SQLE (Squalene Epoxidase) is a member of the alcohol oxidase family, responsible for catalyzing the conversion of squalene into squalene epoxide, a crucial step in the cholesterol biosynthesis pathway. The enzyme is primarily localized in the endoplasmic reticulum. SQLE activity is essential for maintaining cell membrane integrity and the synthesis of other biomolecules. Gene expression varies across different tissues, and specific mutations may be associated with the development of certain metabolic disorders and cancers.