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Chemical Structure| 2133499-85-9 Chemical Structure| 2133499-85-9

Structure of HSP27 inhibitor J2
CAS No.: 2133499-85-9

Chemical Structure| 2133499-85-9

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HSP27 inhibitor J2 specifically inhibits HSP27 function by inducing the formation of aberrant HSP27 dimers, thereby inhibiting its chaperone function. This inhibitor enhances the anticancer effects when combined with cisplatin and is suitable for cancer treatment research.

Synonyms: J2

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Product Details of HSP27 inhibitor J2

CAS No. :2133499-85-9
Formula : C13H12O4S
M.W : 264.30
SMILES Code : O=C1C=C(C)OC2=C1C(O)=CC(OCC3SC3)=C2
Synonyms :
J2
MDL No. :MFCD32201069
InChI Key :VDCWAGBPDCXRDU-UHFFFAOYSA-N
Pubchem ID :135384973

Safety of HSP27 inhibitor J2

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of HSP27 inhibitor J2

DNA

Isoform Comparison

Biological Activity

Description
The HSP27 inhibitor J2 disrupts normal HSP27 dimer formation and prevents the formation of large HSP27 polymers, reducing its chaperone function and cellular protection. J2 significantly boosts the antiproliferative effects of 17-AAG and increases sensitivity to cisplatin-induced inhibition of lung cancer cell growth[1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.78mL

0.76mL

0.38mL

18.92mL

3.78mL

1.89mL

37.84mL

7.57mL

3.78mL

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