact: Edoardo Spina, MD       espina@unime.it    Principal Investigator: Edoardo Spina, MD          Clinica Neurologica, Ospedale San Gerardo Not yet recruiting Monza, Italy Contact: Carlo Ferrarese, MD       carlo.ferrarese@unimib.it    Contact: Simone Beretta, MD       simone.beretta@unimib.it    Clinica Neurologica, Azienda Ospedaliero-Universitaria Maggiore della Carità Recruiting Novara, Italy Contact: Roberto Cantello, MD          Contact: Claudia Varrasi, MD       claudia.varrasi@libero.it    S.C. di Neurofisiopatologia, Centro di Riferimento Regionale Umbro per l'Epilessia Not yet recruiting Perugia, Italy Contact: Teresa Anna Cantisani, MD       cantisani@yahoo.com    UO di Neurologia, Azienda Ospedaliero Universitaria Pisana Active, not recruiting Pisa, Italy Centro Regionale Epilessie, Reggio Calabria e Università della Magna Graecia Recruiting Reggio Calabria, Italy Contact: Umberto Aguglia, MD       u.aguglia@tin.it    Contact: Sara Gasparini, MD          Dipartimento di Scienze Neurologiche, III Clinica Neurologica, Università "La Sapienza" Not yet recruiting Roma, Italy Contact: Anna Teresa Giallonardo, MD       annateresa.giallonardo@uniroma1.it    Unità Complessa di Neurologia, Ospedale SS. Giovanni e Paolo Not yet recruiting Venezia, Italy Contact: Francesco Paladin, MD Less <<
NCT00004807 Rett Syndrome Not Applicable Completed - -
NCT00745251 Sleep Apnea Phase 1 Phase 2 Completed - United States, Kentucky ... More >> Kentucky Research Group Louisville, Kentucky, United States, 40217 Less <<
NCT01000402 Bipolar Disorder ... More >> Attention Deficit Disorder With Hyperactivity Less << Phase 4 Unknown November 2014 Brazil ... More >> Hospital de Clinicas de Porto Alegre Recruiting Porto Alegre, RS, Brazil, 90350-903 Contact: Clarissa F Paim    +55 51 21018094    cfpaim@hcpa.ufrgs.br    Contact: Silza Tramontina, D.Sc.    +55 51 21018094    silza.tramontina@terra.com.br    Principal Investigator: Luis A Rohde, D.Sc.          Sub-Investigator: Silza Tramontina, D.Sc.          Sub-Investigator: Cristian P Zeni, M.Sc.          Sub-Investigator: Carla R Ketzer, M.Sc.          Sub-Investigator: Gabriel F Pheula, MD          Sub-Investigator: Fernanda V Krieger, MD          Sub-Investigator: Sandra Petresco, M.Sc.          Sub-Investigator: Roberta S Coelho, B.Sc.          Sub-Investigator: Adriana F Perez, M.Sc.          Sub-Investigator: Lanuzia Brum, BA          Sub-Investigator: Ana P Guimaraes, M.Sc.          Sub-Investigator: Henrique T Ludwig Less <<
NCT00241995 Topiramate La... More >>motrigine Memnatine Diazepam Placebo Less << Not Applicable Completed - -
NCT02993861 - Recruiting September 2018 United States, Colorado ... More >> The Children's Hospital Colorado Not yet recruiting Aurora, Colorado, United States, 80045 Contact: Austin Drake    720-777-4719    austin.drake@childrenscolorado.org    Contact: Charuta Joshi, MD    1-720-777-6895    charuta.joshi@childrenscolorado.org    United States, Delaware Nemours Alfred I. DuPont Hospital for Children Recruiting Wilmington, Delaware, United States, 19803 Contact: Ramany John    302-298-7521    ramany.john@nemours.org    Contact: Marisa Meyer, MD    1-302-651-4021    marisa.meyer@nemours.org    United States, Georgia Childrens Healthcare of Atlanta Recruiting Atlanta, Georgia, United States, 30324 Contact: Sims Christopher    404-785-8798    christopher.sims@choa.org    Contact: Ton DeGrauw, MD    1-404-785-4446    ton.degrauw@choa.org    United States, Illinois Ann and Robert H. Lurie Children's Hospital of Chicago Recruiting Chicago, Illinois, United States, 60611 Contact: Laura Fearn    312-227-6280    lfearn@luriechildrens.org    Contact: William Muller, MD    312-503-3218    wjmuller@northwestern.edu    United States, Kentucky University of Louisville Norton Childrens Hospital Recruiting Louisville, Kentucky, United States, 40202 Contact: Terri Simeon    502-629-5820    theresa.simeon@louisville.edu    Contact: Arpita Lakhotia, MD    1-502-629-5820    arpita.lakhotia@louisville.edu    United States, North Carolina University of North Carolina at Chapel Hill Recruiting Chapel Hill, North Carolina, United States, 27514 Contact: Shradhdha Joshi    919-966-9051    snjoshi@neurology.unc.edu    Contact: Yael Shiloh-Malawsky, MD    919-966-2922    yaelm@neurology.unc.edu    Duke University Health System Recruiting Durham, North Carolina, United States, 27705 Contact: Kanecia Zimmerman, MD    919-668-8651    kanecia.obie@dm.duke.edu    Contact: Harward Melissa    919-668-3910    melissa.harward@dm.duke.edu    Coastal Children's Services Not yet recruiting Wilmington, North Carolina, United States, 28401 Contact: Arielle Lapid    910-667-5483    arielle.lapid@ccneo.net    Contact: Sasidharan Taravath, MD    1-910-667-5165    sasi.taravath@coastalchildrensservices.net    United States, Oregon Oregon Health and Science University Recruiting Portland, Oregon, United States Contact: Kira Clark    503-418-8112    clarki@ohsu.edu    Contact: Amira Al-Uzri    1-503-494-6956    aluzria@ohsu.edu    United States, Texas University of Texas Southwestern Medical Center Dallas Recruiting Dallas, Texas, United States, 75390-8589 Contact: Susan Arnold, MD    214-456-8242    susan.arnold@utsouthwestern.edu    United States, Washington Seattle Children's Hospital Not yet recruiting Seattle, Washington, United States, 98105 Contact: Megan Kelton    206-987-5539    megan.kelton@seattlechildrens.org    Contact: Joseph Flynn, MD    1-206-987-2524    joseph.flynn@seattlechildrens.org Less <<
NCT00745251 - Completed - -
NCT03374956 Obesity Phase 3 Recruiting December 1, 2020 United States, Minnesota ... More >> Mayo Clinic in Rochester Recruiting Rochester, Minnesota, United States, 55905 Contact: Judith Davis    507-266-9447    RSTINDIVOBESITY@mayo.edu    Principal Investigator: Andres J Acosta Less <<
NCT00796367 Obesity Phase 3 Completed - -
NCT00796367 - Completed - -
NCT03689114 Epilepsies, Partial Phase 4 Not yet recruiting December 2021 -
NCT00737633 - Terminated(Limited regulatory ... More >>value to uncontrolled trials. No safety/efficacy concerns.) Less << - -
NCT02229214 Obesity Phase 4 Completed - United States, Colorado ... More >> Research Center Lakewood, Colorado, United States, 80228 Less <<
NCT00486291 - Completed - -
NCT02229214 - Completed - -
NCT00777218 Migraine Not Applicable Unknown July 2011 United States, Alabama ... More >> University of South Alabama Department of Neurology Recruiting Mobile, Alabama, United States, 36693 Sub-Investigator: Maher Loutfi, MD Less <<
NCT00768209 Hepatic Impairment Phase 1 Completed - United States, Florida ... More >> Clinical Pharmacology of Miami Miami, Florida, United States, 33014-3616 Orlando Clinical Research Center Orlando, Florida, United States, 32809-3017 Less <<
NCT01351753 Obesity Metab... More >>olic Syndrome X Less << Phase 2 Suspended(Change of staff) October 2019 United States, Iowa ... More >> University of Iowa Hospitals and Clinics Iowa City, Iowa, United States, 52241 Less <<
NCT02497443 Epilepsy Phase 1 Phase 2 Active, not recruiting December 2019 -
NCT03461874 Migraine Without Aura Not Applicable Recruiting July 15, 2021 Italy ... More >> Fondazione IRCCS Istituto Neurologico C. Besta, Neuroalgology Unit Recruiting Milano, Italy, 20133 Contact: Licia Grazzi, MD       licia.grazzi@istituto-besta.it    Principal Investigator: Licia Grazzi, MD Less <<
NCT00554216 Obesity Phase 3 Completed - United States, California ... More >> Research Site San Diego, California, United States, 92130 United States, Connecticut Research Ridgefield, Connecticut, United States, 06877 United States, North Carolina Research Site Durham, North Carolina, United States, 27710 United States, Ohio Research Site Toledo, Ohio, United States, 43623 United States, Texas Research Site Austin, Texas, United States, 78731 Less <<
NCT01922934 - Completed - -
NCT03125525 - Completed - -
NCT00554216 - Completed - -
NCT00563368 Obesity Phase 3 Completed - United States, North Carolina ... More >> Research Site Durham, North Carolina, United States United States, Pennsylvania Research Site Philadelphia, Pennsylvania, United States Less <<
NCT01922934 Obesity Phase 4 Completed - United States, Colorado ... More >> Denver Health and Hospital Authority Denver, Colorado, United States, 80204 Less <<
NCT00731900 - Unknown December 2009 Taiwan ... More >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Horng-Huei Liou, MD;PhD    886-2-23123456 ext 8325    hhl@ntu.edu.tw Less <<
NCT00563368 - Completed - -
NCT02645370 Migraine Phase 1 Unknown - China, Shanxi ... More >> Xijing Hospital Not yet recruiting Xi'an, Shanxi, China, 710032 Less <<
NCT00737633 Diabetes Phase 2 Terminated(Limited regulatory ... More >>value to uncontrolled trials. No safety/efficacy concerns.) Less << - United States, Alabama ... More >> Research Site Birmingham, Alabama, United States United States, California Research Site Los Angeles, California, United States Research Site San Francisco, California, United States Research Site Spring Valley, California, United States Research Site Walnut Creek, California, United States United States, Maryland Research Site Bethesda, Maryland, United States United States, Texas Research Site Austin, Texas, United States Research Site San Antonio, Texas, United States United States, Virginia Research Site Richmond, Virginia, United States Less <<
NCT02714062 - Completed - -
NCT01161017 Migraine Not Applicable Completed - Israel ... More >> Rambam Medical Center Haifa, Israel Less <<
NCT00600067 Diabetes Phase 2 Completed - United States, Alabama ... More >> Research Site Birmingham, Alabama, United States United States, California Research Site Los Angeles, California, United States Research Site San Francisco, California, United States Research Site Spring Valley, California, United States Research Site Walnut Creek, California, United States United States, Maryland Research Site Bethesda, Maryland, United States United States, Texas Research Site Austin, Texas, United States Research Site San Antonio, Texas, United States United States, Virginia Research Site Richmond, Virginia, United States Less <<
NCT00600067 - Completed - -
NCT00001725 Facial Neuralgia ... More >> Pain Trigeminal Neuralgia Less << Phase 2 Completed - United States, Maryland ... More >> National Institute of Dental And Craniofacial Research (NIDCR) Bethesda, Maryland, United States, 20892 Less <<
NCT00862095 Headache Phase 4 Terminated(inadequate enrollme... More >>nt, insufficient funds to continue enrollment) Less << - United States, Washington ... More >> Madigan Army Medical Center Tacoma, Washington, United States, 98431 Less <<
NCT02714062 Pediatric Obesity ... More >> Childhood Obesity Less << Phase 4 Completed - United States, Louisiana ... More >> Research Facility Baton Rouge, Louisiana, United States, 70808 Research Facility Marrero, Louisiana, United States, 70072 United States, Ohio Research Facility Cincinnati, Ohio, United States, 45229 United States, South Carolina Research Facility Charleston, South Carolina, United States, 29403 Less <<
NCT02635386 Polycystic Ovary Syndrome ... More >> Obesity Less << Phase 3 Recruiting August 2019 United States, Louisiana ... More >> Woman's Hospital Recruiting Baton Rouge, Louisiana, United States, 70815 Contact: Karen Elkind-Hirsch, PhD.    225-231-5278       Contact: Ericka Seidemann, MS    225-231-5275    ericka.seidemann@womans.org    Principal Investigator: Karen Elkind-Hirsch, Ph.D.          Sub-Investigator: Renee Harris, M.D. Less <<
NCT02945839 Migraine Phase 4 Not yet recruiting December 2018 United States, New York ... More >> New York University School of Medicine Not yet recruiting New York, New York, United States, 10016 Contact: Liliana Serrano       Liliana.Serrano2@nyumc.org    Principal Investigator: mia Minen, MD Less <<
NCT00563459 Epilepsy Seiz... More >>ures Less << Phase 3 Terminated(Carisbamate partial... More >> onset seizures studies lacked consistent efficacy data so trials in this indication were terminated.) Less << - -
NCT03307863 Contraception ... More >> Drug Interactions Less << Phase 4 Recruiting July 2019 Brazil ... More >> Hospital das Clínicas de Ribeirão Preto da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo Recruiting Ribeirão Preto, Sao Paulo, Brazil, 14049-900 Contact: Carolina S Vieira, MD    +551636022818    carol.sales@usp.br    Contact: Leticia S Ferreira, MD    +553491924258    lelezinhasanchez1@yahoo.com.br    Principal Investigator: Carolina S Vieira, MD Less <<
NCT00772031 - Completed - -
NCT00208858 Tobacco Use Disorder PHASE2 COMPLETED 2025-12-06 Atlanta VA Medical Center, Dec... More >>atur, Georgia, 30033, United States Less <<
NCT02643719 Migraine Not Applicable Withdrawn(Study team missed co... More >>ntinuing review and study lapsed with out recruiting any subjects.) Less << - -
NCT00768404 Renal Impairment Phase 1 Completed - United States, California ... More >> Advanced Clinical Research Institute Anaheim, California, United States, 92801 United States, Florida Clinical Pharmacology of Miami Miami, Florida, United States, 33014-3616 Orlando Clinical Research Center Orlando, Florida, United States, 32809-3017 United States, Minnesota DaVita Clinical Research Minneapolis, Minnesota, United States, 55404 Less <<
NCT01096420 Patients With Chronic Migraine Not Applicable Completed - Taiwan ... More >> Kuang Tien General Hospital Taichung, Taiwan, 433 Less <<
NCT00772031 Chronic Migraine Phase 3 Completed - -
NCT02659475 Binge Eating Disorder Phase 2 Completed - United States, Ohio ... More >> Lindner Center of HOPE Mason, Ohio, United States, 45040 Less <<
NCT00006205 Alcoholism Phase 2 Unknown December 2013 United States, Virginia ... More >> University of Virginia Center for Addiction Research and Education Recruiting Charlottesville, Virginia, United States, 22911 Contact: Mindy Borszich    888-882-2345    mcb3x@virginia.edu    Contact: Eva Jenkins-Mendoza    (434)243-0562    emj9c@virginia.edu    Principal Investigator: Bankole Johnson, DSc, MD, PhD          Sub-Investigator: Nassima Ait-Daoud Tiouririne, MD          University of Virginia Center for Addiction Research and Education Recruiting Richmond, Virginia, United States, 23294 Contact: Mindy Borszich    888-882-2345    mcb3x@virginia.edu    Contact: Eva Jenkins-Mendoza    (434)243-0562    emj9c@virginia.edu    Principal Investigator: Bankole Johnson, DSc, MD, PhD          Sub-Investigator: Nassima Ait-Daoud Tiouririne, MD Less <<
NCT03603080 Obesity Phase 4 Not yet recruiting November 1, 2019 United States, Connecticut ... More >> Hartford Hospital Not yet recruiting Hartford, Connecticut, United States, 06102 Contact: Pavlos K Papasavas, MD    860-246-2071    pavlos.papasavas@hhchealth.org    Contact: Darren Tishler, MD    8605244566    darren.tishler@hhchealth.org    Sub-Investigator: Pavlos K Papasavas, MD          Sub-Investigator: Darren Tishler, MD          Principal Investigator: Devika Umashanker, MD Less <<
NCT00571246 Alcohol Dependence ... More >> Post Traumatic Stress Disorder Less << Phase 3 Withdrawn June 2016 United States, Connecticut ... More >> VA Connecticut Healthcare System West Haven, Connecticut, United States, 06516 Less <<
NCT02301416 Obesity Metab... More >>olic Surgery Weight Loss Bariatric Surgery Procedures Less << Phase 2 Completed - United States, North Carolina ... More >> Wake Forest Baptist Health Winston-Salem, North Carolina, United States, 27157 Less <<
NCT02553824 Binge Eating Disorder ... More >> Bulimia Nervosa Less << Phase 1 Completed - United States, California ... More >> Stanford School of Medicine, Psychiatry and Behavioral Sciences Stanford, California, United States, 94305 Less <<
NCT00855738 Focal Epilepsy Phase 4 Completed - -
NCT00217295 Multiple Sclerosis Phase 2 Unknown - United States, Pennsylvania ... More >> Multiple Sclerosis Institute Recruiting Philadelphia, Pennsylvania, United States, 19146 Contact: Jeffrey I Greenstein, MD    215-985-2245       Contact: Iris J Gold, MBA    215-985-2245       Principal Investigator: Jeffrey I Greenstein, MD Less <<
NCT00855738 - Completed - -
NCT00154076 Epilepsy Phase 4 Completed - Korea, Republic of ... More >> Daegu Catholic University Medical Center Daegu, Korea, Republic of Less <<
NCT00396734 Opioid-Related Disorders ... More >> Cocaine-Related Disorders Less << Not Applicable Suspended(Grant was not renewe... More >>d) Less << April 2011 Israel ... More >> Hadassah Medical Organization Jerusalem, Israel, 91120 Less <<
NCT00432549 Analgesic Rebound Headache Phase 4 Unknown - United States, Connecticut ... More >> The New England Center for Headache, P.C. Recruiting Stamford, Connecticut, United States, 06902 Principal Investigator: Fred D Sheftell, M.D. Less <<
NCT00208130 Post-Traumatic Stress Disorder PHASE4 COMPLETED 2025-03-04 Creighton University Psychiatr... More >>y and Research Center, Omaha, Nebraska, 68131, United States Less <<
NCT04401137 Migraine PHASE1 COMPLETED 2020-10-06 Seoul National University Hosp... More >>ital, Dept. of Clinical Pharmacology, Seoul, Korea, Republic of Less <<
NCT00131443 Basilar Migraine PHASE2|PHASE3 COMPLETED 2025-08-06 Monarch Medical Research - Chi... More >>ld and Adolescent Neurology, Norfolk, Virginia, 23510, United States Less <<
NCT00065923 Prader-Willi Syndrome|Self-Inj... More >>urious Behavior Less << COMPLETED - University of Florida-Brain In... More >>stitute, Gainesville, Florida, 32609, United States Less <<
NCT00297323 Seizures, Epileptic COMPLETED 2025-02-07 -
NCT00035230 Bipolar Disorder PHASE3 COMPLETED 2025-11-02 -
NCT06282783 HIV-1-infection|Hiv|HIV Infect... More >>ions|HIV I Infection Less << PHASE1|PHASE2 NOT_YET_RECRUITING 2025-08-25 Erasmus Medical Centre, Rotter... More >>dam, Netherlands Less <<
NCT00223639 Alcoholism PHASE2 COMPLETED 2025-07-08 UVA CARE, Charlottesville, Vir... More >>ginia, 22911, United States|UVA CARE Richmond, Richmond, Virginia, 23294, United States Less <<
NCT00212810 Migraine|Headache|Classic Migr... More >>aine|Common Migraine Less << PHASE4 COMPLETED 2025-08-07 -
NCT00203190 Cluster Headache PHASE4 TERMINATED 2025-06-06 Jefferson Headache Center, Phi... More >>ladelphia, Pennsylvania, 19107, United States Less <<
NCT00200941 Restless Legs Syndrome PHASE4 COMPLETED 2025-04-05 Neurocare, Newton, Massachuset... More >>ts, 02459, United States Less <<
NCT00286923 Migraine|Chronic Headache UNKNOWN 2025-08-06 Swedish Headache Clinic, Seatt... More >>le, Washington, 98104, United States Less <<
NCT00187928 Obsessive-Compulsive Disorder PHASE3 COMPLETED 2025-03-06 UF Health Science Center, Gain... More >>esville, Florida, 32608, United States Less <<
NCT00011804 Sciatica PHASE2 COMPLETED 2025-02-05 National Institute of Dental A... More >>nd Craniofacial Research (NIDCR), Bethesda, Maryland, 20892, United States Less <<
NCT00037674 Bipolar Disorder PHASE3 COMPLETED 2025-05-03 -
NCT00158002 Basilar Migraine PHASE2 COMPLETED 2025-08-06 Monarch Medical Research - Chi... More >>ld and Adolescent Neurology, Norfolk, Virginia, 23510, United States Less <<
NCT00286988 Vomiting PHASE4 TERMINATED 2025-06-07 Monarch Medical Research - Chi... More >>ld and Adolescent Neurology, Norfolk, Virginia, 23510, United States Less <<
NCT00204386 Posttraumatic Stress Disorder PHASE2|PHASE3 COMPLETED 2025-05-07 The University of Oklahoma Hea... More >>lth Sciences Center, Oklahoma City, Oklahoma, 73104, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.29mL

14.73mL

2.95mL

1.47mL

29.47mL

5.89mL

2.95mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

Historical Records

Categories