REV-ERB is part of the nuclear receptor family, consisting mainly of REV-ERBα and REV-ERBβ. These proteins are primarily located in the cell nucleus, regulating various physiological processes including circadian rhythm, metabolism, and inflammatory response. By inhibiting the expression of specific genes, REV-ERB is involved in multiple signaling pathways including lipid metabolism, glucose metabolism, and energy balance. They regulate gene transcription activity by directly binding to the promoter regions of target genes. Specific gene expression and functional mutations of REV-ERB are associated with conditions such as cardiovascular diseases, metabolic disorders, and sleep disturbances.