Products Cited in Publications Worldwide Drug-loaded indocyanine green J-aggregates activate metalloimmunotherapy for sustained photothermal therapy of hepatocellular carcinoma

Drug-loaded indocyanine green J-aggregates activate metalloimmunotherapy for sustained photothermal therapy of hepatocellular carcinoma

He, Kaiming; Chen, Desheng; Zhu, Dongzi; Zheng, Wenjie; Lyu, Lei; Zhang, Mingshen; Chen, Zeping; Wang, Xiaowen; Hu, Yongwei; Fu, Binsheng

DOI: PMID:

Abstract

Hepatocellular carcinoma (HCC) poses a significant therapeutic challenge, driving the need for novel treatment strategies. This study investigates the combination of photothermal therapy (PTT) and metalloimmunotherapy for HCC treatment using Co+diABZI@J-dICG nanoparticles. (ICG), an FDA-approved nearinfrared (NIR) dye, is dimerized into J-aggregates to enhance PTT by improving light absorption and photothermal efficiency. The cGAS-STING pathway, a key mediator of innate immunity, is activated by the agonist diABZI, while cobalt ions (Co2+) further enhance immune responses. The Co+diABZI@J-dICG nanoparticles take advantage of ICG’s hepatotropic properties for sustained tumor accumulation and immune activation, resulting in significant tumor growth inhibition and reduced HCC recurrence following hepatectomy.

Keywords

Hepatocellular carcinoma ; Photothermal therapy ; Metalloimmunotherapy ; ; Nanoparticles

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diABZI STING agonist-1

A12500062138299-33-799%

diABZI STING agonist-1

297.0/5mg

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