CAS No. :	1570496-34-2
Formula :	C₂₅H₂₅F₃N₆O₄S
M.W :	562.56
SMILES Code :	FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O)(C)=O)CC5)=C4)C(C)=N3)=N2)C=C1
Synonyms :	IACS-10759
MDL No. :	MFCD30489429
InChI Key :	HWJWNWZJUYCGKV-UHFFFAOYSA-N
Pubchem ID :	86711931

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

KELLY cells	10 mM and 100 mM	24 hours	IACS-010759 significantly suppressed the oxygen consumption rate (OCR) in KELLY cells, indicating its inhibition of OXPHOS.	Cancer Res. 2021 Sep 1;81(17):4417-4430.
H1299 cells	100 nM	24-48 hours	To evaluate the growth inhibitory effect of IACS-010759 on SMARCA4 deficient cells, results showed that SMARCA4 reconstitution significantly restored cell viability.	Nat Med. 2018 Jul;24(7):1047-1057.
A549 cells	100 nM	24-48 hours	To evaluate the growth inhibitory effect of IACS-010759 on SMARCA4 deficient cells, results showed that SMARCA4 reconstitution significantly restored cell viability.	Nat Med. 2018 Jul;24(7):1047-1057.
H2030 cells	100 nM	24-48 hours	To evaluate the growth inhibitory effect of IACS-010759 on SMARCA4 deficient cells, results showed that SMARCA4 reconstitution significantly restored cell viability.	Nat Med. 2018 Jul;24(7):1047-1057.
FL5.12 cells, MYC-overexpressing B-cell lines	135 nM	48 hours	The purpose of this experiment was to assess the cytotoxic effect of IACS-010759 in MYC-overexpressing cells. The results indicated that ascorbate potentiated the pro-oxidant and antitumoral effects of IACS-010759.	EMBO Mol Med. 2023 Jun 7;15(6):e16910.
SK-N-BE(2) cells	10 mM and 100 mM	5 days	IACS-010759 significantly suppressed the growth of SK-N-BE(2) cells and induced apoptosis.	Cancer Res. 2021 Sep 1;81(17):4417-4430.
SK-N-DZ cells	10 mM and 100 mM	5 days	IACS-010759 significantly suppressed the growth of SK-N-DZ cells and induced apoptosis.	Cancer Res. 2021 Sep 1;81(17):4417-4430.
SK-N-FI cells	10 mM and 100 mM	5 days	IACS-010759 significantly suppressed the growth of SK-N-FI cells and induced apoptosis.	Cancer Res. 2021 Sep 1;81(17):4417-4430.
SK-N-SH cells	10 mM and 100 mM	5 days	IACS-010759 had a weaker inhibitory effect on the growth of SK-N-SH cells and did not significantly induce apoptosis.	Cancer Res. 2021 Sep 1;81(17):4417-4430.
THP-1 cells	5 µM	72 hours	Inhibition of complex I with IACS-010759 resulted in markedly decreased growth for cells expressing IDH1 R132H, but not for those expressing IDH2 R140Q.	Nat Commun. 2022 May 12;13(1):2614.
MCF7 LTED cells	4.7 nM	72 hours	To evaluate the sensitivity of endocrine therapy and CDK4/6 inhibitor-resistant cells to IACS-010759, results showed that MCF7 LTED cells were more sensitive to IACS-010759.	Nat Commun. 2023 Jul 14;14(1):4221.
MCF7 PalboR cells	0.6 nM	72 hours	To evaluate the sensitivity of endocrine therapy and CDK4/6 inhibitor-resistant cells to IACS-010759, results showed that MCF7 PalboR cells were more sensitive to IACS-010759.	Nat Commun. 2023 Jul 14;14(1):4221.
H460 cells	0.63, 1.25, 2.5, 5.0, 10, and 20 mM	72 hours	To evaluate the synergistic effect of IACS-010759 with trametinib, the results showed that the combination produced a strong synergy (CI <0.7) in H460 cells.	Acta Pharm Sin B. 2023 Mar;13(3):1145-1163.
Calu-1 cells	0.63, 1.25, 2.5, 5.0, 10, and 20 mM	72 hours	To evaluate the synergistic effect of IACS-010759 with trametinib, the results showed that the combination produced a strong synergy (CI <0.7) in Calu-1 cells.	Acta Pharm Sin B. 2023 Mar;13(3):1145-1163.
H441 cells	0.63, 1.25, 2.5, 5.0, 10, and 20 mM	72 hours	To evaluate the synergistic effect of IACS-010759 with trametinib, the results showed that the combination produced a strong synergy (CI <0.7) in H441 cells.	Acta Pharm Sin B. 2023 Mar;13(3):1145-1163.
T-ALL cells	0-123 nM	96 hours	IACS-010759 causes potent growth inhibition through induction of metabolic shut-down and redox imbalance in NOTCH1-mutated T-ALL cells.	Nat Commun. 2022 May 19;13(1):2801.
Glioma cell lines	5 μmol/L	8-14 days	To evaluate the long-term effects of Gamitrinib on glioma cell proliferation. Results showed that Gamitrinib significantly inhibited proliferation in all glioma cell lines.	Clin Cancer Res. 2022 May 13;28(10):2180-2195.

CD1 nude mice and NSG mice	Lymphoma xenografts	Oral Gavage and Intraperitoneal injection	1 or 2.5 mg/kg	Daily doses until tumor progression was measured	The purpose was to determine the in vivo antitumor efficacy of IACS-010759 in combination with ascorbate. The results showed significant tumor regression in the double-treated groups.	EMBO Mol Med. 2023 Jun 7;15(6):e16910.
Mice	ER+ breast cancer PDX models	Oral	10 mg/kg	5 days per week for 50 days	To evaluate the anti-tumour activity of IACS-010759 in ER+ breast cancer PDX models, results showed that IACS-010759 significantly inhibited tumour growth.	Nat Commun. 2023 Jul 14;14(1):4221.
Zebrafish	MYCN-driven neuroblastoma model		100 nmol/L	96 hours	IACS-010759 significantly suppressed the growth of MYCN-driven neuroblastoma in zebrafish models.	Cancer Res. 2021 Sep 1;81(17):4417-4430.
Mice	Notch1-mutated T-ALL model	Oral	5 mg/kg	5 days per week for 5 weeks	IACS-010759 significantly delayed leukemia progression and extended survival in a Notch1-mutated T-ALL mouse model.	Nat Commun. 2022 May 19;13(1):2801.
C57BL/6 and BALB/cA Nude mice	H460 xenograft model	Oral	5 mg/kg	Once daily for 21 days	To evaluate the inhibitory effect of IACS-010759 combined with trametinib on H460 xenograft tumors, the results showed that the combination significantly inhibited tumor growth and prolonged mouse survival.	Acta Pharm Sin B. 2023 Mar;13(3):1145-1163.
Mice	Intracranial melanoma xenograft model	Oral	5 mg/kg	Once daily for 42 days	IACS-010759 significantly improved survival in mice bearing intracranial melanoma xenografts and inhibited brain metastasis formation in the spontaneous brain metastasis model.	Cancer Discov. 2019 May;9(5):628-645
Mice	OC-PDX models	Oral	7.5 mg/kg	5 days on/2 off	To evaluate the therapeutic effects of IACS-010759 on tumor progression.	Cancer Res. 2022 Apr 1;82(7):1423-1434
Mice	KPS tumor model	Oral	7.5mg/kg	Once daily for a total of three weeks	To evaluate the in vivo anti-tumor efficacy of IACS-010759 on KPS tumors, results showed that IACS-010759 significantly inhibited the growth of KPS tumors.	Nat Med. 2018 Jul;24(7):1047-1057.
129Sv/Ev mice	PD-1 resistant and PD-1 sensitive 344SQ NSCLC adenocarcinoma xenograft models	Oral	7.5 mg/kg	Once daily until the endpoint	To evaluate the antitumor effect of IACS-010759 in combination with radiotherapy, results showed that in the PD-1 resistant model, IACS-010759 significantly inhibited tumor growth and combined therapy increased local control	J Immunother Cancer. 2020 Jun;8(1):e000289.

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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CAS No.: 1570496-34-2

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CAS No.: 1570496-34-2

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed