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Chemical Structure| 621-59-0 Chemical Structure| 621-59-0

Structure of Isovanillin
CAS No.: 621-59-0

Chemical Structure| 621-59-0

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Isovanicaline, a natural product isolated and purified from the barks of Pinus yunnanensis, is a selective inhibitor of aldehyde oxidase, is metabolized by aldehyde dehydrogenase into isovanillic acid ,and the LD50 (rat, ipr) is 1276 mg/kg.

Synonyms: 3-Hydroxy-4-methoxybenzaldehyde; 5-Formylguaiacol; 3-Hydroxy-p-anisaldehyde

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Elsheikh, Ahmed ; Bist, Ganesh ; Kim, Sewon ; Huang, Ruea-Yea ; Ruszaj, Donna ; Angevine, Devin , et al.

Abstract: The (APJ) has emerged as a potential novel therapeutic target in cancer due to its role in regulating cell proliferation, , and metastasis. However, , the only known selective small molecule APJ antagonist, exhibits poor plasma and liver microsomal stability, limiting its in vivo applicability. To overcome these limitations, a focused medicinal chemistry effort was undertaken to design and synthesize a second-generation series of APJ antagonists with improved metabolic stability while retaining APJ antagonist activity. Structure–activity relationship analysis identified compound 12 (YL-GB063) as the most favorable analog, displaying enhanced liver microsomal stability relative to lead compounds 6 (YL-GB053) and 7 (YL-GB054), while maintaining APJ inhibition. Pharmacokinetic evaluation revealed a >25-fold increase in systemic exposure compared to . In an orthotopic ovarian cancer xenograft mouse model, YL-GB063 significantly increased median survival and reduced metastatic tumor burden and ascites formation compared to both control and ML221-treated groups.

Purchased from AmBeed: ; ;

Sitter, James D ; Richardson, Tyler J ; Jones, Zachariah JK ; Dysart, Jennifer L ; Laskoski, Matthew ;

Abstract: High temperature resins are of interest in many applications including use in extreme environments including atmospheric reentry. Finding methodology to reduce additives while increasing processability for these resins while simultaneously relying less on petroleum-based products is of high importance so that large-scale manufacturing becomes more accessible. Herein, we report the synthesis of a series of new vanillin-oxydianiline (Vn-ODA) based phthalonitrile (PN) resins. These resins contain the bio-based monomer, , along with internal initiators via an imine linkage formed by the and ODA molecules, eliminating the requirement for additives to initiate curing. The resulting resins exhibit good thermo-oxidative properties with char yields under N2 above 75% and thermolytic degradation above 490°C under air. Furthermore, the meta- and para- resins exhibit promising processing windows with low melt temperatures and a Tg above final cure temperature.

Keywords: bio-based ; high-char ; initiator ; internal ; thermo-oxidative

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Alternative Products

Product Details of Isovanillin

CAS No. :621-59-0
Formula : C8H8O3
M.W : 152.15
SMILES Code : O=CC1=CC=C(OC)C(O)=C1
Synonyms :
3-Hydroxy-4-methoxybenzaldehyde; 5-Formylguaiacol; 3-Hydroxy-p-anisaldehyde
English Name :3-Hydroxy-4-Methoxybenzaldehyde
MDL No. :MFCD00003369
InChI Key :JVTZFYYHCGSXJV-UHFFFAOYSA-N
Pubchem ID :12127

Safety of Isovanillin

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.57mL

1.31mL

0.66mL

32.86mL

6.57mL

3.29mL

65.72mL

13.14mL

6.57mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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