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Chemical Structure| 848249-35-4 Chemical Structure| 848249-35-4

Structure of JAMM protein inhibitor 2
CAS No.: 848249-35-4

Chemical Structure| 848249-35-4

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JAMM protein inhibitor 2 is an effective JAMM protease inhibitor with IC50 values of 10 μM for thrombin, 46 μM for Rpn11, and 89 μM for MMP2. It possesses potential anticancer activity by interfering with the cellular proteasome pathway, commonly used in cancer treatment research.

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Product Details of JAMM protein inhibitor 2

CAS No. :848249-35-4
Formula : C21H26N2O2
M.W : 338.44
SMILES Code : CCC1=C(C=CC=C1)OCC(NC2=C(C=C(N3CCCC3)C=C2)C)=O
MDL No. :MFCD07316369
InChI Key :BWVQJXWDZCDJJJ-UHFFFAOYSA-N
Pubchem ID :4853066

Safety of JAMM protein inhibitor 2

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Isoform Comparison

Biological Activity

Description
JAMM Protein Inhibitor 2, a powerful inhibitor of JAMM proteases, shows IC50 values of 10 μM for thrombin, 46 μM for Rpn11, and 89 μM for MMP2, and is suitable for anticancer research[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.30mL

14.77mL

2.95mL

1.48mL

29.55mL

5.91mL

2.95mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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