CAS No. :	892711-75-0
Formula :	C₂₀H₂₀N₂O₂
M.W :	320.39
SMILES Code :	O=C(NC1=C2N=C(C)C=CC2=CC=C1)C3=CC=C(OC(C)C)C=C3
MDL No. :	MFCD07177494
InChI Key :	GVGVYDCVFBGALZ-UHFFFAOYSA-N
Pubchem ID :	16016585

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Mouse renal tubular epithelial cells (mRTECs)	10 µM	1 hour pretreatment followed by 24 hours treatment	CDN1163 restored Cd2+-induced reduction in ER Ca2+ content and decreased the expression of ER stress markers BiP, PDI, and apoptosis marker cleaved caspase-3	Int J Mol Sci. 2023 Mar 22;24(6):5979.
HT22 cells	10 µM	10 min	CDN1163 enhanced cytoplasmic Ca2+ clearance of SERCA2 mutants and attenuated hypo-glutamate-induced excitotoxicity	Front Pharmacol. 2022 Apr 20;13:877175.
Reconstituted proteoliposomes (containing SERCA1a isoform)	10 µM	15 minutes	Confirmed direct interaction with SERCA protein showing ~26% increase in charge displacement	ChemMedChem. 2021 Nov 5;16(21):3293-3299.
Rabbit skeletal muscle SR vesicles	10 µM	15 minutes	CDN1163 significantly enhanced ATP-dependent Ca2+ translocation by SERCA with ~30% increase in charge displacement	ChemMedChem. 2021 Nov 5;16(21):3293-3299.
Jurkat T lymphocytes	10 µM	20 min	Short-term exposure to CDN1163 significantly increased Ca2+ release responses induced by low-dose tBHQ, indicating enhanced Ca2+ release from the SERCA 3-regulated Ca2+ pool.	Int J Mol Sci. 2024 Nov 11;25(22):12095.
HT22 mouse hippocampal neurons	1 µM	24 hours	CDN1163 significantly alleviated heat stress-induced calcium imbalance, reduced cytoplasmic Ca2+ levels and elevated ER Ca2+ levels, inhibited p-PERK and p-eIF2α protein expression, effectively attenuating endoplasmic reticulum stress and apoptosis.	Cell Death Discov. 2024 Jun 11;10(1):280.
H1395 cells	10 µM	24 hours	CDN1163 attenuated mitochondrial dysfunction in IAV-infected H1395 cells.	J Virol. 2021 Apr 26;95(10):e00217-21.
H9c2 cells	10 µM	24 hours	CDN1163 markedly abolished glucose-stimulated NFATc nuclear translocation, reduced resistin and nuclear NFATc expression, and increased AMPKα phosphorylation.	Sci Rep. 2018 Oct 23;8(1):15633.
HEK cells	10 µM	2-hours pretreatment followed by 16-hours exposure to H2O2	To evaluate the rescue effect of CDN1163 on ER stress-induced cell death; CDN1163 significantly attenuated H2O2-stimulated cell death	J Biol Chem. 2016 Mar 4;291(10):5185-98.
Jurkat T lymphocytes	25 µM	30 min	Short-term exposure to CDN1163 significantly inhibited Ca2+ uptake, suggesting SERCA function was suppressed.	Int J Mol Sci. 2024 Nov 11;25(22):12095.
H2K-mdx myotubes	100 µM	30 minutes	CDN1163 significantly reduced cytosolic Ca2+ levels in H2K-mdx myotubes	Hum Mol Genet. 2021 May 31;30(11):1006-1019.
Lymphatic muscle cells (LMCs)	5 µM	48 hours	To evaluate the effect of CDN1163 on SERCA activity in insulin-resistant LMCs. Results showed that CDN1163 partially restored the contractile frequency of lymphatic vessels.	Sci Rep. 2020 Jul 23;10(1):12320.
Jurkat T lymphocytes	10 µM	72 hours	Long-term exposure to CDN1163 increased Ca2+ store levels in the SERCA 2b pool but decreased store levels in the SERCA 3-regulated pool.	Int J Mol Sci. 2024 Nov 11;25(22):12095.

Mice	Diabetic Mice model (db/db mice)	Intraperitoneal injection	100 mg/kg	5 consecutive days	CDN1163 improved glucose tolerance, hepatosteatosis, skeletal muscle function, and insulin resistance in db/db mice.	Cells. 2022 Apr 28;11(9):1488
C57BL/6 mice	Heat stress-induced cognitive impairment model	Intraperitoneal injection	20 mg/kg	Once daily for 7 days	CDN1163 upregulated SERCA expression, restored Ca2+ homeostasis, improved learning and memory abilities, and alleviated hippocampal neuronal damage and endoplasmic reticulum stress-mediated apoptosis.	Cell Death Discov. 2024 Jun 11;10(1):280.
Mdx mice	Duchenne muscular dystrophy model	Intraperitoneal injection	40 mg/kg	Three times per week for 7 weeks	CDN1163 ameliorated dystrophic phenotypes in mdx mice, including reduced muscle degeneration and fibrosis, enhanced muscle strength, and restored mitochondrial function	Hum Mol Genet. 2021 May 31;30(11):1006-1019.
Ob/ob mice (obese/diabetic model)	Insulin resistance and type 2 diabetes model	Intraperitoneal injection	50 mg/kg	Once daily for 5 consecutive days	To evaluate the effects of CDN1163 on blood glucose and metabolic parameters; CDN1163 significantly reduced fasting blood glucose, improved glucose tolerance, ameliorated hepatic steatosis, increased energy expenditure, and upregulated UCP1 and UCP3 expression in brown adipose tissue. Effects persisted for >6 weeks post-treatment.	J Biol Chem. 2016 Mar 4;291(10):5185-98.
Ob/ob mice	Diabetic mice model	Intraperitoneal injection	50 mg/kg	3× /week for 30 days	CDN1163 treatment significantly decreased resistin and nuclear NFATc protein expression and increased AMPKα activity/phosphorylation.	Sci Rep. 2018 Oct 23;8(1):15633.
Mice	CuZnSOD deficient Mice model	Intraperitoneal injection	50 mg/kg	Three times per week for 7 weeks	CDN1163 completely restored SERCA activity and reversed the 23% reduction in gastrocnemius mass and 22% reduction in specific force in untreated Sod1-/- versus wild type mice. These changes were accompanied by restoration of autophagy protein markers to the levels found in wild-type mice. CDN1163 also reversed the increase in mitochondrial ROS generation and oxidative damage in muscle tissue from Sod1-/- mice.	Redox Biol. 2019 Jan;20:68-74
Mice	Wild-type (WT) and melanocortin-4 receptor knockout (Mc4r−/−) mice	Injections	50 mg/kg	Once every 2 weeks for 8 weeks (four total doses); or three times per week for 8 weeks (24 total doses)	Studied the effects of CDN1163 on diet-induced steatohepatitis, showing that CDN1163 improved liver fibrosis and inflammation, restored glucose tolerance and insulin sensitivity, increased antioxidant enzyme expression, and decreased oxidative stress and ER stress gene expression.	J Lipid Res. 2024 Jun;65(6):100558
Wistar rats	Hindlimb unloading/suspension model	Intraperitoneal injection	50 mg/kg	Once daily for 7 days	Treatment with SERCA activator CDN1163 during 7 days of unloading prevented an increase in soleus fatigue, the decrease of slow-type myosin, mitochondrial markers, and markers of calcium homeostasis but had no effect on muscle atrophy.	Biomolecules. 2023 Sep 6;13(9):1354
C57BL/6J mice	Aged mice	Intra-peritoneal injection	50 mg/kg	Three times per week for 10 months	CDN1163 treatment via diet and injection prevented age-related muscle atrophy and weakness, restored SERCA ATPase activity, and improved mitochondrial function.	Int J Mol Sci. 2020 Dec 22;22(1):37

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	3.12mL 0.62mL 0.31mL	15.61mL 3.12mL 1.56mL	31.21mL 6.24mL 3.12mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

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CAS No.: 892711-75-0

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CAS No.: 892711-75-0

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed