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Chemical Structure| 176161-24-3 Chemical Structure| 176161-24-3

Structure of Maribavir
CAS No.: 176161-24-3

Chemical Structure| 176161-24-3

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Maribavir proves to be a potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro, displaying an IC50 of 3 nM. It exhibits potent antiviral activity against HCMV and Epstein-Barr virus (EBV).

Synonyms: GW257406X; 1263W94; VP-41263

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Product Details of Maribavir

CAS No. :176161-24-3
Formula : C15H19Cl2N3O4
M.W : 376.24
SMILES Code : CC(C)NC1=NC2=C(C=C(Cl)C(Cl)=C2)N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O
Synonyms :
GW257406X; 1263W94; VP-41263
MDL No. :MFCD00945570

Safety of Maribavir

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Akata cells 20 μM 24 hours MBV almost completely inhibited the appearance of the 54-kDa and 52-kDa EA-D products and also reduced the level of 49-kDa EA-D PMC2786727
Akata cells 20 μM 24 hours MBV inhibits phosphorylation of EBV early antigen EA-D PMC2786727
293 cells 20 μM 48 hours MBV inhibits EBV transcription and replication by inhibiting BGLF4 protein kinase activity PMC3624302
Human foreskin fibroblasts (HFF) 10 µM 5 to 6 days To evaluate the effect of MBV on GCV antiviral activity, results showed MBV increased GCV EC50 by 13-fold PMC1610080
Human embryonic lung (HEL) fibroblasts 0.32 µM 5 to 6 days To evaluate the effect of MBV on GCV antiviral activity, results showed MBV increased GCV EC50 by ninefold PMC1610080
Human foreskin fibroblast (HFF) 0.5-25 μM 5-20 passages Selection of UL97 and UL27 mutations, discovery of new UL97 mutation L337M and UL27 mutations D534Y, R448P PMC3398170
ARPEp cells 48.0 μM 6 days Evaluate the inhibitory effect of Maribavir on L397R mutant CMV, EC50 was 48.0 μM PMC10922325
ARPEp cells 0.118 μM 6 days Evaluate the inhibitory effect of Maribavir on wild-type CMV, EC50 was 0.118 μM PMC10922325
MRC-5 fibroblasts 40 μM 72 hours Evaluate the inhibitory effect of MBV on hCMV DNA synthesis, results showed MBV alone reduced viral DNA levels by an average of 95% PMC3845884
U373 cells 40 μM 72 hours Evaluate the inhibitory effect of MBV on hCMV DNA synthesis, results showed MBV alone reduced viral DNA levels by an average of 40% PMC3845884
Human embryonic lung fibroblasts 0.1-10 μM weekly passage To evaluate the antiviral activity of Maribavir against CMV and the emergence of resistance mutations PMC2612169

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00002373 Cytomegalovirus Infections|HIV... More >> Infections Less << PHASE1 COMPLETED - Univ of California/ San Franci... More >>sco / Dept of Medicine, San Francisco, California, 94110, United States|Dr Jacob Lalezari, San Francisco, California, 94115, United States Less <<
NCT00411645 Cytomegalovirus Infections Phase 3 Completed - -
NCT00497796 Cytomegalovirus Infections Phase 3 Completed - -
NCT00411645 - Completed - -
NCT02927067 Cytomegalovirus (CMV) Phase 3 Recruiting August 13, 2021 -
NCT00223925 Cytomegalovirus Infection Phase 2 Completed - United States, California ... More >> City of Hope Medical Center Duarte, California, United States UCLA Medical Center Los Angeles, California, United States United States, Illinois Loyola University Maywood, Illinois, United States United States, Massachusetts Tufts-New England Medical Center Boston, Massachusetts, United States United States, Michigan Wayne State Medical Center Detroit, Michigan, United States United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States United States, Missouri Washington University School of Medicine St. Louis, Missouri, United States United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States United States, North Carolina Duke Medical Center Durham, North Carolina, United States United States, Texas Baylor University Medical Center Dallas, Texas, United States MD Anderson Cancer Center Houston, Texas, United States United States, Utah University of Utah Salt Lake City, Utah, United States United States, Washington Fred Hutchinson Cancer Research Center Seattle, Washington, United States Less <<
NCT00497796 - Completed - -
NCT02931539 Cytomegalovirus (CMV) Phase 3 Recruiting May 6, 2019 -
NCT01611974 Cytomegalovirus (CMV) PHASE2 COMPLETED 2014-12-05 UCLA Medical Center, Los Angel... More >>es, California, 90095, United States|Stanford University Medical Center, Stanford, California, 94305, United States|University of Colorado, Denver, Colorado, 80045, United States|Yale University, New Haven, Connecticut, 06520, United States|University of Florida, Gainesville, Florida, 32610, United States|Tampa General Hospital, Tampa, Florida, 33614, United States|Emory University, Atlanta, Georgia, 30322, United States|Northwestern University Medical Center, Chicago, Illinois, 60611, United States|University of Chicago, Chicago, Illinois, 60637, United States|Ochsner Clinic Foundation, New Orleans, Louisiana, 70121, United States|Johns Hopkins Hospital, Baltimore, Maryland, 21205, United States|Brigham and Women's Hospital, Boston, Massachusetts, 02115, United States|University of Massachusetts, Worcester, Massachusetts, 01655, United States|University of Michigan, Ann Arbor, Michigan, 48109, United States|Henry Ford Health Care System, Detroit, Michigan, 48202, United States|University of Minnesota Medical Center, Minneapolis, Minnesota, 55454, United States|University of Nebraska, Omaha, Nebraska, 68198, United States|Columbia University, New York, New York, 10032, United States|Memorial Sloan-Kettering Cancer Center, New York, New York, 10065, United States|Duke University Medical Center, Durham, North Carolina, 30322, United States|Wake Forest Medical Center, Winston-Salem, North Carolina, 27157, United States|Cleveland Clinic Foundation, Cleveland, Ohio, 44195, United States|Nationwide Children's Hospital, Columbus, Ohio, 43205, United States|University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|Albert Einstein Medical Center, Philadelphia, Pennsylvania, 19141, United States|University of Pittsburg, Pittsburgh, Pennsylvania, 15213, United States|Medical University of South Carolina, Charleston, South Carolina, 29425, United States|Vanderbilt Medical Center, Nashville, Tennessee, 37212, United States|Methodist Healthcare System, San Antonio, Texas, 78229, United States|University of Utah, Salt Lake City, Utah, 84132, United States|University of Washington, Seattle, Washington, 98109, United States|Fred Hutchinson Cancer Research Center, Seattle, Washington, 98195, United States Less <<
NCT02775240 Cytomegalovirus (CMV) Phase 1 Completed - United States, Florida ... More >> Clinical Pharmacology of Miami, Inc. Miami, Florida, United States, 33014 Less <<
NCT01611974 Cytomegalovirus (CMV) PHASE2 COMPLETED 2014-12-05 UCLA Medical Center, Los Angel... More >>es, California, 90095, United States|Stanford University Medical Center, Stanford, California, 94305, United States|University of Colorado, Denver, Colorado, 80045, United States|Yale University, New Haven, Connecticut, 06520, United States|University of Florida, Gainesville, Florida, 32610, United States|Tampa General Hospital, Tampa, Florida, 33614, United States|Emory University, Atlanta, Georgia, 30322, United States|Northwestern University Medical Center, Chicago, Illinois, 60611, United States|University of Chicago, Chicago, Illinois, 60637, United States|Ochsner Clinic Foundation, New Orleans, Louisiana, 70121, United States|Johns Hopkins Hospital, Baltimore, Maryland, 21205, United States|Brigham and Women's Hospital, Boston, Massachusetts, 02115, United States|University of Massachusetts, Worcester, Massachusetts, 01655, United States|University of Michigan, Ann Arbor, Michigan, 48109, United States|Henry Ford Health Care System, Detroit, Michigan, 48202, United States|University of Minnesota Medical Center, Minneapolis, Minnesota, 55454, United States|University of Nebraska, Omaha, Nebraska, 68198, United States|Columbia University, New York, New York, 10032, United States|Memorial Sloan-Kettering Cancer Center, New York, New York, 10065, United States|Duke University Medical Center, Durham, North Carolina, 30322, United States|Wake Forest Medical Center, Winston-Salem, North Carolina, 27157, United States|Cleveland Clinic Foundation, Cleveland, Ohio, 44195, United States|Nationwide Children's Hospital, Columbus, Ohio, 43205, United States|University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|Albert Einstein Medical Center, Philadelphia, Pennsylvania, 19141, United States|University of Pittsburg, Pittsburgh, Pennsylvania, 15213, United States|Medical University of South Carolina, Charleston, South Carolina, 29425, United States|Vanderbilt Medical Center, Nashville, Tennessee, 37212, United States|Methodist Healthcare System, San Antonio, Texas, 78229, United States|University of Utah, Salt Lake City, Utah, 84132, United States|University of Washington, Seattle, Washington, 98109, United States|Fred Hutchinson Cancer Research Center, Seattle, Washington, 98195, United States Less <<
NCT05137717 Cytomegalovirus (CMV) PHASE3 COMPLETED 2023-06-27 Ehime University Hospital, Too... More >>n, Ehime, Japan|Kyushu University Hospital, Fukuoka-shi, Fukuoka, Japan|Sapporo Hokuyu Hospital, Sapporo-Shi, Hokkaido, Japan|Hokkaido University Hospital, Sapporo, Hokkaido, Japan|Sapporo City General Hospital, Sapporo, Hokkaido, Japan|University of Tsukuba Hospital, Tsukuba-shi, Ibaraki, Japan|Imamura General Hospital, Kagoshima-shi, Kagoshima, Japan|Osaka International Cancer Institute, Osaka-shi, Osaka, Japan|Osaka University Hospital, Suita, Osaka, Japan|Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan|The Jikei University Hospital, Minato-ku, Tokyo, Japan|Toranomon Hospital, Minato-ku, Tokyo, Japan|Keio University Hospital, Shinjuku-ku, Tokyo, Japan|Yochomachi Clinic, Shinjuku-ku, Tokyo, Japan|Chiba University Hospital, Chiba, Japan|Fukushima Medical University Hospital, Fukushima, Japan|Kyoto University Hospital, Kyoto, Japan|Okayama University Hospital, Okayama, Japan|Osaka Metropolitan University Hospital, Osaka, Japan|Jichi Medical University Saitama Medical Center, Saitama, Japan Less <<
NCT05319353 Cytomegalovirus (CMV) PHASE3 ACTIVE_NOT_RECRUITING 2027-01-18 University of Nebraska Medical... More >> Center -985400 Nebraska Medical Center, Omaha, Nebraska, 68114-4113, United States|Cincinnati Children's Hospital Medical Center - PIN, Cincinnati, Ohio, 45229-3026, United States|Cook Children's Health Care System, Fort Worth, Texas, 76104-2733, United States|University of Texas MD Anderson Cancer Center - 1515 Holcombe Blvd, Houston, Texas, 77030-4000, United States|Sydney Children's Hospital, Randwick, New South Wales, 2031, Australia|Queensland Children's Hospital, South Brisbane, Queensland, 4101, Australia|Royal Children's Hospital Melbourne - PIN, Parkville, Victoria, 3052, Australia|Perth Children's Hospital, Nedlands, Western Australia, 6009, Australia|H?pital Universitaire des Enfants Reine Fabiola (HUDERF), Bruxelles, Brussels, 1020, Belgium|Cliniques Universitaires Saint-Luc, Sint-Lambrechts-Woluwe, Brussels, 1200, Belgium|UZ Gent, Gent, Oost-Vlaanderen, 9000, Belgium|Irmandade Da Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Rio Grande Do Sul, 90020-090, Brazil|Hospital de Clinicas de Porto Alegre (HCPA) - PPDS, Porto Alegre, Rio Grande Do Sul, 90035-903, Brazil|Hospital das Clínicas da Faculdade de Medicina da Universidade de S?o Paulo, Porto Alegre, Rio Grande Do Sul, 90160-093, Brazil|Hospital Do Rim E Hipertens?o, S?o Paulo, 04038-002, Brazil|Children's Hospital Capital Institute of Pediatrics, Beijing, Beijing, 100020, China|Beijing Children's Hospital, Capital Medical University - PIN, Beijing, Beijing, 100045, China|Shanghai Children's Medical Center, Shanghai, Shanghai, 200127, China|Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences - PPDS, Tianjin, Tianjin, 300020, China|CHU de Rennes - H?pital Pontchaillou, Rennes, Ille-et-Vilaine, 35200, France|CHU de Grenoble Alpes - H?pital Michallon, La Tronche, Isère, 38700, France|CHRU Nantes, Nantes, Loire-Atlantique, 44000, France|Hopital Necker, Paris, 75015, France|Universit?tsklinikum Würzburg, Würzburg, Bayern, 97080, Germany|Universit?tsklinikum Münster, Münster, Nordrhein-Westfalen, 48149, Germany|Universitatsklinikum Jena - Am Klinikum 1-Erlanger Allee 101, Jena, Thüringen, 07745, Germany|Universit?tsklinikum Hamburg Eppendorf, Hamburg, 20246, Germany|Medizinische Hochschule Hannover, Hannover, 30625, Germany|The Chaim Sheba Medical Center - PPDS, Ramat Gan, Tel-Aviv, 52394, Israel|Tel Aviv Sourasky Medical Center Ichilov - PPDS, Tel Aviv-Yafo, Tel-Aviv, 64239, Israel|Rambam Health Care Campus - PPDS, Haifa, 31096, Israel|Hadassah Medical Center- Ein Kerem - PPDS, Petah Tiqva, 4920235, Israel|National Center for Child Health and Development, Nagoya-Shi, Aiti, 453-0046, Japan|Saitama Children's Medical Center, Isehara-Shi, Kanagawa, 259-1143, Japan|Shizuoka Children's Hospital, Aoi-ku, Sizuoka, 420-8660, Japan|Hyogo Prefectural Kobe Children's Hospital, Chiba-Shi, 650-0047, Japan|Osaka Women's and Children's Hospital, Izumi-Shi, ?saka, 594-1101, Japan|Hospital Sant Joan de Deu - PIN, Espluges De Llobregat, Barcelona, 08950, Spain|Hospital Universitario La Paz - PPDS, Horcajo de la Sierra, Madrid, 28755, Spain|Hospital Regional Universitario de Malaga - Hospital Materno-Infantil, Malaga, Málaga, 29011, Spain|Hospital Universitario Vall d′Hebron- PPDS, Barcelona, 08035, Spain|Hospital Infantil Universitario Ni?o Jesus - PIN, Madrid, 28009, Spain|King's College Hospital, London, Lambeth, SE5 9RS, United Kingdom|Royal Manchester Children's Hospital - PIN, Manchester, Lancashire, M13 9WL, United Kingdom|Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, NG5 1PB, United Kingdom|Birmingham Women's and Children's NHS Foundation Trust, Birmingham, West Midlands, B4 6NH, United Kingdom|Great Ormond Street Hospital, London, WC1N 3JH, United Kingdom Less <<
NCT05382104 Healthy Volunteers PHASE1 COMPLETED 2022-07-02 Celerion, Lincoln, Nebraska, 6... More >>8502, United States Less <<
NCT04131556 Healthy Volunteers PHASE1 TERMINATED 2020-01-06 Clinical Pharmacology of Miami... More >>, Llc, Miami, Florida, 33014, United States Less <<
NCT06577363 Cytomegalovirus (CMV) RECRUITING 2031-08-30 Takeda selected site, Tokyo, J... More >>apan Less <<
NCT06439342 Cytomegalovirus (CMV) PHASE3 NOT_YET_RECRUITING 2027-02-05 Peking University People's Hos... More >>pital, Beijing, North China, 100044, China Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.29mL

2.66mL

1.33mL

26.58mL

5.32mL

2.66mL

References

 

Historical Records

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