RAR/RXR (Retinoic Acid Receptor/Retinoid X Receptor) is a member of the nuclear receptor family, consisting of RARα, RARβ, RARγ, and RXRα, RXRβ, RXRγ. These receptors form heterodimers in the nucleus and are widely distributed in various cells and tissues throughout the body. They primarily regulate gene expression by binding to ligands such as retinoic acid and 9-cis-retinoic acid, participating in processes like cell proliferation, differentiation, and apoptosis. They play crucial roles in development, vision, skin health, and immune system regulation. Gene expression and mutations are associated with health issues including cancer, skin diseases, and retinal disorders.