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Chemical Structure| 76343-22-1 Chemical Structure| 76343-22-1
Chemical Structure| 76343-22-1

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Product Details of MSPC

CAS No. :76343-22-1
Formula : C40H80NO8P
M.W : 734.04
SMILES Code : CCCCCCCCCCCCCCCCCC(O[C@H](COC(CCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O
English Name :(R)-2-(Stearoyloxy)-3-(tetradecanoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
MDL No. :MFCD00674323

Safety of MSPC

Application In Synthesis of MSPC

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 76343-22-1 ]

[ 76343-22-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 76343-22-1 ]
  • [ 108-24-7 ]
  • [ 79549-26-1 ]
YieldReaction ConditionsOperation in experiment
58% With dmap In dichloromethane at 20℃; for 30h; Inert atmosphere; 1 A compound of the above-identified type 1n,R having n=0, and R=C17H35, i.e. 1(n=0, R=C17H35), was prepared as follows. A solution of 4-dimethylaminopyridine (149.1 mg, 1.22 mmol) in dichloromethane (8 mL) dried on molecular sieves was added to 1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine, abbreviated as MSPC (211.8 mg, 0.404 mmol). Subsequently, acetic anhydride (115 µL, 1.23 mmol) was added and the mixture was stirred for 30 hours at room temperature under nitrogen atmosphere to yield a colorless solution. Methanol (8 mL) was added and the solvent was removed at room temperature under reduced pressure. The crude mixture was dissolved in chloroform (8 mL) and the organic layer was extracted three times with a solution of MeOH (8 mL) and 0.1 M HCl (8 mL). The mixture was centrifuged (30 minutes, 4000 rpm) to induce fast phase separation. The remaining organic layer was filtered, and then concentrated on a rotary evaporator at room temperature under reduced pressure. The crude product was dissolved in acetone (30 mL) and the solution was cooled to -20 °C to induce precipitation. To obtain the solid the mixture was centrifuged (30 minutes, 4000 rpm, -19 °C) and the solvent was decanted. The obtained product was washed with acetone, centrifuged (30 minutes, 4000 rpm, -19 °C) and dried with the aid of a nitrogen stream to obtain 1(n=0, R=C17H35 (0.132 g) 58% Yield. The product was analyzed using1H- and 13C NMR spectroscopy
 

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