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Chemical Structure| 1817841-22-7 Chemical Structure| 1817841-22-7

Structure of MeTC7
CAS No.: 1817841-22-7

Chemical Structure| 1817841-22-7

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MeTC7 is a vitamin D receptor (VDR) antagonist with an IC50 value of 2.9 μM, showing good antitumor activity.

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Citations

Product Citations

Sun, Huaiqing ; Cao, Qiuchen ; He, Xiaoxin ; Du, Xinyu ; Jiang, Xueqin ; Wu, Ting , et al.

Abstract: Chronic sleep restriction (SR) impairs the glymphatic clearance of macromolecular toxic metabolites, which is associated with the loss of perivascular polarization of aquaporin-4 (AQP4). (Mel) has been shown to maintain the circadian rhythm of AQP4 polarization. However, the role of AQP4 polarization in Mel's protective efects against SR-induced brain dysfunction remains unclear. In the present study, using a modifed rotating rod SR mouse model, we demonstrated the time-dependent efect of SR on short-term memory defcits and AQP4 mislocalization in the hippocampus. Subsequent experiments characterized the dose-dependent pattern of ameliorating SR-induced impairments of cognitive function and AQP4 polarity. Mel’s treatment enhanced glymphatic transport in SR mice, as revealed by cerebrospinal tracer experiments, and reduced hippocampal amyloid-beta and phosphorylated tau levels. Additionally, signifcantly decreased glial cell activation, pro-infammatory cytokine production, and synaptic protein loss in the hippocampus of SR mice. However, in AQP4 knockout mice, Mel's protective efects against SR-induced pathophysiological alterations described above were largely abolished. Mechanistically, activated the vitamin D receptor and then upregulated expression of DTNA (Dystrobrevin Alpha), a key component of the dystrophin-associated complex, which in turn restored AQP4 polarization during chronic SR conditions. This fnding indicates that AQP4-mediated lymphatic clearance is necessary for to combat chronic SR-induced brain impairment.

Keywords: Aquaporin 4 ; Glymphatic system ; Cognitive impairment ; Sleep restriction ;

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Product Details of MeTC7

CAS No. :1817841-22-7
Formula : C32H48BrN3O4
M.W : 618.65
SMILES Code : O=C(O[C@H](C1)CC[C@@]2(C)C1(C=C3)N(C(N(C)C4=O)=O)N4C53[C@@](CC[C@@H]6[C@@H](CCCC(C)C)C)([H])[C@]6(C)CC[C@]25[H])CBr
English Name :(2S,4aR,4bR,6aR,7R,9aR)-4a,6a,12-Trimethyl-7-((R)-6-methylheptan-2-yl)-11,13-dioxo-2,3,4,4a,4b,5,6,6a,7,8,9,9a,12,13-tetradecahydro-1H,11H-9b,14a-ethenobenzo[c]cyclopenta[h][1,2,4]triazolo[1,2-a]cinnolin-2-yl 2-bromoacetate
MDL No. :MFCD34676879

Safety of MeTC7

Isoform Comparison

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Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.62mL

0.32mL

0.16mL

8.08mL

1.62mL

0.81mL

16.16mL

3.23mL

1.62mL

 

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