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Chemical Structure| 173334-58-2 Chemical Structure| 173334-58-2

Structure of Aliskiren hemifumarate
CAS No.: 173334-58-2

Chemical Structure| 173334-58-2

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Aliskiren hemifumarate is an inhibitor of renin with IC50 value of 1.5 nM.

Synonyms: SPP 100 hemifumarate; CGP60536B hemifumarate; SPP 100

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Product Details of Aliskiren hemifumarate

CAS No. :173334-58-2
Formula : C64H110N6O16
M.W : 1219.59
SMILES Code : CC(C)[C@@H](CC1=CC=C(OC)C(OCCCOC)=C1)C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(NCC(C)(C)C(N)=O)=O.CC(C)[C@@H](CC2=CC=C(OC)C(OCCCOC)=C2)C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(NCC(C)(C)C(N)=O)=O.O=C(O)/C=C/C(O)=O
Synonyms :
SPP 100 hemifumarate; CGP60536B hemifumarate; SPP 100
MDL No. :MFCD10566724
InChI Key :KLRSDBSKUSSCGU-KRQUFFFQSA-N
Pubchem ID :6918427

Safety of Aliskiren hemifumarate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6J mice Diet-induced obesity model Subcutaneous osmotic pump 50 mg/kg Once daily for 6 weeks Aliskiren reduced body-weight gain, adipose pads and plasma leptin concentration, independent of the diet. In adipose tissue, local concentrations of Ang II were also reduced by aliskiren. Br J Pharmacol. 2009 Oct;158(3):771-8

Protocol

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1 mM

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0.82mL

0.16mL

0.08mL

4.10mL

0.82mL

0.41mL

8.20mL

1.64mL

0.82mL

References

 

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