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Chemical Structure| 373608-48-1 Chemical Structure| 373608-48-1
Chemical Structure| 373608-48-1

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Tert-butyl 4-(3-aminopropyl)piperazine-1-carboxylate is a versatile compound used in peptide synthesis, crosslinking, and functional group attachment.

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Product Details of tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate

CAS No. :373608-48-1
Formula : C12H25N3O2
M.W : 243.35
SMILES Code : O=C(N1CCN(CCCN)CC1)OC(C)(C)C
MDL No. :MFCD06808578
Boiling Point : No data available
InChI Key :DQLCYLFCLQPLSY-UHFFFAOYSA-N
Pubchem ID :17750945

Safety of tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H335-H315-H319-H302
Precautionary Statements:P305+P351+P338-P261

Application In Synthesis of tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 373608-48-1 ]

[ 373608-48-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 55589-47-4 ]
  • [ 373608-48-1 ]
  • tert-butyl 4-(3-(((3-methylpyridin-2-yl)methyl)amino)propyl)piperazine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; To a 50 mL RBF was added tert-butyl 4-(3-aminopropyl)piperazine-1-carboxylate (1.105 g, 4.54 mmol), DCE (Volume: 10.32 ml), 3-methylpicolinaldehyde (.5 g, 4.13 mmol) and STAB-H (1.575 g, 7.43 mmol). The reaction was stirred overnight then diluted with DCM and quenched with 2M NaOH. The organic layer was dried with Na2SO4, filtered and concentrated to a yellow oil which was purified via silica gel chromatography (DCM 2 minutes, 10percent B(80:20:3, DCM:MeOH:NH4OH) 5 minutes and 50percent B 9 minutes) to afford tert-butyl 4-(3-(((3-methylpyridin-2-yl)methyl)amino)propyl)piperazine-1-carboxylate (0.88 g, 2.53 mmol, 61 percent yield).1H NMR (400 MHz, CDCl3): delta = 8.37 (d, J= 5.0 Hz, 1H), 7.42 (d, J= 7.3 Hz, 1H), 7.07 (dd, J= 7.6, 4.8 Hz, 1H), 3.88 (s, 2H), 3.43 (t, J= 5.2 Hz, 4H), 2.79 (t, J= 6.8 Hz, 2H), 2.45 (t, J= 7.2 Hz, 2H), 2.39 (t, J= 5.2 Hz, 4H), 2.30 (s, 3H), 1.78 (pent, J= 7.0 Hz, 2H), 1.45 (s, 9H);
 

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