Sulfide:quinone oxidoreductase (SQOR) is an enzyme involved in the mitochondrial sulfide metabolism pathway, responsible for converting sulfide to thiol compounds. SQOR is mainly located in the mitochondria and is widely present in various cells and tissues, with particularly high expression levels in the heart, liver, and kidneys. The enzyme plays a crucial role in regulating cellular energy metabolism, antioxidant stress, and cell signaling. The activity and expression of SQOR are regulated by various factors, including redox status and energy requirements. The specific expression and mutations of the gene are associated with various diseases, including metabolic disorders, cardiovascular diseases, and neurodegenerative diseases.