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Chemical Structure| 610318-03-1 Chemical Structure| 610318-03-1

Structure of RGX-104 HCl
CAS No.: 610318-03-1

Chemical Structure| 610318-03-1

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RGX-104 is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

Synonyms: Abequolixron hydrochloride; Abequolixron; RGX-104

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Product Details of RGX-104 HCl

CAS No. :610318-03-1
Formula : C34H34Cl2F3NO3
M.W : 632.54
SMILES Code : O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4=CC=CC=C4)C)=C1.[H]Cl
Synonyms :
Abequolixron hydrochloride; Abequolixron; RGX-104
MDL No. :MFCD31657403
InChI Key :LCMIYQOJZLRHTO-GJFSDDNBSA-N
Pubchem ID :68861574

Safety of RGX-104 HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02922764 Malignant Neoplasms Phase 1 Recruiting October 2019 United States, California ... More >> Cedars-Sinai Medical Center Recruiting Los Angeles, California, United States, 90048 Contact: Monica Mita, MD    310-248-6729    Monica.Mita@cshs.org    University of California, Los Angeles Recruiting Los Angeles, California, United States, 90095 Contact: Bartosz Chmielowski, MD, PhD    310-586-2650    BChmielowski@mednet.ucla.edu    United States, Colorado Sarah Cannon Research Institute Recruiting Denver, Colorado, United States, 80218 Contact: Gerald Falchook, MD    281-221-0693    gerald.falchook@scresearch.net    United States, New Mexico University of New Mexico Comprehensive Cancer Center Recruiting Albuquerque, New Mexico, United States, 87106 Contact: Olivier Rixe, MD    505-272-4946       United States, New York Columbia University Medical Center Recruiting New York, New York, United States, 10032 Contact: Emerson Lim, MD    202-305-5874    el2342@cumc.columbia.edu    Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Michael Postow, MD    646-888-4589    postowm@mskcc.org    United States, Tennessee The Sarah Cannon Research Institute Recruiting Nashville, Tennessee, United States, 37203 Contact: Erika Hamilton, MD    615-329-7274    ehamilton@tnonc.com    United States, Texas Mary Crowley Cancer Research - Medical City Recruiting Dallas, Texas, United States, 75230 Contact: James F Strauss, MD    214-739-4175       The University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Shubham Pant, MD    713-563-0181    SPant@mdanderson.org Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.58mL

0.32mL

0.16mL

7.90mL

1.58mL

0.79mL

15.81mL

3.16mL

1.58mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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