The TAM receptor family includes Tyro3, Axl, and Mer, which are single-pass transmembrane tyrosine kinase receptors. They share common structural features: an extracellular region containing two immunoglobulin-like domains and two fibronectin type III domains, as well as an intracellular tyrosine kinase domain. These receptors are primarily located on the cell membrane and regulate processes such as cell survival, proliferation, migration, and immune modulation by binding ligands such as Gas6 and Protein S. The TAM receptors participate in various biological responses through the activation of signaling pathways such as PI3K/Akt and MAPK. They are expressed in multiple cell types and tissues, and the specificity of their gene expression and mutations are associated with diseases such as cancer, autoimmune diseases, and viral infections.